当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor.

Abstract：

:Despite compromised T cell antigen receptor (TCR) signaling, mice in which tyrosine 136 of the adaptor linker for activation of T cells (LAT) was constitutively mutated (Lat(Y136F) mice) accumulate CD4(+) T cells that trigger autoimmunity and inflammation. Here we show that equipping postthymic CD4(+) T cells with LATY136F molecules or rendering them deficient in LAT molecules triggers a lymphoproliferative disorder dependent on prior TCR engagement. Therefore, such disorders required neither faulty thymic T cell maturation nor LATY136F molecules. Unexpectedly, in CD4(+) T cells recently deprived of LAT, the proximal triggering module of the TCR induced a spectrum of protein tyrosine phosphorylation that largely overlapped the one observed in the presence of LAT. The fact that such LAT-independent signals result in lymphoproliferative disorders with excessive cytokine production demonstrates that LAT constitutes a key negative regulator of the triggering module and of the LAT-independent branches of the TCR signaling cassette.

journal_name

Immunity

journal_title

Immunity

authors

Mingueneau M,Roncagalli R,Grégoire C,Kissenpfennig A,Miazek A,Archambaud C,Wang Y,Perrin P,Bertosio E,Sansoni A,Richelme S,Locksley RM,Aguado E,Malissen M,Malissen B

doi

10.1016/j.immuni.2009.05.013

subject

Has Abstract

pub_date

2009-08-21 00:00:00

pages

197-208

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(09)00322-7

journal_volume

31

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Type 2 Interleukin-4 Receptor Signaling in Neutrophils Antagonizes Their Expansion and Migration during Infection and Inflammation.

    abstract：:Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.06.025

    authors： Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O

    更新日期：2016-07-19 00:00:00

  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency.

    abstract：:Tristetraprolin (TTP) is a widely expressed potential transcription factor that contains two unusual CCCH zinc fingers and is encoded by the immediate-early response gene, Zfp-36. Mice made deficient in TTP by gene targeting appeared normal at birth, but soon manifested marked medullary and extramedullary myeloid hype...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80411-2

    authors： Taylor GA,Carballo E,Lee DM,Lai WS,Thompson MJ,Patel DD,Schenkman DI,Gilkeson GS,Broxmeyer HE,Haynes BF,Blackshear PJ

    更新日期：1996-05-01 00:00:00

  • Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses.

    abstract：:Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinoma and found that Treg cells suppressed ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.08.006

    authors： Joshi NS,Akama-Garren EH,Lu Y,Lee DY,Chang GP,Li A,DuPage M,Tammela T,Kerper NR,Farago AF,Robbins R,Crowley DM,Bronson RT,Jacks T

    更新日期：2015-09-15 00:00:00

  • Bacterial infections promote T cell recognition of self-glycolipids.

    abstract：:Recognition of self is essential for repertoire selection, immune regulation, and autoimmunity and may be a consequence of infection. Self-induced recognition may represent the escape mechanism adopted by pathogens but may also incite autoimmune diseases. Here, we show that bacterial infection may promote activation o...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.04.013

    authors： De Libero G,Moran AP,Gober HJ,Rossy E,Shamshiev A,Chelnokova O,Mazorra Z,Vendetti S,Sacchi A,Prendergast MM,Sansano S,Tonevitsky A,Landmann R,Mori L

    更新日期：2005-06-01 00:00:00

  • Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading.

    abstract：:Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80249-6

    authors： Riese RJ,Wolf PR,Brömme D,Natkin LR,Villadangos JA,Ploegh HL,Chapman HA

    更新日期：1996-04-01 00:00:00

  • FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway.

    abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90142-6

    authors： Gulbins E,Bissonnette R,Mahboubi A,Martin S,Nishioka W,Brunner T,Baier G,Baier-Bitterlich G,Byrd C,Lang F

    更新日期：1995-04-01 00:00:00

  • Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

    abstract：:T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.10.014

    authors： Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH

    更新日期：2017-11-21 00:00:00

  • Genome-wide analysis of histone methylation reveals chromatin state-based regulation of gene transcription and function of memory CD8+ T cells.

