Abstract：
:According to the traditional view, atherosclerosis results from a passive buildup of cholesterol in the artery wall. Yet, burgeoning evidence implicates inflammation and immune effector mechanisms in the pathogenesis of this disease. Both innate and adaptive immunity operate during atherogenesis and link many traditional risk factors to altered arterial functions. Inflammatory pathways have become targets in the quest for novel preventive and therapeutic strategies against cardiovascular disease, a growing contributor to morbidity and mortality worldwide. Here we review current experimental and clinical knowledge of the pathogenesis of atherosclerosis through an immunological lens and how host defense mechanisms essential for survival of the species actually contribute to this chronic disease but also present new opportunities for its mitigation.
journal_name
Immunityjournal_title
Immunityauthors
Libby P,Lichtman AH,Hansson GKdoi
10.1016/j.immuni.2013.06.009subject
Has Abstractpub_date
2013-06-27 00:00:00pages
1092-104issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(13)00252-5journal_volume
38pub_type
杂志文章,评审相关文献
IMMUNITY文献大全abstract：:TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2008.07.003
更新日期：2008-08-15 00:00:00
abstract：:Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell subset that specializes in production of interleukin (IL)-22. This cytokine pl...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2009.06.008
更新日期：2009-07-17 00:00:00
abstract：:Understanding heterogeneity in adaptive immune responses is essential to dissect pathways of memory B and T cell differentiation and to define correlates of protective immunity. Traditionally, immunologists have deconvoluted this heterogeneity with flow cytometry--with combinations of markers to define signatures that...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.02.001
更新日期：2010-02-26 00:00:00
abstract：:The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2007.05.005
更新日期：2007-05-01 00:00:00
abstract：:Antigen presentation and microbial killing are critical arms of host defense that depend upon cargo trafficking into lysosomes. Yet, the molecular regulators of traffic into lysosomes are only partly understood. Here, using a lysosome-dependent immunological screen of a trafficking shRNA library, we identified the Arf...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2011.06.009
更新日期：2011-08-26 00:00:00
abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2016.08.005
更新日期：2016-08-16 00:00:00
abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2017.01.004
更新日期：2017-02-21 00:00:00
abstract：:Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4+ T cells needed for germinal center...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2019.04.011
更新日期：2019-05-21 00:00:00
abstract：:Toll-like receptors (TLRs) sense pathogen-associated molecular patterns to activate the production of inflammatory mediators. TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. We report that transient receptor potential melastatin-like 7 (TRPM7),...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2017.11.026
更新日期：2018-01-16 00:00:00
abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00288-1
更新日期：2002-03-01 00:00:00
abstract：:NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondep...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2004.05.008
更新日期：2004-06-01 00:00:00
abstract：:Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights a...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/s1074-7613(01)00261-8
更新日期：2002-01-01 00:00:00
abstract：:Commensal microbiota confers a goldilocks state of alertness to pathogens, yet restrains deleterious inflammation. In this issue of Immunity, Geuking et al. (2011) demonstrate that a minimal bacterial community of the Schaedler flora establishes a balance between pro- and anti-inflammatory T cells in the gut. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2011.05.008
更新日期：2011-05-27 00:00:00
abstract：:CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained u...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.01.010
更新日期：2010-02-26 00:00:00
abstract：:Specification of the T helper 17 (Th17) cell lineage requires a well-defined set of transcription factors, but how these integrate with posttranscriptional and epigenetic programs to regulate gene expression is poorly understood. Here we found defective Th17 cell cytokine expression in miR-155-deficient CD4+ T cells i...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2014.03.014
更新日期：2014-06-19 00:00:00
abstract：:EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.11.013
更新日期：2020-12-15 00:00:00
abstract：:The tolerogenic microenvironment of the liver is associated with impaired hepatic T cell function. Here, we examined the contribution of liver-resident natural killer (LrNK) cells, a prominent hepatic NK cell compartment, to T cell antiviral responses in the liver. The number of virus-specific T cells increased in LrN...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.12.024
更新日期：2019-02-19 00:00:00
abstract：:Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2012.07.007
更新日期：2012-07-27 00:00:00
abstract：:In the bone marrow, the special microenvironment niches nurture a pool of hematopoietic stem cells (HSCs). Many HSCs reside near the vasculature, but the molecular regulatory mechanism of niches for HSC maintenance remains unclear. Here we showed that the induced deletion of CXCR4, a receptor for CXC chemokine ligand ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2006.10.016
更新日期：2006-12-01 00:00:00
abstract：:Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal anti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.10.005
更新日期：2020-12-15 00:00:00
abstract：:Lymphatic vessels form a critical component in the regulation of human health and disease. While their functional significance is increasingly being recognized, the comprehensive heterogeneity of lymphatics remains uncharacterized. Here, we report the profiling of 33,000 lymphatic endothelial cells (LECs) in human lym...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2019.06.027
更新日期：2019-09-17 00:00:00
abstract：:In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2013.12.003
更新日期：2014-01-16 00:00:00
abstract：:Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2017.12.001
更新日期：2017-12-19 00:00:00
abstract：:Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2015.11.014
更新日期：2015-12-15 00:00:00
abstract：:Regulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that the c-Rel transcription factor controlled development of Treg...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2009.10.006
更新日期：2009-12-18 00:00:00
abstract：:Cognate interactions of naive T cells with antigen-presenting dendritic cells require physical cell-cell contacts leading to signal induction and T cell activation. Using a three-dimensional collagen matrix videomicroscopy model for ovalbumin peptide-specific activation of murine and oxidative mitogenesis of human T c...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)00032-7
更新日期：2000-09-01 00:00:00
abstract：:Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2005.11.003
更新日期：2005-12-01 00:00:00
abstract：:Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks t...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2012.03.004
更新日期：2012-03-23 00:00:00
abstract：:T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechanism for this enhanc...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90161-2
更新日期：1995-07-01 00:00:00
abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80245-9
更新日期：1997-01-01 00:00:00
