Abstract:
:Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base 8-hydroxyguanosine (8-OHG), a marker of oxidative damage in DNA, potentiated cytosolic immune recognition by decreasing its susceptibility to 3' repair exonuclease 1 (TREX1)-mediated degradation. Oxidizative modifications arose physiologically in pathogen DNA during lysosomal reactive oxygen species (ROS) exposure, as well as in neutrophil extracellular trap (NET) DNA during the oxidative burst. 8-OHG was also abundant in UV-exposed skin lesions of LE patients and colocalized with type I interferon (IFN). Injection of oxidized DNA in the skin of lupus-prone mice induced lesions that closely matched respective lesions in patients. Thus, oxidized DNA represents a prototypic damage-associated molecular pattern (DAMP) with important implications for infection, sterile inflammation, and autoimmunity.
journal_name
Immunityjournal_title
Immunityauthors
Gehrke N,Mertens C,Zillinger T,Wenzel J,Bald T,Zahn S,Tüting T,Hartmann G,Barchet Wdoi
10.1016/j.immuni.2013.08.004subject
Has Abstractpub_date
2013-09-19 00:00:00pages
482-95issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(13)00332-4journal_volume
39pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.08.001
更新日期:2008-09-19 00:00:00
abstract::Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.01.006
更新日期:2005-02-01 00:00:00
abstract::The heat shock (HS) response is a universal response activated after exposure to various stimuli. The major HS protein (HSP) is the 72 kDa HSP70 with strong homology in different eukaryotic species. We demonstrate that HS treatment of mice leads to a strong induction of HSP70 in several organs and confers significant ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00310-2
更新日期:2002-05-01 00:00:00
abstract::PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.04.031
更新日期:2018-06-19 00:00:00
abstract::Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.07.007
更新日期:2016-08-16 00:00:00
abstract::The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs....
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.03.012
更新日期:2013-05-23 00:00:00
abstract::Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the targeted gene is flanked...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2015.06.011
更新日期:2015-07-21 00:00:00
abstract::Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.06.025
更新日期:2016-07-19 00:00:00
abstract::Although cellular receptors for immunoglobulins were first identified nearly 40 years ago, their central role in the immune response was discovered only in the last decade. They are key players in both the afferent and efferent phase of an immune response, setting thresholds for B cell activation, regulating the matur...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2005.11.010
更新日期:2006-01-01 00:00:00
abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.011
更新日期:2018-12-18 00:00:00
abstract::The transcription factor Pax5 is a critical regulator of B lymphocyte commitment and identity. In this issue of Immunity, Schebesta et al. (2007) demonstrate how Pax5 activates 170 different genes involved in B cell signaling, adhesion, migration, and maturation. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2007.07.001
更新日期:2007-07-01 00:00:00
abstract::B cell subsets expressing the transcription factor T-bet are associated with humoral immune responses and autoimmunity. Here, we examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet- memory B cells (MBCs) in the context of the influenza-specific immune response. In mi...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.03.020
更新日期:2020-05-19 00:00:00
abstract::The thymus generates major histocompatibility complex (MHC)-restricted alphabetaT cells that only recognize antigenic ligands in association with MHC or MHC-like molecules. We hypothesized that MHC specificity might be imposed on a broader alphabetaTCR repertoire during thymic selection by CD4 and CD8 coreceptors that...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.10.007
更新日期:2007-11-01 00:00:00
abstract::Autophagy constitutes a mechanism for the sequestration and lysosomal degradation of various cytoplasmic structures, including damaged organelles and invading microorganisms. Autophagy not only represents an essential cell-intrinsic mechanism to protect against internal and external stress conditions but also shapes c...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2013.07.017
更新日期:2013-08-22 00:00:00
abstract::Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.020
更新日期:2015-01-20 00:00:00
abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.03.026
更新日期:2011-06-24 00:00:00
abstract::Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2004.07.005
更新日期:2004-08-01 00:00:00
abstract::Inhibition of immune regulatory checkpoints, such as CTLA-4 and the PD-1-PD-L1 axis, is at the forefront of immunotherapy for cancers of various histological types. However, such immunotherapies fail to control neoplasia in a significant proportion of patients. Here, we review how a range of cancer-cell-autonomous cue...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.06.001
更新日期:2016-06-21 00:00:00
abstract::Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.05.018
更新日期:2007-07-01 00:00:00
abstract::Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.08.005
更新日期:2016-08-16 00:00:00
abstract::In T cell-dependent immune responses, high-affinity B cells are selected and differentiate into memory cells; however, the mechanism behind this process remains largely unknown. Here, we report that the selection of high-affinity B cells within germinal centers (GCs) is impaired in Fas-deficient lpr mice in the primar...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00100-5
更新日期:2001-02-01 00:00:00
abstract::Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.12.009
更新日期:2009-01-16 00:00:00
abstract::The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.04.023
更新日期:2020-06-16 00:00:00
abstract::The integrin alpha9beta1 is widely expressed on neutrophils, smooth muscle, hepatocytes, endothelia, and some epithelia. We now show that mice lacking this integrin have a dramatic defect in neutrophil development, with decreased numbers of granulocyte precursors in bone marrow and impaired differentiation of bone mar...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.10.013
更新日期:2006-12-01 00:00:00
abstract::CD4(+)CD25(+) immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function. We analyzed CD4(+)CD25(+) and CD4(+)CD25(-) T cells by DNA microarray, identifying 29 genes differentially expressed in the resting subpopulations, and 77...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00280-7
更新日期:2002-02-01 00:00:00
abstract::The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.06.012
更新日期:2020-07-14 00:00:00
abstract::We have investigated the lymphohematopoietic potentials of endothelial cells (EC) and hematopoietic cells (HPC) sorted from embryos. Expression of VE-cadherin, CD45, and Ter119 was used to distinguish EC (VE-cadherin+CD45-Ter119-) from HPC (VE-cadherin-CD45+). Thus defined, EC population takes up acetylated LDL and co...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80581-6
更新日期:1998-06-01 00:00:00
abstract::Effector T cells are critical for clearance of pathogens from sites of infection. Like cytotoxic CD8(+) T cells, CD4(+) helper T cells have been shown to deliver effector molecules directionally toward the immunological synapse, suggesting that infected cells need to be engaged individually to receive effector signals...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.05.015
更新日期:2012-07-27 00:00:00
abstract::A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80123-5
更新日期:1999-10-01 00:00:00
abstract::The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...
journal_title:Immunity
pub_type: 信件
doi:10.1016/j.immuni.2018.03.005
更新日期:2018-03-20 00:00:00