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CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor.

Abstract：

:CD4(+)CD25(+) immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function. We analyzed CD4(+)CD25(+) and CD4(+)CD25(-) T cells by DNA microarray, identifying 29 genes differentially expressed in the resting subpopulations, and 77 that were differentially expressed following activation. Most of these genes were elevated in the CD4(+)CD25(+) population, suggesting a previously activated phenotype. Among these were a number of genes that antagonize signaling, including members of the SOCS family, which may contribute to their anergic phenotype. Multiple cell surface receptors also had increased expression in CD4(+)CD25(+) cells, including GITR, a member of the TNF receptor superfamily. Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4(+)CD25(+) T cell subset.

journal_name

Immunity

journal_title

Immunity

authors

McHugh RS,Whitters MJ,Piccirillo CA,Young DA,Shevach EM,Collins M,Byrne MC

doi

10.1016/s1074-7613(02)00280-7

keywords:

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

311-23

issue

2

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00280-7

journal_volume

16

pub_type

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