Abstract:
:B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within approximately 2- to 3-fold) overall receptor binding and T cell costimulatory properties as CD80. However, CD80 and CD86 did not bind equivalently to CTLA-4: CD80 bound Y100A, a form of CTLA4lg with a mutation in the CDR3-like region, > 200-fold better than did CD86; inhibition of CD80-mediated cellular responses required approximately 100-fold lower CTLA4lg concentrations; and CD80-CTLA4lg complexes dissociated 5- to 8-fold more slowly, Thus, CD80 and CD86 utilize different binding determinants and have different kinetics of binding to CD28 and CTLA-4.
journal_name
Immunityjournal_title
Immunityauthors
Linsley PS,Greene JL,Brady W,Bajorath J,Ledbetter JA,Peach Rdoi
10.1016/s1074-7613(94)80021-9subject
Has Abstractpub_date
1994-12-01 00:00:00pages
793-801issue
9eissn
1074-7613issn
1097-4180pii
S1074-7613(94)80021-9journal_volume
1pub_type
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