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Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.

Abstract：

:Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LCs preferentially induced the differentiation of CD4(+) T cells secreting T helper 2 (Th2) cell cytokines and were efficient at priming and crosspriming naive CD8(+) T cells. A third DC population, CD14(-)CD207(-)CD1a(+) DC, which resides in the dermis, could activate CD8(+) T cells better than CD14(+) DCs but less efficiently than LCs. Thus, the human skin displays three DC subsets, two of which, i.e., CD14(+) DCs and LCs, display functional specializations, the preferential activation of humoral and cellular immunity, respectively.

journal_name

Immunity

journal_title

Immunity

authors

Klechevsky E,Morita R,Liu M,Cao Y,Coquery S,Thompson-Snipes L,Briere F,Chaussabel D,Zurawski G,Palucka AK,Reiter Y,Banchereau J,Ueno H

doi

10.1016/j.immuni.2008.07.013

subject

Has Abstract

pub_date

2008-09-19 00:00:00

pages

497-510

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(08)00371-3

journal_volume

29

pub_type

杂志文章

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