Abstract:
:Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retrovirus, HERV-K18, that possesses SAg activity. SAg activity was demonstrated by MHC class II dependent preferential activation of TCRVB13 T cells in response to murine B cells transfected with the HERV-K18 env gene. This is a unique demonstration of a pathogen inducing a host-encoded Sag and accounts for the previously described EBV associated Sag activity. The T cell activation elicited by the Sag could play a central role in EBV infection and associated diseases.
journal_name
Immunityjournal_title
Immunityauthors
Sutkowski N,Conrad B,Thorley-Lawson DA,Huber BTdoi
10.1016/s1074-7613(01)00210-2keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
579-89issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(01)00210-2journal_volume
15pub_type
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