Abstract：
:Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced expression of the E3 ubiquitin ligase Pellino3 in human abdominal adipose tissue from obese subjects and in adipose tissue of mice fed a high-fat diet and showing signs of insulin resistance. Pellino3-deficient mice demonstrated exacerbated high-fat-diet-induced inflammation, IL-1β expression, and insulin resistance. Mechanistically, Pellino3 negatively regulated TNF receptor associated 6 (TRAF6)-mediated ubiquitination and stabilization of hypoxia-inducible factor 1α (HIF1α), resulting in reduced HIF1α-induced expression of IL-1β. Our studies identify a regulatory mechanism controlling diet-induced insulin resistance by highlighting a critical role for Pellino3 in regulating IL-1β expression with implications for diseases like type 2 diabetes.
journal_name
Immunityjournal_title
Immunityauthors
Yang S,Wang B,Humphries F,Hogan AE,O'Shea D,Moynagh PNdoi
10.1016/j.immuni.2014.11.013subject
Has Abstractpub_date
2014-12-18 00:00:00pages
973-87issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(14)00441-5journal_volume
41pub_type
杂志文章相关文献
IMMUNITY文献大全abstract：:The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory responses that promote the rapid clearance of pathogens but also contribute to pathology in chronic inflammation. Therapeutic interventions manipulating these cytokines are approved for use in some cancers as well as allergic and autoimmu...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2019.03.022
更新日期：2019-04-16 00:00:00
abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.07.020
更新日期：2020-09-15 00:00:00
abstract：:To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(02)00480-6
更新日期：2002-12-01 00:00:00
abstract：:The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were i...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2006.03.011
更新日期：2006-05-01 00:00:00
abstract：:In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2015.05.002
更新日期：2015-05-19 00:00:00
abstract：:Immunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We als...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2009.01.006
更新日期：2009-03-20 00:00:00
abstract：:Commensal microbiota confers a goldilocks state of alertness to pathogens, yet restrains deleterious inflammation. In this issue of Immunity, Geuking et al. (2011) demonstrate that a minimal bacterial community of the Schaedler flora establishes a balance between pro- and anti-inflammatory T cells in the gut. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2011.05.008
更新日期：2011-05-27 00:00:00
abstract：:Plasmacytoid dendritic cells (pDCs) are a unique sentinel cell type that can detect pathogen-derived nucleic acids and respond with rapid and massive production of type I interferon. This review summarizes our current understanding of pDC biology, including transcriptional regulation, heterogeneity, role in antiviral ...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2018.12.027
更新日期：2019-01-15 00:00:00
abstract：:By virtue of its ability to couple the BCR to an inhibitory pathway, FcgammaRIIB can potentially determine the fate of B cells upon IgG immune complex engagement. We now provide evidence for FcgammaRIIB as a component of a peripheral tolerance pathway with the observation that RIIB-/- mice develop autoantibodies and a...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)00027-3
更新日期：2000-08-01 00:00:00
abstract：:Tissue-selective trafficking of memory and effector T and B lymphocytes is mediated by unique combinations of adhesion molecules and chemokines. The discovery of several related epithelial-expressed chemokines (TECK/CCL25 in small intestine, CTACK/CCL27 in skin, and MEC/CCL28 in diverse mucosal sites) now highlights a...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/s1074-7613(01)00261-8
更新日期：2002-01-01 00:00:00
abstract：:Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.01.006
更新日期：2018-02-20 00:00:00
abstract：:Natural killer (NK) cells show some features of adaptive immunity but have not been studied at the clonal level. Here, we used retrogenic color-barcoding and single-cell adoptive transfers to track clonal immune responses to murine cytomegalovirus (MCMV) infection, derived from individual NK cells expressing activatin...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2019.04.015
更新日期：2019-06-18 00:00:00
abstract：:Epstein-Barr virus (EBV) establishes a persistent latent infection in peripheral B lymphocytes in humans and is associated with a variety of malignancies and proliferative disorders. Latent membrane protein 2A (LMP2A) is one of only two viral proteins expressed in latently infected B lymphocytes in vivo. LMP2A blocks ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80623-8
更新日期：1998-09-01 00:00:00
abstract：:Cytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates all cell types involved in the initiation, propagation, and resolution of inflammation. Here, we focus on Jak-Stat signaling in three major cell types involved in inflammatory responses: T cells, neutrophils, and macrop...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2008.03.002
更新日期：2008-04-01 00:00:00
abstract：:Sterile inflammation can be initiated by innate immune recognition of markers of tissue injury termed damage-associated molecular patterns (DAMPs). DAMP recognition by dendritic cells (DCs) has also been postulated to lead to T cell responses to foreign antigens in tumors or allografts. Many DAMPs represent intracellu...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2012.03.008
