A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.

Abstract:

:Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local infection with an intracellular pathogen, we have shown that nitric oxide (NO) produced by recruited monocyte-derived cells was essential to limit inflammation and cell recruitment. Mechanistically, we have provided evidence that NO dampened monocyte-derived cell cytokine and chemokine production by inhibiting cellular respiration and reducing cellular ATP:ADP ratio. Such metabolic control operated at the tissue level but only when a sufficient number of NO-producing cells reached the site of infection. Thus, NO production and activity act as a quorum sensing mechanism to help terminate the inflammatory response.

journal_name

Immunity

journal_title

Immunity

authors

Postat J,Olekhnovitch R,Lemaître F,Bousso P

doi

10.1016/j.immuni.2018.07.014

subject

Has Abstract

pub_date

2018-10-16 00:00:00

pages

654-665.e5

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(18)30334-0

journal_volume

49

pub_type

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