Abstract：
:When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially in cells of epithelial origin, recent studies have defined additional antiviral mechanisms in other cell types and tissues. Viral infection models using mice lacking IFN-λ signaling and SNP associations with human disease have expanded our understanding of the contribution of IFN-λ to the antiviral response at anatomic barriers and the immune response beyond these barriers. In this review, we highlight recent insights into IFN-λ functions, including its ability to restrict virus spread into the brain and to clear chronic viral infections in the gastrointestinal tract. We also discuss how IFN-λ modulates innate and adaptive immunity, autoimmunity, and tumor progression and its possible therapeutic applications in human disease.
journal_name
Immunityjournal_title
Immunityauthors
Lazear HM,Nice TJ,Diamond MSdoi
10.1016/j.immuni.2015.07.001subject
Has Abstractpub_date
2015-07-21 00:00:00pages
15-28issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(15)00268-Xjournal_volume
43pub_type
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