The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

journal_title：Immunity

authors： Pascual-Gil S,Epelman S

更新日期：2018-11-20 00:00:00

abstract：:To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...

journal_title：Immunity

authors： Spiotto MT,Yu P,Rowley DA,Nishimura MI,Meredith SC,Gajewski TF,Fu YX,Schreiber H

更新日期：2002-12-01 00:00:00

abstract：:By virtue of its ability to couple the BCR to an inhibitory pathway, FcgammaRIIB can potentially determine the fate of B cells upon IgG immune complex engagement. We now provide evidence for FcgammaRIIB as a component of a peripheral tolerance pathway with the observation that RIIB-/- mice develop autoantibodies and a...

journal_title：Immunity

authors： Bolland S,Ravetch JV

更新日期：2000-08-01 00:00:00

abstract：:We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the present...

journal_title：Immunity

authors： Prigozy TI,Sieling PA,Clemens D,Stewart PL,Behar SM,Porcelli SA,Brenner MB,Modlin RL,Kronenberg M

更新日期：1997-02-01 00:00:00

abstract：:microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lackin...

journal_title：Immunity

authors： Vigorito E,Perks KL,Abreu-Goodger C,Bunting S,Xiang Z,Kohlhaas S,Das PP,Miska EA,Rodriguez A,Bradley A,Smith KG,Rada C,Enright AJ,Toellner KM,Maclennan IC,Turner M

更新日期：2007-12-01 00:00:00

abstract：:To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...

journal_title：Immunity

authors： Chen J,Stewart V,Spyrou G,Hilberg F,Wagner EF,Alt FW

更新日期：1994-04-01 00:00:00

abstract：:CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained u...

journal_title：Immunity

authors： Cannons JL,Qi H,Lu KT,Dutta M,Gomez-Rodriguez J,Cheng J,Wakeland EK,Germain RN,Schwartzberg PL

更新日期：2010-02-26 00:00:00

abstract：:The ability of human CD1b molecules to present nonpeptide antigens is suggested by the T cell recognition of microbial lipids and lipoglycans in the presence of CD1b-expressing antigen-presenting cells. We demonstrate the high-affinity interaction of CD1b molecules with the acyl side chains of known T cell antigens, l...

journal_title：Immunity

authors： Ernst WA,Maher J,Cho S,Niazi KR,Chatterjee D,Moody DB,Besra GS,Watanabe Y,Jensen PE,Porcelli SA,Kronenberg M,Modlin RL

更新日期：1998-03-01 00:00:00

abstract：:Stat6 is critical for IL-4-mediated Th2 cell development, but its molecular mechanism remains unclear. Here we constructed Stat6:ER, a Stat6-estrogen receptor fusion protein that can be activated by 4-hydroxy-tamoxifen, independently of IL-4 and endogenous Stat6. Retrovirus-mediated introduction of Stat6:ER into devel...

journal_title：Immunity

authors： Kurata H,Lee HJ,O'Garra A,Arai N

更新日期：1999-12-01 00:00:00

abstract：:Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killi...

journal_title：Immunity

authors： Mocikat R,Braumüller H,Gumy A,Egeter O,Ziegler H,Reusch U,Bubeck A,Louis J,Mailhammer R,Riethmüller G,Koszinowski U,Röcken M

更新日期：2003-10-01 00:00:00

abstract：:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c ad...

journal_title：Immunity

authors： Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

更新日期：1998-06-01 00:00:00

abstract：:Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

journal_title：Immunity

authors： Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

更新日期：2017-12-19 00:00:00

abstract：:C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...

journal_title：Immunity

authors： Pewe L,Wu GF,Barnett EM,Castro RF,Perlman S

更新日期：1996-09-01 00:00:00

abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

journal_title：Immunity

authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

更新日期：2005-02-01 00:00:00

abstract：:Why patients with chronic kidney disease have elevated cardiovascular risk remains elusive. In this issue of Immunity, Speer et al. (2013) show that natural modification of high density lipoprotein promotes hypertension through a Toll-like receptor-dependent mechanism. ...

journal_title：Immunity

authors： Moore KJ,Fisher EA

更新日期：2013-04-18 00:00:00

abstract：:MicroRNAs have been shown to be critical for a number of aspects of immune system regulation and function. Here, we have examined the role of microRNAs in terminal B cell differentiation by analyzing Cd19-Cre(ki/+) Dicer1(fl/fl) mice. We found that in the absence of Dicer, the transitional and marginal zone (MZ) B cel...

