当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > A Sweet Solution: Glycolysis-Dependent Treg Cell Migration.

A Sweet Solution: Glycolysis-Dependent Treg Cell Migration.

Abstract：

:mTORC2 is a metabolic regulatory complex activated by PI3K. In this issue of Immunity, Kishore et al. (2017) demonstrate a specialized role for this complex in the migration of regulatory T (Treg) cells to sites of inflammation rather than their differentiation and survival.

journal_name

Immunity

journal_title

Immunity

authors

Alon R

doi

10.1016/j.immuni.2017.11.006

subject

Has Abstract

pub_date

2017-11-21 00:00:00

pages

805-807

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(17)30483-1

journal_volume

47

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • The distal V(H) gene cluster of the Igh locus contains distinct regulatory elements with Pax5 transcription factor-dependent activity in pro-B cells.

    abstract：:V(H)-DJ(H) recombination of the immunoglobulin heavy chain (Igh) locus is temporally and spatially controlled during early B cell development, and yet no regulatory elements other than the V(H) gene promoters have been identified throughout the entire V(H) gene cluster. Here, we discovered regulatory sequences that ar...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.02.005

    authors： Ebert A,McManus S,Tagoh H,Medvedovic J,Salvagiotto G,Novatchkova M,Tamir I,Sommer A,Jaritz M,Busslinger M

    更新日期：2011-02-25 00:00:00

  • Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I.

    abstract：:The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process called "education." In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B(∗)27:05(+) transgenic m...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.07.005

    authors： Boudreau JE,Liu XR,Zhao Z,Zhang A,Shultz LD,Greiner DL,Dupont B,Hsu KC

    更新日期：2016-08-16 00:00:00

  • Viral infection results in massive CD8+ T cell expansion and mortality in vaccinated perforin-deficient mice.

    abstract：:Perforin-mediated cytotoxicity is essential for clearance of primary LCMV infection. BALB/c-perforin-deficient (PKO) mice survived LCMV infection by deleting NP(118)-specific CD8(+) T cells whereas vaccination of PKO mice with Listeria expressing NP(118) generated a stable memory CD8(+) T cell population. However, >85...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00079-7

    authors： Badovinac VP,Hamilton SE,Harty JT

    更新日期：2003-04-01 00:00:00

  • Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors.

    abstract：:B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that human CD86 maintains similar (within approximately 2- to 3-fold) overa...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(94)80021-9

    authors： Linsley PS,Greene JL,Brady W,Bajorath J,Ledbetter JA,Peach R

    更新日期：1994-12-01 00:00:00

  • Inflammasomes: Threat-Assessment Organelles of the Innate Immune System.

    abstract：:Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or downstream of inflammasome assembly, serving as the principal enzymes that control activities of these organelles. In this review, we discus...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2019.08.005

    authors： Evavold CL,Kagan JC

    更新日期：2019-10-15 00:00:00

  • FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

    abstract：:The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.04.010

    authors： Butt D,Chan TD,Bourne K,Hermes JR,Nguyen A,Statham A,O'Reilly LA,Strasser A,Price S,Schofield P,Christ D,Basten A,Ma CS,Tangye SG,Phan TG,Rao VK,Brink R

    更新日期：2015-05-19 00:00:00

  • Peeing pentraxins.

    abstract：:Antimicrobial agents secreted into urine potentially play a powerful role in the defense of the urinary tract. In this issue of Immunity, Jaillon et al. (2014) describe a role for pentraxin 3 molecules in complementing the host's cellular innate immune responses to uropathogens. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.03.006

    authors： Miao Y,Abraham SN

    更新日期：2014-04-17 00:00:00

  • Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses.

    abstract：:Regulatory T cells (Treg cells) perform suppressive functions in disparate tissue environments and against many inflammatory insults, yet the tissue-enriched factor(s) that influence Treg cell phenotype and function remain largely unknown. We have shown a vital role for transforming growth factor-β (TGF-β) signals in ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.03.015

    authors： Konkel JE,Zhang D,Zanvit P,Chia C,Zangarle-Murray T,Jin W,Wang S,Chen W

    更新日期：2017-04-18 00:00:00

  • The bug in MyD88 dependency.

