Abstract：
:To examine the role of the TNF-R superfamily signaling protein TRAF2 in mature B cell development and NF-kappaB activation, conditionally TRAF2-deficient mice were produced. B cells lacking TRAF2 expression in these mice possessed a selective survival advantage, accumulated in the lymph nodes and splenic marginal zone, were larger in size, and expressed increased levels of CD21/35. These TRAF2-deficient B cells could not proliferate or activate the canonical NF-kappaB pathway in response to CD40 ligation. By contrast, noncanonical NF-kappaB activation was constitutively hyperactive, with TRAF2-deficient B cells exhibiting close to maximal processing of NF-kappaB2 from p100 to p52 and high levels of constitutive p52 and RelB DNA binding activity. These findings establish TRAF2 as a multifunctional regulator of NF-kappaB activation that mediates activation of the canonical pathway but acts as a negative regulator of the noncanonical pathway. This dual functionality explains the contrasting roles of TRAF2 in B cell maturation and activation.
journal_name
Immunityjournal_title
Immunityauthors
Grech AP,Amesbury M,Chan T,Gardam S,Basten A,Brink Rdoi
10.1016/j.immuni.2004.09.011keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
629-42issue
5eissn
1074-7613issn
1097-4180pii
S1074-7613(04)00302-4journal_volume
21pub_type
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