当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Clec2d Joins the Cell Death Sensor Ranks.

Clec2d Joins the Cell Death Sensor Ranks.

Abstract：

:Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. In this issue of Immunity, Lai et al. (2020) uncover a role for the C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology.

journal_name

Immunity

journal_title

Immunity

authors

Del Fresno C,Sancho D

doi

10.1016/j.immuni.2019.12.015

subject

Has Abstract

pub_date

2020-01-14 00:00:00

pages

6-8

issue

1

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(19)30534-5

journal_volume

52

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells.

    abstract：:Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood. We show that the CXCL16-CXCR6 chemokine-chemokine receptor axis regulated group 3 innate lymphoid cell (ILC3) diversity and function. CXCL16 was constitutiv...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.10.007

    authors： Satoh-Takayama N,Serafini N,Verrier T,Rekiki A,Renauld JC,Frankel G,Di Santo JP

    更新日期：2014-11-20 00:00:00

  • CD4+ T cells rely on a cytokine gradient to control intracellular pathogens beyond sites of antigen presentation.

    abstract：:Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8(+) T cells, CD4(+) helper T cells have been shown to deliver effector molecules directionally toward the immunological synapse, suggesting that infected cells need to be engaged individually to receive effector signals...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.05.015

    authors： Müller AJ,Filipe-Santos O,Eberl G,Aebischer T,Späth GF,Bousso P

    更新日期：2012-07-27 00:00:00

  • Fcgamma receptors: old friends and new family members.

    abstract：:Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2005.11.010

    authors： Nimmerjahn F,Ravetch JV

    更新日期：2006-01-01 00:00:00

  • Endocrine Autoimmune Disease as a Fragility of Immune Surveillance against Hypersecreting Mutants.

    abstract：:Some endocrine organs are frequent targets of autoimmune attack. Here, we addressed the origin of autoimmune disease from the viewpoint of feedback control. Endocrine tissues maintain mass through feedback loops that balance cell proliferation and removal according to hormone-driven regulatory signals. We hypothesized...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.04.022

    authors： Korem Kohanim Y,Tendler A,Mayo A,Friedman N,Alon U

    更新日期：2020-05-19 00:00:00

  • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.

    abstract：:Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.12.027

    authors： Laky K,Evans S,Perez-Diez A,Fowlkes BJ

    更新日期：2015-01-20 00:00:00

  • A High-Dimensional Atlas of Human T Cell Diversity Reveals Tissue-Specific Trafficking and Cytokine Signatures.

    abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.07.007

    authors： Wong MT,Ong DE,Lim FS,Teng KW,McGovern N,Narayanan S,Ho WQ,Cerny D,Tan HK,Anicete R,Tan BK,Lim TK,Chan CY,Cheow PC,Lee SY,Takano A,Tan EH,Tam JK,Tan EY,Chan JK,Fink K,Bertoletti A,Ginhoux F,Curotto de Lafail

    更新日期：2016-08-16 00:00:00

  • Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity.

    abstract：:Chronic viral infections remain a global health concern. The early events that facilitate viral persistence have been linked to the activity of the immunoregulatory cytokine IL-10. However, the mechanisms by which IL-10 facilitates the establishment of chronic infection are not fully understood. Herein, we demonstrate...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.01.006

    authors： Smith LK,Boukhaled GM,Condotta SA,Mazouz S,Guthmiller JJ,Vijay R,Butler NS,Bruneau J,Shoukry NH,Krawczyk CM,Richer MJ

    更新日期：2018-02-20 00:00:00

  • Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity.

    abstract：:Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.10.010

    authors： Yatim N,Albert ML

    更新日期：2011-10-28 00:00:00

  • Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

    abstract：:Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.06.011

    authors： Vanden Berghe T,Hulpiau P,Martens L,Vandenbroucke RE,Van Wonterghem E,Perry SW,Bruggeman I,Divert T,Choi SM,Vuylsteke M,Shestopalov VI,Libert C,Vandenabeele P

    更新日期：2015-07-21 00:00:00

  • Regulatory T cells and inflammation: better late than never.