    abstract：:Memory lymphocytes are characterized by their ability to exhibit a rapid response to the recall antigen, in which differential transcription is important, yet the underlying mechanism is not understood. We report here a genome-wide analysis of histone methylation on two histone H3 lysine residues (H3K4me3 and H3K27me3...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.006

    authors： Araki Y,Wang Z,Zang C,Wood WH 3rd,Schones D,Cui K,Roh TY,Lhotsky B,Wersto RP,Peng W,Becker KG,Zhao K,Weng NP

    更新日期：2009-06-19 00:00:00

  • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

    abstract：:The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establis...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.09.010

    authors： Ohkura N,Hamaguchi M,Morikawa H,Sugimura K,Tanaka A,Ito Y,Osaki M,Tanaka Y,Yamashita R,Nakano N,Huehn J,Fehling HJ,Sparwasser T,Nakai K,Sakaguchi S

    更新日期：2012-11-16 00:00:00

  • Systems Medicine in Chronic Inflammatory Diseases.

    abstract：:Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.03.022

    authors： Schultze JL,SYSCID consortium.,Rosenstiel P

    更新日期：2018-04-17 00:00:00

  • BLC expression in pancreatic islets causes B cell recruitment and lymphotoxin-dependent lymphoid neogenesis.

    abstract：:CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80199-5

    authors： Luther SA,Lopez T,Bai W,Hanahan D,Cyster JG

    更新日期：2000-05-01 00:00:00

  • Antisocial networking in T helper cells.

    abstract：:T helper cell differentiation is controlled by a network of transcription factors. In this issue of Immunity, Yagi et al. (2010) describe the opposing effects of transcription factors Runx3 and GATA3 in the network promoting T helper 1 cell development. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2010.04.006

    authors： Pham D,Kaplan MH

    更新日期：2010-04-23 00:00:00

  • Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.

    abstract：:ZAP-70 and Syk are PTKs required for TCR and BCR function, respectively. Loss of the Syk PTK results in a nonfunctional BCR. We provide evidence here that ZAP-70 and Syk are functionally homologous in antigen receptor signaling by demonstrating that expression of ZAP-70 in Syk- B cells reconstitutes BCR function. Reco...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90029-2

    authors： Kong GH,Bu JY,Kurosaki T,Shaw AS,Chan AC

    更新日期：1995-05-01 00:00:00

  • Cytokine-producing effector B cells regulate type 2 immunity to H. polygyrus.

    abstract：:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We als...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.01.006

    authors： Wojciechowski W,Harris DP,Sprague F,Mousseau B,Makris M,Kusser K,Honjo T,Mohrs K,Mohrs M,Randall T,Lund FE

    更新日期：2009-03-20 00:00:00

  • Plague's partners in crime.

    abstract：:The hallmark of bubonic plague is the presence of grotesquely swollen lymph nodes, called buboes. This frenzied inflammatory response to Yersinia pestis is poorly understood. In this issue of Immunity, St. John et al. (2014) explore the mechanism by which Y. pestis spreads and thus leads to this striking lymphadenopat...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.09.003

    authors： Davis KM,Isberg RR

    更新日期：2014-09-18 00:00:00

  • Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.

    abstract：:Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00210-2

    authors： Sutkowski N,Conrad B,Thorley-Lawson DA,Huber BT

    更新日期：2001-10-01 00:00:00

  • Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65.

    abstract：:During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80130-2

    authors： Jumaa H,Wollscheid B,Mitterer M,Wienands J,Reth M,Nielsen PJ

    更新日期：1999-11-01 00:00:00

  • A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.

    abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.07.014

    authors： Postat J,Olekhnovitch R,Lemaître F,Bousso P

    更新日期：2018-10-16 00:00:00

  • Baseless assumptions: activation of TLR9 by DNA.

    abstract：:The Toll-like receptor 9 (TLR9) is activated by DNA presented in acidified, intracellular compartments. Previous studies suggested that signaling required unmethylated CpG dinucleotides, but in this issue of Immunity, Haas et al. (2008) challenge this view, showing that DNA can activate TLR9 in a sequence-independent ...

