Abstract:
:Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we analyzed the response to H7N9 vaccination in H7N9-naive adults. We performed comprehensive comparisons at the single-cell level of the kinetics, Ig repertoire, and activation phenotype of established pre-existing memory B cells recognizing conserved epitopes and the newly generated memory B cells directed toward H7 strain-specific epitopes. The recall response to conserved epitopes on H7 HA involved a transient expansion of memory B cells with little observed adaptation. However, the B cell response to newly encountered epitopes was phenotypically distinct and generated a sustained memory population that evolved and affinity matured months after vaccination. These findings establish clear differences between newly generated and pre-existing memory B cells, highlighting the challenges in achieving long-lasting, broad protection against an ever-evolving virus.
journal_name
Immunityjournal_title
Immunityauthors
Andrews SF,Chambers MJ,Schramm CA,Plyler J,Raab JE,Kanekiyo M,Gillespie RA,Ransier A,Darko S,Hu J,Chen X,Yassine HM,Boyington JC,Crank MC,Chen GL,Coates E,Mascola JR,Douek DC,Graham BS,Ledgerwood JE,McDermott ABdoi
10.1016/j.immuni.2019.06.024subject
Has Abstractpub_date
2019-08-20 00:00:00pages
398-410.e5issue
2eissn
1074-7613issn
1097-4180pii
S1074-7613(19)30294-8journal_volume
51pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80123-5
更新日期:1999-10-01 00:00:00
abstract::Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.11.002
更新日期:2016-11-15 00:00:00
abstract::Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LC...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.07.013
更新日期:2008-09-19 00:00:00
abstract::Previous in vitro studies defined the minimal regions of RAG1 and RAG2 essential for V(D)J recombination. In order to characterize the role of the C-terminal "dispensable" portion of RAG2, we generated core-RAG2 knock-in mice. We found that the core-RAG2-containing recombinase complex is selectively defective in catal...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00448-x
更新日期:2002-11-01 00:00:00
abstract::The mechanism by which regulatory T cells control the germinal center response is unknown. In this issue of Immunity, Wing et al. (2014) and Sage et al. (2014) demonstrate that CTLA-4 is a critical effector molecule used by regulatory T cells to control the germinal center. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.12.009
更新日期:2014-12-18 00:00:00
abstract::Proliferation of memory-phenotype (CD44hi) CD8+ cells induced by infectious agents can be mimicked by injection of type I interferon (IFN I) and by IFN I-inducing agents such as lipopolysaccharide and Poly I:C; such proliferation does not affect naive T cells and appears to be TCR independent. Since IFN I inhibits pro...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80564-6
更新日期:1998-05-01 00:00:00
abstract::Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.027
更新日期:2015-01-20 00:00:00
abstract::Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retent...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00281-9
更新日期:2002-03-01 00:00:00
abstract::The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of pDCs is actively maintained in the s...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.11.023
更新日期:2010-12-14 00:00:00
abstract::Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct condu...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/s1074-7613(03)00303-0
更新日期:2003-11-01 00:00:00
abstract::Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2015.09.008
更新日期:2015-10-20 00:00:00
abstract::Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...
journal_title:Immunity
pub_type: 信件
doi:10.1016/j.immuni.2009.09.007
更新日期:2009-10-16 00:00:00
abstract::To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80090-4
更新日期:1999-08-01 00:00:00
abstract::Immunoglobulin G (IgG) antibodies confer protection against pathogenic microorganisms, serve as therapeutics in tumor therapy, and are involved in destruction of healthy tissues during autoimmune diseases. Understanding the molecular pathways and effector cell types involved in antibody-mediated effector functions is ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.11.009
更新日期:2011-12-23 00:00:00
abstract::CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis. This asymmetry in outcome of infection between the two knockout strains is likely due ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00324-8
更新日期:2003-12-01 00:00:00
abstract::Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.08.004
更新日期:2013-09-19 00:00:00
abstract::The Ikaros gene family encodes zinc finger DNA-binding proteins essential for lineage determination and control of proliferation in the lymphoid system. Here, we report that, in the nucleus of a T cell, a major fraction of Ikaros and Aiolos proteins associate with the DNA-dependent ATPase Mi-2 and histone deacetylases...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80034-5
更新日期:1999-03-01 00:00:00
abstract::Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4(+)FoxP3(+) T regulatory (Treg) cell survival and T helper 17 (Th17) cell proliferation. Here, we analyzed the costimulatory requirements for the induction of Th9 cells, and demonstrated that Notch pathway ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.01.020
更新日期:2012-04-20 00:00:00
abstract::In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2007.11.003
更新日期:2007-11-01 00:00:00
abstract::Monocytes are effectors of the inflammatory response to microbes. Human CD14(+) monocytes specialize in phagocytosis and production of reactive oxygen species and secrete inflammatory cytokines in response to a broad range of microbial cues. Here, we have characterized the functions of human monocytes that lack CD14 (...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.08.012
更新日期:2010-09-24 00:00:00
abstract::The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential effectors in TNF signaling. To understand the mechanism by which RIP and TRAF2 regulate TNF-induced activation of the transcription factor NF-kappaB, we investigated their respective roles in TNF-R1-mediated IKK activation using...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80194-6
更新日期:2000-04-01 00:00:00
abstract::Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.04.018
更新日期:2017-05-16 00:00:00
abstract::Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00210-2
更新日期:2001-10-01 00:00:00
abstract::HS1, the leukocyte-specific homolog of cortactin, regulates F-actin in vitro and is phosphorylated in response to TCR ligation, but its role in lymphocyte activation has not been addressed. We demonstrate that HS1-deficient T cells fail to accumulate F-actin at the immune synapse (IS) and, upon TCR ligation, form acti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.03.022
更新日期:2006-06-01 00:00:00
abstract::Dendritic cell (DC) activation is essential for the induction of immune defense against pathogens, yet needs to be tightly controlled to avoid chronic inflammation and exaggerated immune responses. Here, we identify a mechanism of immune homeostasis by which adaptive immunity, once triggered, tempers DC activation and...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.06.010
更新日期:2013-07-25 00:00:00
abstract::The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90146-9
更新日期:1995-04-01 00:00:00
abstract::Recognition of major histocompatibility class I molecules on target cells by natural killer (NK) cells confers selective protection from NK-mediated lysis. Cross-linking of the p58 NK receptor, involved in the recognition of HLA-C alleles, delivers a negative signal that prevents target cell lysis. Molecular cloning o...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90025-x
更新日期:1995-05-01 00:00:00
abstract::Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.020
更新日期:2015-01-20 00:00:00
abstract::NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2009.05.005
更新日期:2009-06-19 00:00:00
abstract::Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.04.015
更新日期:2012-08-24 00:00:00