    abstract：:The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2006.09.004

    authors： van Lier RA,Lutter R

    更新日期：2006-10-01 00:00:00

  • alpha beta T cell development is abolished in mice lacking both Lck and Fyn protein tyrosine kinases.

    abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80499-9

    authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

    更新日期：1996-11-01 00:00:00

  • Why aging T cells fail: implications for vaccination.

    abstract：:The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly. ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2006.06.003

    authors： Haynes L,Swain SL

    更新日期：2006-06-01 00:00:00

  • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

    abstract：:The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, wh...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.12.012

    authors： Miyao T,Floess S,Setoguchi R,Luche H,Fehling HJ,Waldmann H,Huehn J,Hori S

    更新日期：2012-02-24 00:00:00

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

    abstract：:Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.10.011

    authors： Sanin DE,Matsushita M,Klein Geltink RI,Grzes KM,van Teijlingen Bakker N,Corrado M,Kabat AM,Buck MD,Qiu J,Lawless SJ,Cameron AM,Villa M,Baixauli F,Patterson AE,Hässler F,Curtis JD,O'Neill CM,O'Sullivan D,Wu D,Mittler

    更新日期：2018-12-18 00:00:00

  • NKG2D blockade prevents autoimmune diabetes in NOD mice.

    abstract：:NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondep...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2004.05.008

    authors： Ogasawara K,Hamerman JA,Ehrlich LR,Bour-Jordan H,Santamaria P,Bluestone JA,Lanier LL

    更新日期：2004-06-01 00:00:00

  • Cytotoxic T cell-resistant variants are selected in a virus-induced demyelinating disease.

    abstract：:C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80320-9

    authors： Pewe L,Wu GF,Barnett EM,Castro RF,Perlman S

    更新日期：1996-09-01 00:00:00

  • Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

    abstract：:Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a model of spontaneous autoimmune arthritis, we showed that arthritogenic Th17 cells stimulated fibroblast-like synoviocytes via interleukin-17 (IL-17) to secrete...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.04.009

    authors： Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S

    更新日期：2018-06-19 00:00:00

  • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.

    abstract：:Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.12.027

    authors： Laky K,Evans S,Perez-Diez A,Fowlkes BJ

    更新日期：2015-01-20 00:00:00

  • T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.

    abstract：:Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6loCD69hi expressing a transcription factor IRF4 and higher-affinit...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.03.027

    authors： Ise W,Fujii K,Shiroguchi K,Ito A,Kometani K,Takeda K,Kawakami E,Yamashita K,Suzuki K,Okada T,Kurosaki T

    更新日期：2018-04-17 00:00:00

  • Inflammasome-Dependent Induction of Adaptive NK Cell Memory.

    abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.05.008

    authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

    更新日期：2016-06-21 00:00:00

  • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

    abstract：:Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxi...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.08.004

    authors： Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet W

    更新日期：2013-09-19 00:00:00

  • CD95-induced apoptosis of lymphocytes in an immune privileged site induces immunological tolerance.

    abstract：:We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80305-2

    authors： Griffith TS,Yu X,Herndon JM,Green DR,Ferguson TA

    更新日期：1996-07-01 00:00:00

  • The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

    abstract：:The cationic polysaccharide chitosan is an attractive candidate adjuvant capable of driving potent cell-mediated immunity, but the mechanism by which it acts is not clear. We show that chitosan promotes dendritic cell maturation by inducing type I interferons (IFNs) and enhances antigen-specific T helper 1 (Th1) respo...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.02.004

    authors： Carroll EC,Jin L,Mori A,Muñoz-Wolf N,Oleszycka E,Moran HBT,Mansouri S,McEntee CP,Lambe E,Agger EM,Andersen P,Cunningham C,Hertzog P,Fitzgerald KA,Bowie AG,Lavelle EC

    更新日期：2016-03-15 00:00:00

  • Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.

