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Generation of normal T and B lymphocytes by c-jun deficient embryonic stem cells.

Abstract：

:To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantial numbers of mature T and B lymphocytes in the periphery. Stimulation of c-jun-/- B cells resulted in normal levels of proliferation and immunoglobulin secretion. Likewise, stimulation of c-jun-/- T cells resulted in essentially normal levels of IL-2R alpha expression, IL-2 secretion, and proliferation. We further showed that the relatively normal activation responses of the c-jun-/- T cells probably results from the fact that other members of the Jun family contribute to the bulk of the activator protein-1 (AP-1) complexes in normal T cells and, as a result, AP-1 complexes are found at relatively normal levels in c-jun-/- T cells.

journal_name

Immunity

journal_title

Immunity

authors

Chen J,Stewart V,Spyrou G,Hilberg F,Wagner EF,Alt FW

doi

10.1016/1074-7613(94)90010-8

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

65-72

issue

1

eissn

1074-7613

issn

1097-4180

pii

1074-7613(94)90010-8

journal_volume

1

pub_type

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