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Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.

Abstract：

:Immunoglobulin A (IgA) is prominently secreted at mucosal surfaces and coats a fraction of the intestinal microbiota. However, the commensal bacteria bound by IgA are poorly characterized and the type of humoral immunity they elicit remains elusive. We used bacterial flow cytometry coupled with 16S rRNA gene sequencing (IgA-Seq) in murine models of immunodeficiency to identify IgA-bound bacteria and elucidate mechanisms of commensal IgA targeting. We found that residence in the small intestine, rather than bacterial identity, dictated induction of specific IgA. Most commensals elicited strong T-independent (TI) responses that originated from the orphan B1b lineage and from B2 cells, but excluded natural antibacterial B1a specificities. Atypical commensals including segmented filamentous bacteria and Mucispirillum evaded TI responses but elicited T-dependent IgA. These data demonstrate exquisite targeting of distinct commensal bacteria by multiple layers of humoral immunity and reveal a specialized function of the B1b lineage in TI mucosal IgA responses.

journal_name

Immunity

journal_title

Immunity

authors

Bunker JJ,Flynn TM,Koval JC,Shaw DG,Meisel M,McDonald BD,Ishizuka IE,Dent AL,Wilson PC,Jabri B,Antonopoulos DA,Bendelac A

doi

10.1016/j.immuni.2015.08.007

subject

Has Abstract

pub_date

2015-09-15 00:00:00

pages

541-53

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(15)00319-2

journal_volume

43

pub_type

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