    abstract：:In this issue of Immunity, Curotto de Lafaille et al. (2008) show that adaptive T regulatory cells control airway inflammation and that it is when they are generated that determines whether they function during acute or chronic inflammation. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.07.001

    authors： Ziegler SF

    更新日期：2008-07-18 00:00:00

  • Caspases in Cell Death, Inflammation, and Disease.

    abstract：:Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2019.05.020

    authors： Van Opdenbosch N,Lamkanfi M

    更新日期：2019-06-18 00:00:00

  • Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

    abstract：:Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.11.003

    authors： Simmons A,Gangadharan B,Hodges A,Sharrocks K,Prabhakar S,García A,Dwek R,Zitzmann N,McMichael A

    更新日期：2005-12-01 00:00:00

  • ReaDAPting the Role of PGRP-SD in Bacterial Sensing and Immune Activation.

    abstract：:Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.11.002

    authors： Monahan A,Kleino A,Silverman N

    更新日期：2016-11-15 00:00:00

  • Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84.

    abstract：:CD4(+) T cells deficient in signaling lymphocyte activation molecule (SLAM)-associated protein (SAP) exhibit a selective impairment in adhesion to antigen-presenting B cells but not dendritic cells (DCs), resulting in defective germinal center formation. However, the nature of this selective adhesion defect remained u...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2010.01.010

    authors： Cannons JL,Qi H,Lu KT,Dutta M,Gomez-Rodriguez J,Cheng J,Wakeland EK,Germain RN,Schwartzberg PL

    更新日期：2010-02-26 00:00:00

  • T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response.

    abstract：:Dendritic cell (DC) activation is essential for the induction of immune defense against pathogens, yet needs to be tightly controlled to avoid chronic inflammation and exaggerated immune responses. Here, we identify a mechanism of immune homeostasis by which adaptive immunity, once triggered, tempers DC activation and...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.06.010

    authors： Carrera Silva EA,Chan PY,Joannas L,Errasti AE,Gagliani N,Bosurgi L,Jabbour M,Perry A,Smith-Chakmakova F,Mucida D,Cheroutre H,Burstyn-Cohen T,Leighton JA,Lemke G,Ghosh S,Rothlin CV

    更新日期：2013-07-25 00:00:00

  • The Miami Monkey: A Sunny Alternative to the Berlin Patient.

    abstract：:Curing HIV infection has been impossible, with the exception of the "Berlin Patient." Martinez-Navio et al. (2019) in Miami herein present a rare monkey whose virus was controlled for >3 years after a single genetic intervention that led to persistent production of HIV-neutralizing antibodies in vivo. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.02.010

    authors： Liberatore RA,Ho DD

    更新日期：2019-03-19 00:00:00

  • The specific and essential role of MAVS in antiviral innate immune responses.

    abstract：:The mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFkappaB and IRFs and the induction of interferons in response to viral infection. In vitro studies have also suggested that MAVS is required for interferon induction by cytosolic DNA, but the in vivo evidence is lacking. By generating MAV...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.04.004

    authors： Sun Q,Sun L,Liu HH,Chen X,Seth RB,Forman J,Chen ZJ

    更新日期：2006-05-01 00:00:00

  • Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

    abstract：:Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retent...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00281-9

    authors： Brakebusch C,Fillatreau S,Potocnik AJ,Bungartz G,Wilhelm P,Svensson M,Kearney P,Körner H,Gray D,Fässler R

    更新日期：2002-03-01 00:00:00

  • The quest for CD8+ memory stem cells.

    abstract：:In this issue of Immunity, Turtle et al. (2009) describe the identification of a distinct CD8(+) memory T cell subset in humans, which could bring us closer to the identification of the enigmatic "memory stem cell." ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2009.10.002

    authors： Neuenhahn M,Busch DH

    更新日期：2009-11-20 00:00:00

  • Molecular and Functional Characterization of Lymphoid Progenitor Subsets Reveals a Bipartite Architecture of Human Lymphopoiesis.

