Abstract:
:Murine natural killer cells selectively express members of the Ly49 family of class I MHC receptors; however, the molecular mechanism controlling probabilistic expression of Ly49 proteins has not been defined. A pair of overlapping, divergent promoters discovered in the Ly49g gene functions as a molecular switch that can produce a forward transcript containing the coding region of the gene (on position) or a noncoding transcript in the opposite direction (off position), and this element maintains transcription in the chosen direction. Competition of C/EBP and TBP transcription factors for overlapping binding sites determines the relative strength of the competing promoters and the probability of transcription in a given direction. Similar elements precede all Ly49 family members, and the relative strength of the forward promoter in each inhibitory Ly49 gene correlates with the percentage of natural killer cells that express a given receptor, supporting a promoter competition model of selective gene activation.
journal_name
Immunityjournal_title
Immunityauthors
Saleh A,Davies GE,Pascal V,Wright PW,Hodge DL,Cho EH,Lockett SJ,Abshari M,Anderson SKdoi
10.1016/j.immuni.2004.06.005keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
55-66issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(04)00169-4journal_volume
21pub_type
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