    journal_title：Immunity

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.immuni.2008.02.009

    authors： Gangloff M,Gay NJ

    更新日期：2008-03-01 00:00:00

  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.

    abstract：:We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. F...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80645-7

    authors： He YW,Deftos ML,Ojala EW,Bevan MJ

    更新日期：1998-12-01 00:00:00

  • Distinct Early Serological Signatures Track with SARS-CoV-2 Survival.

    abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.07.020

    authors： Atyeo C,Fischinger S,Zohar T,Slein MD,Burke J,Loos C,McCulloch DJ,Newman KL,Wolf C,Yu J,Shuey K,Feldman J,Hauser BM,Caradonna T,Schmidt AG,Suscovich TJ,Linde C,Cai Y,Barouch D,Ryan ET,Charles RC,Lauffenburger D

    更新日期：2020-09-15 00:00:00

  • Extrathymically Generated Regulatory T Cells Establish a Niche for Intestinal Border-Dwelling Bacteria and Affect Physiologic Metabolite Balance.

    abstract：:The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.04.013

    authors： Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

    更新日期：2018-06-19 00:00:00

  • Myelopoiesis Reloaded: Single-Cell Transcriptomics Leads the Way.

    abstract：:Lineage commitment during myelopoiesis has been linked to late-stage progenitors with multi-lineage potential. In a recent issue of Cell, Paul et al. (2015) now suggest a much earlier commitment toward distinct lineages even prior to the common myeloid progenitor state. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2015.12.019

    authors： Schultze JL,Beyer M

    更新日期：2016-01-19 00:00:00

  • The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures.

    abstract：:Numerous analyses of large patient cohorts identified specific patterns of immune activation associated with patient survival. We established these as the immune contexture, encompassing the type, functional orientation, density, and location of adaptive immune cells within distinct tumor regions. Based on the immune ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2013.07.008

    authors： Galon J,Angell HK,Bedognetti D,Marincola FM

    更新日期：2013-07-25 00:00:00

  • Viral Anti-CRISPR Tactics: No Success without Sacrifice.

    abstract：:Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.08.023

    authors： van Gent M,Gack MU

    更新日期：2018-09-18 00:00:00

  • FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2.

    abstract：:Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO-2L) has been shown to exert important functions during various immunological processes. The involvement of the death adaptor proteins FADD/MORT1, TRADD, and RIP and the apoptosis-initiating caspases-8 and -10 in death signali...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80211-3

    authors： Sprick MR,Weigand MA,Rieser E,Rauch CT,Juo P,Blenis J,Krammer PH,Walczak H

    更新日期：2000-06-01 00:00:00

  • Targeting T Cell Co-receptors for Cancer Therapy.

    abstract：:Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected t...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2016.04.023

    authors： Callahan MK,Postow MA,Wolchok JD

    更新日期：2016-05-17 00:00:00

  • GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation.

    abstract：:The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2019.03.022

    authors： Dougan M,Dranoff G,Dougan SK

    更新日期：2019-04-16 00:00:00

  • The Miami Monkey: A Sunny Alternative to the Berlin Patient.

    abstract：:Curing HIV infection has been impossible, with the exception of the "Berlin Patient." Martinez-Navio et al. (2019) in Miami herein present a rare monkey whose virus was controlled for >3 years after a single genetic intervention that led to persistent production of HIV-neutralizing antibodies in vivo. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.02.010

    authors： Liberatore RA,Ho DD

    更新日期：2019-03-19 00:00:00

  • Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.

    abstract：:The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we s...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.01.016

    authors： Roberts NA,White AJ,Jenkinson WE,Turchinovich G,Nakamura K,Withers DR,McConnell FM,Desanti GE,Benezech C,Parnell SM,Cunningham AF,Paolino M,Penninger JM,Simon AK,Nitta T,Ohigashi I,Takahama Y,Caamano JH,Hayday AC,La

    更新日期：2012-03-23 00:00:00