Abstract：
:T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has not been defined. Here, we present data demonstrating that CD28 costimulation enhances the in vitro survival of activated T cells. One mechanism for this enhancement is the ability of CD28 costimulation to augment the production of IL-2, which acts as an extrinsic survival factor for T cells. In addition, CD28 costimulation augments the intrinsic ability of T cells to resist apoptosis. Although CD28 signal transduction had no effect on Bcl-2 expression, CD28 costimulation was found to augment the expression of Bcl-XL substantially. Transfection experiments demonstrated that this level of Bcl-XL could prevent T cell death in response to TCR cross-linking, Fas cross-linking, or IL-2 withdrawal. These data suggest that an important role of CD28 costimulation is to augment T cell survival during antigen activation.
journal_name
Immunityjournal_title
Immunityauthors
Boise LH,Minn AJ,Noel PJ,June CH,Accavitti MA,Lindsten T,Thompson CBdoi
10.1016/1074-7613(95)90161-2subject
Has Abstractpub_date
1995-07-01 00:00:00pages
87-98issue
1eissn
1074-7613issn
1097-4180pii
1074-7613(95)90161-2journal_volume
3pub_type
杂志文章相关文献
IMMUNITY文献大全abstract：:Interleukin-17A (IL-17A) is a major mediator of tissue inflammation in many autoimmune diseases. Anti-IL-17A is an effective treatment for psoriasis and is showing promise in clinical trials in multiple sclerosis. In this study, we find that IL-17A-defective mice or mice treated with anti-IL-17A at induction of experi...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.01.002
更新日期：2020-02-18 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral ...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2018.12.027
更新日期：2019-01-15 00:00:00
abstract：:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.07.014
更新日期：2018-10-16 00:00:00
abstract：:A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitme...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.07.018
更新日期：2010-08-27 00:00:00
abstract：:The c-Myb transcription factor is crucial during definitive hematopoiesis. However, the embryonic lethality of Myb traditional null mutations has precluded analysis of c-Myb function in lymphocytes. Using tissue-specific inactivation at the Myb locus, we demonstrate that loss of Myb causes a partial block during B cel...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2005.08.005
更新日期：2005-09-01 00:00:00
abstract：:The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2006.09.004
更新日期：2006-10-01 00:00:00
abstract：:mTORC2 is a metabolic regulatory complex activated by PI3K. In this issue of Immunity, Kishore et al. (2017) demonstrate a specialized role for this complex in the migration of regulatory T (Treg) cells to sites of inflammation rather than their differentiation and survival. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2017.11.006
更新日期：2017-11-21 00:00:00
abstract：:Few apoptotic corpses are seen even in tissues with high cellular turnover, leading to the notion that the capacity for engulfment in vivo is vast. Whether corpse clearance can be enhanced in vivo for potential benefit is not known. In a colonic inflammation model, we noted that the expression of the phagocytic recept...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2016.02.005
更新日期：2016-04-19 00:00:00
abstract：:The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we ...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2007.10.002
更新日期：2007-10-01 00:00:00
abstract：:CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy....
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2014.11.005
更新日期：2014-11-20 00:00:00
abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.07.001
更新日期：2010-07-23 00:00:00
abstract：:Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2016.03.015
更新日期：2016-04-19 00:00:00
abstract：:Antigen-dependent T cell activation drives the formation of signaling microclusters containing the adaptor SLP-76. Costimulatory integrins regulate SLP-76 phosphorylation and could influence SLP-76 microclusters in the integrin-rich periphery of the immune synapse. We report that costimulation by the integrin VLA-4 (a...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2008.04.019
更新日期：2008-06-01 00:00:00
abstract：:The thymus generates major histocompatibility complex (MHC)-restricted alphabetaT cells that only recognize antigenic ligands in association with MHC or MHC-like molecules. We hypothesized that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2007.10.007
更新日期：2007-11-01 00:00:00
abstract：:Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.03.022
更新日期：2018-04-17 00:00:00
abstract：:In this issue of Immunity, Anderson et al. provide another clue to the riddle that is Aire--why do human beings and mice lacking Aire develop diffuse and pathogenic autoimmunity? They find that Aire influences central tolerance not only by promoting the expression of peripheral self-proteins in thymic medullary epithe...
journal_title：Immunity
pub_type： 评论,杂志文章,评审
doi：10.1016/j.immuni.2005.08.004
更新日期：2005-08-01 00:00:00
abstract：:Recent evidence has suggested that signals other than those from Toll-like receptors (TLRs) could contribute to the elicitation of antigen-specific immunity. Therefore, we examined the role of the Nod-like receptor (NLR) family member, Nod1, in the generation of adaptive immune responses. Our findings show that innate...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2007.03.009
更新日期：2007-04-01 00:00:00
abstract：:Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2018.08.023
更新日期：2018-09-18 00:00:00
abstract：:Murine natural killer cells selectively express members of the Ly49 family of class I MHC receptors; however, the molecular mechanism controlling probabilistic expression of Ly49 proteins has not been defined. A pair of overlapping, divergent promoters discovered in the Ly49g gene functions as a molecular switch that ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2004.06.005
更新日期：2004-07-01 00:00:00
abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(04)00107-4
更新日期：2004-05-01 00:00:00
abstract：:Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of various cytoplasmic structures, including damaged organelles and invading microorganisms. Autophagy not only represents an essential cell-intrinsic mechanism to protect against internal and external stress conditions but also shapes c...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2013.07.017
更新日期：2013-08-22 00:00:00
abstract：:Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(94)90070-1
更新日期：1994-08-01 00:00:00
abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80245-9
更新日期：1997-01-01 00:00:00
abstract：:The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2015.04.010
更新日期：2015-05-19 00:00:00
abstract：:The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.06.012
更新日期：2020-07-14 00:00:00
abstract：:Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2014.12.027
更新日期：2015-01-20 00:00:00
abstract：:The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss of Caspase-8 or FAD...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2016.07.016
更新日期：2016-09-20 00:00:00
abstract：:The cause of common polygenic autoimmune diseases is not understood because of genetic and cellular complexity. Here, we pinpoint the action of a subset of autoimmune susceptibility loci in the NOD mouse strain linked to D1mit181, D2mit490, D7mit101, and D15mit229, which cause a generalized resistance to thymic deleti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2004.10.014
更新日期：2004-12-01 00:00:00
abstract：:Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00300-x
更新日期：2002-04-01 00:00:00
