Abstract:
:Genetic predisposition plays a crucial role in susceptibility to systemic lupus erythematosus (SLE) in both human patients and animal models. Recent progress in experimental systems and human linkage analysis is providing key insights into the genetic basis for susceptibility and elucidating the manner in which genetic interactions mediate severe disease pathogenesis. Genes in multiple pathways appear to participate in specific elements of the disease, and epistatic interactions among these genes play an important role in both aggravating and suppressing disease development.
journal_name
Immunityjournal_title
Immunityauthors
Wakeland EK,Liu K,Graham RR,Behrens TWdoi
10.1016/s1074-7613(01)00201-1keywords:
subject
Has Abstractpub_date
2001-09-01 00:00:00pages
397-408issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(01)00201-1journal_volume
15pub_type
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