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Targeting T Cell Co-receptors for Cancer Therapy.

Abstract：

:Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected to broaden the clinical scope of immunotherapy. Herein, we review the clinical development of CTLA-4-, PD-1-, and PD-L1-blocking antibodies across tumor types and briefly discuss areas of active investigation of potential biomarkers.

journal_name

Immunity

journal_title

Immunity

authors

Callahan MK,Postow MA,Wolchok JD

doi

10.1016/j.immuni.2016.04.023

subject

Has Abstract

pub_date

2016-05-17 00:00:00

pages

1069-78

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(16)30152-2

journal_volume

44

pub_type

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