更新日期：2012-04-20 00:00:00
abstract：:HS1, the leukocyte-specific homolog of cortactin, regulates F-actin in vitro and is phosphorylated in response to TCR ligation, but its role in lymphocyte activation has not been addressed. We demonstrate that HS1-deficient T cells fail to accumulate F-actin at the immune synapse (IS) and, upon TCR ligation, form acti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2006.03.022
更新日期：2006-06-01 00:00:00
abstract：:For a preferential homing of T cells to the gut, expression of the integrin alpha4beta7 and the chemokine receptor CCR9 is essential and is induced by antigenic stimulation with dendritic cells from the gut-associated lymphoid organs. Here, we show that the vitamin A (retinol) metabolite, retinoic acid, enhances the e...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2004.08.011
更新日期：2004-10-01 00:00:00
abstract：:Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10 years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular helper (Tfh) differentiation and the requirement of Tfh cells as the specialized subset of CD4+ T cells needed for germinal center...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2019.04.011
更新日期：2019-05-21 00:00:00
abstract：:Fas receptor-induced apoptosis plays critical roles in immune homeostasis. However, most of the signal transduction events distal to Fas ligation have not been elucidated. Here, we show that Ras is activated following ligation of Fas on lymphoid lines. The activation of Ras is a critical component of this apoptotic pa...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/1074-7613(95)90142-6
更新日期：1995-04-01 00:00:00
abstract：:A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell receptor; however, the role of signals transduced by other cell surfa...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80275-7
更新日期：1996-12-01 00:00:00
abstract：:In this issue of Immunity, Duprez et al. (2011) demonstrate that necroptosis, a form of regulated necrosis that is mediated by the kinases RIPK1 and RIPK3, underlies the lethal effects of tumor necrosis factor in vivo. ...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2011.12.004
更新日期：2011-12-23 00:00:00
abstract：:Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2010.07.001
更新日期：2010-07-23 00:00:00
abstract：:Interleukin-1 (IL-1) receptor signaling is necessary for control of Mycobacterium tuberculosis (Mtb) infection, yet the role of its two ligands, IL-1α and IL-1β, and their regulation in vivo are poorly understood. Here, we showed that both IL-1α and IL-1β are critically required for host resistance and identified two ...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2011.12.002
更新日期：2011-12-23 00:00:00
abstract：:A cDNA clone encoding the human homolog of rat Jagged1 was isolated from normal human marrow. Analyses of human stromal cell lines indicate that this gene, designated hJagged1, is expressed by marrow stromal cells typified by the cell line HS-27a, which supports the long-term maintenance of hematopoietic progenitor ce...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80457-4
更新日期：1998-01-01 00:00:00
abstract：:Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...
journal_title：Immunity
pub_type： 杂志文章,评审
doi：10.1016/j.immuni.2005.11.010
更新日期：2006-01-01 00:00:00
abstract：:Transcription factors of the NFAT family play a critical role in the immune response by activating the expression of cytokines and other inducible genes in antigen-stimulated cells. Here we show that a member of this family, NFAT1, is involved in down-regulating the late phase of IL-4 gene transcription, thus inhibiti...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/s1074-7613(00)80403-3
更新日期：1997-12-01 00:00:00
abstract：:The intestinal microbiota shapes and directs immune development locally and systemically, but little is known about whether commensal microbes in the stomach can impact their immunological microenvironment. Here, we report that group 2 innate lymphoid cells (ILC2s) were the predominant ILC subset in the stomach and sh...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2020.03.002
更新日期：2020-04-14 00:00:00
abstract：:Pancreatic adenocarcinoma (PDAC) is mostly refractory to immunotherapies. In this issue of Immunity, Li et al. (2018) generate a library of clonal PDAC tumors to examine the tumor-intrinsic features shaping the anti-tumor immune response and find that tumor cell-derived CXCL1 directly blunts T cell infiltration and re...
journal_title：Immunity
pub_type： 评论,杂志文章
doi：10.1016/j.immuni.2018.07.001
更新日期：2018-07-17 00:00:00
abstract：:CD4+ T helper (Th) differentiation is regulated by diverse inputs, including the vitamin A metabolite retinoic acid (RA). RA acts through its receptor RARα to repress transcription of inflammatory cytokines, but is also essential for Th-mediated immunity, indicating complex effects of RA on Th specification and the ou...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2018.12.014
更新日期：2019-01-15 00:00:00
abstract：:The participation of a specific subset of B cells and how they are regulated in cancer is unclear. Here, we demonstrate that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors. CD5(+) B cells responded to IL-6 in the absence of IL-6Rα. IL-6 directl...
journal_title：Immunity
pub_type： 杂志文章
doi：10.1016/j.immuni.2016.04.003
更新日期：2016-04-19 00:00:00