    abstract：:The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid progenitors. Here, using a modeling approach in humanized mice, we showed that human lymphoid development stemmed from distinct populations of CD127- and CD127+ early lymp...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.09.009

    authors： Alhaj Hussen K,Vu Manh TP,Guimiot F,Nelson E,Chabaane E,Delord M,Barbier M,Berthault C,Dulphy N,Alberdi AJ,Burlen-Defranoux O,Socié G,Bories JC,Larghero J,Vanneaux V,Verhoeyen E,Wirth T,Dalod M,Gluckman JC,Cumano A

    更新日期：2017-10-17 00:00:00

  • Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection.

    abstract：:Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.12.020

    authors： Blériot C,Dupuis T,Jouvion G,Eberl G,Disson O,Lecuit M

    更新日期：2015-01-20 00:00:00

  • FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

    abstract：:The mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to arise through failure of FAS-mediated removal of self-reactive germinal cen...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.04.010

    authors： Butt D,Chan TD,Bourne K,Hermes JR,Nguyen A,Statham A,O'Reilly LA,Strasser A,Price S,Schofield P,Christ D,Basten A,Ma CS,Tangye SG,Phan TG,Rao VK,Brink R

    更新日期：2015-05-19 00:00:00

  • Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8+ T Cells.

    abstract：:Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.02.012

    authors： Bantug GR,Fischer M,Grählert J,Balmer ML,Unterstab G,Develioglu L,Steiner R,Zhang L,Costa ASH,Gubser PM,Burgener AV,Sauder U,Löliger J,Belle R,Dimeloe S,Lötscher J,Jauch A,Recher M,Hönger G,Hall MN,Romero P,Frez

    更新日期：2018-03-20 00:00:00

  • The bug in MyD88 dependency.

    abstract：:The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2006.09.004

    authors： van Lier RA,Lutter R

    更新日期：2006-10-01 00:00:00

  • Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.

    abstract：:T cell antigen-presenting cell (APC) interactions early during chronic viral infection are crucial for determining viral set point and disease outcome, but how and when different APC subtypes contribute to these outcomes is unclear. The TNF receptor superfamily (TNFRSF) member GITR is important for CD4+ T cell accumul...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.10.014

    authors： Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH

    更新日期：2017-11-21 00:00:00

  • Identity crisis: it's not just Foxp3 anymore.

    abstract：:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.10.012

    authors： Delgoffe GM,Bettini ML,Vignali DA

    更新日期：2012-11-16 00:00:00

  • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.

    abstract：:We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. F...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80645-7

    authors： He YW,Deftos ML,Ojala EW,Bevan MJ

    更新日期：1998-12-01 00:00:00

  • Not All Lymph Nodes Are Created Equal.

    abstract：:Appropriate priming of tolerogenic or effector immune responses is crucial for intestinal homeostasis. Recently in Nature, Esterházy et al. (2019) reveal how compartmentalization of lymphatic drainage to functionally distinct lymph nodes facilitates the simultaneous induction of tolerogenic and effector responses. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.06.018

    authors： Thomson CA,McCoy KD

    更新日期：2019-07-16 00:00:00

  • Impaired activation and localization of LAT in anergic T cells as a consequence of a selective palmitoylation defect.

    abstract：:The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.03.011

    authors： Hundt M,Tabata H,Jeon MS,Hayashi K,Tanaka Y,Krishna R,De Giorgio L,Liu YC,Fukata M,Altman A

    更新日期：2006-05-01 00:00:00

  • Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epithelium.

    abstract：:The thymic medulla provides a specialized microenvironment for the negative selection of T cells, with the presence of autoimmune regulator (Aire)-expressing medullary thymic epithelial cells (mTECs) during the embryonic-neonatal period being both necessary and sufficient to establish long-lasting tolerance. Here we s...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2012.01.016

    authors： Roberts NA,White AJ,Jenkinson WE,Turchinovich G,Nakamura K,Withers DR,McConnell FM,Desanti GE,Benezech C,Parnell SM,Cunningham AF,Paolino M,Penninger JM,Simon AK,Nitta T,Ohigashi I,Takahama Y,Caamano JH,Hayday AC,La

    更新日期：2012-03-23 00:00:00