journal_title：Immunity

authors： Belver L,de Yébenes VG,Ramiro AR

更新日期：2010-11-24 00:00:00

abstract：:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) i...

journal_title：Immunity

authors： Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

更新日期：2001-11-01 00:00:00

abstract：:The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...

journal_title：Immunity

authors： Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

更新日期：2018-06-19 00:00:00

abstract：:HLA-DM (DM) is a nonclassical MHC class II molecule that interacts with classical MHC II molecules in acidic compartments. During this association DM is supposed to catalyze the release of invariant chain (Ii)-derived CLIP peptides, as well as other peptides bound with low kinetic stability. Here we provide evidence t...

journal_title：Immunity

authors： Kropshofer H,Arndt SO,Moldenhauer G,Hämmerling GJ,Vogt AB

更新日期：1997-03-01 00:00:00

abstract：:Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous defense against intracellular pathogens. Here, we screened the Rab family of membrane trafficking regulators for effects on autophagic elimination of Mycobacterium...

journal_title：Immunity

authors： Pilli M,Arko-Mensah J,Ponpuak M,Roberts E,Master S,Mandell MA,Dupont N,Ornatowski W,Jiang S,Bradfute SB,Bruun JA,Hansen TE,Johansen T,Deretic V

更新日期：2012-08-24 00:00:00

abstract：:We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, sup...

journal_title：Immunity

authors： Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B

更新日期：2006-02-01 00:00:00

abstract：:Notch signaling has been identified as an important regulator of leukocyte differentiation and thymic maturation. Less is known about the role of Notch signaling in regulating mature T cells. We examined the role of Notch 1 in regulating peripheral T cell activity in vitro and in vivo. Coligation of Notch 1 together w...

journal_title：Immunity

authors： Eagar TN,Tang Q,Wolfe M,He Y,Pear WS,Bluestone JA

更新日期：2004-04-01 00:00:00

abstract：:The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation. ...

journal_title：Immunity

authors： Hagman J,Lukin K

更新日期：2007-07-01 00:00:00

abstract：:The integrin alpha9beta1 is widely expressed on neutrophils, smooth muscle, hepatocytes, endothelia, and some epithelia. We now show that mice lacking this integrin have a dramatic defect in neutrophil development, with decreased numbers of granulocyte precursors in bone marrow and impaired differentiation of bone mar...

journal_title：Immunity

authors： Chen C,Huang X,Atakilit A,Zhu QS,Corey SJ,Sheppard D

更新日期：2006-12-01 00:00:00

abstract：:Three mutant immunoglobulin heavy chain (IgH) insertion mice were generated in which a targeted nonfunctional IgH passenger transgene was either devoid of promoter (pdelta) or was placed under the transcriptional control of either its own RNA polymerase II-dependent IgH promoter (pII) or a RNA polymerase I-dependent p...

journal_title：Immunity

authors： Fukita Y,Jacobs H,Rajewsky K

更新日期：1998-07-01 00:00:00

abstract：:Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice. ...

journal_title：Immunity

authors： Soares MP

更新日期：2014-08-21 00:00:00

abstract：:Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasi...

journal_title：Immunity

authors： Boyle MJ,Reiling L,Feng G,Langer C,Osier FH,Aspeling-Jones H,Cheng YS,Stubbs J,Tetteh KK,Conway DJ,McCarthy JS,Muller I,Marsh K,Anders RF,Beeson JG

更新日期：2015-03-17 00:00:00

abstract：:Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...

journal_title：Immunity

authors： Zhang L,Mo J,Swanson KV,Wen H,Petrucelli A,Gregory SM,Zhang Z,Schneider M,Jiang Y,Fitzgerald KA,Ouyang S,Liu ZJ,Damania B,Shu HB,Duncan JA,Ting JP

更新日期：2014-03-20 00:00:00

abstract：:The antigen receptor for natural killer T cells (NKT TCR) binds CD1d-restricted microbial and self-lipid antigens, although the molecular basis of self-CD1d recognition is unclear. Here, we have characterized NKT TCR recognition of CD1d molecules loaded with natural self-antigens (Ags) and report the 2.3 Å resolution ...

journal_title：Immunity

authors： Mallevaey T,Clarke AJ,Scott-Browne JP,Young MH,Roisman LC,Pellicci DG,Patel O,Vivian JP,Matsuda JL,McCluskey J,Godfrey DI,Marrack P,Rossjohn J,Gapin L

更新日期：2011-03-25 00:00:00

abstract：:Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...

journal_title：Immunity

authors： Green EA,Choi Y,Flavell RA

更新日期：2002-02-01 00:00:00