    abstract：:CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines. We analyzed presentation of NKT cell activating alpha galactosylceramide (alphaGalCer) analogs that give pr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.03.022

    authors： Im JS,Arora P,Bricard G,Molano A,Venkataswamy MM,Baine I,Jerud ES,Goldberg MF,Baena A,Yu KO,Ndonye RM,Howell AR,Yuan W,Cresswell P,Chang YT,Illarionov PA,Besra GS,Porcelli SA

    更新日期：2009-06-19 00:00:00

  • The costimulatory molecule CD27 maintains clonally diverse CD8(+) T cell responses of low antigen affinity to protect against viral variants.

    abstract：:CD70 and CD27 are costimulatory molecules that provide essential signals for the expansion and differentiation of CD8(+) T cells. Here, we show that CD27-driven costimulation lowered the threshold of T cell receptor activation on CD8(+) T cells and enabled responses against low-affinity antigens. Using influenza infec...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.04.020

    authors： van Gisbergen KP,Klarenbeek PL,Kragten NA,Unger PP,Nieuwenhuis MB,Wensveen FM,ten Brinke A,Tak PP,Eldering E,Nolte MA,van Lier RA

    更新日期：2011-07-22 00:00:00

  • Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development.

    abstract：:Invariant chain (Ii)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+ T cells. Many CD4+ T cells that do mature in Ii-negative mice express a cell surface phenotype consisten...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90120-5

    authors： Naujokas MF,Arneson LS,Fineschi B,Peterson ME,Sitterding S,Hammond AT,Reilly C,Lo D,Miller J

    更新日期：1995-09-01 00:00:00

  • Protein Tyrosine Phosphatase PTPRS Is an Inhibitory Receptor on Human and Murine Plasmacytoid Dendritic Cells.

    abstract：:Plasmacytoid dendritic cells (pDCs) are primary producers of type I interferon (IFN) in response to viruses. The IFN-producing capacity of pDCs is regulated by specific inhibitory receptors, yet none of the known receptors are conserved in evolution. We report that within the human immune system, receptor protein tyro...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.07.009

    authors： Bunin A,Sisirak V,Ghosh HS,Grajkowska LT,Hou ZE,Miron M,Yang C,Ceribelli M,Uetani N,Chaperot L,Plumas J,Hendriks W,Tremblay ML,Häcker H,Staudt LM,Green PH,Bhagat G,Reizis B

    更新日期：2015-08-18 00:00:00

  • Toll signaling in flies and mammals: two sorts of MyD88.

    abstract：:The mammalian MyD88 signaling molecule participates in Toll receptor signaling within the cytoplasm. In this issue of Immunity, Marek and Kagan (2012) report that Drosophila (d)MyD88 acts instead at the plasma membrane to sort the signaling adaptor Tube. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.04.001

    authors： Goto A,Imler JL

    更新日期：2012-04-20 00:00:00

  • SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.

    abstract：:The Toll-like receptor 3 (TLR3) and TLR4-signaling pathway that involves the adaptor protein TRIF activates type I interferon (IFN) and proinflammatory cytokine expression. Little is known about how TRIF pathway-dependent gene expression is regulated. SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a widely e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.10.014

    authors： An H,Zhao W,Hou J,Zhang Y,Xie Y,Zheng Y,Xu H,Qian C,Zhou J,Yu Y,Liu S,Feng G,Cao X

    更新日期：2006-12-01 00:00:00

  • Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.

    abstract：:The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs....

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.03.012

    authors： Chai Q,Onder L,Scandella E,Gil-Cruz C,Perez-Shibayama C,Cupovic J,Danuser R,Sparwasser T,Luther SA,Thiel V,Rülicke T,Stein JV,Hehlgans T,Ludewig B

    更新日期：2013-05-23 00:00:00

  • Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response.

    abstract：:To determine the site and mechanism of suppression by regulatory T (Treg) cells, we investigated their migration and function in an islet allograft model. Treg cells first migrated from blood to the inflamed allograft where they were essential for the suppression of alloimmunity. This process was dependent on the chem...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.12.022

    authors： Zhang N,Schröppel B,Lal G,Jakubzick C,Mao X,Chen D,Yin N,Jessberger R,Ochando JC,Ding Y,Bromberg JS

    更新日期：2009-03-20 00:00:00