当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells.

Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells.

Abstract：

:The interferon-producing plasmacytoid dendritic cells (pDCs) share common progenitors with antigen-presenting classical dendritic cells (cDCs), yet they possess distinct morphology and molecular features resembling those of lymphocytes. It is unclear whether the unique cell fate of pDCs is actively maintained in the steady state. We report that the deletion of transcription factor E2-2 from mature peripheral pDCs caused their spontaneous differentiation into cells with cDC properties. This included the loss of pDC markers, increase in MHC class II expression and T cell priming capacity, acquisition of dendritic morphology, and induction of cDC signature genes. Genome-wide chromatin immunoprecipitation revealed direct binding of E2-2 to key pDC-specific and lymphoid genes, as well as to certain genes enriched in cDCs. Thus, E2-2 actively maintains the cell fate of mature pDCs and opposes the "default" cDC fate, in part through direct regulation of lineage-specific gene expression programs.

journal_name

Immunity

journal_title

Immunity

authors

Ghosh HS,Cisse B,Bunin A,Lewis KL,Reizis B

doi

10.1016/j.immuni.2010.11.023

subject

Has Abstract

pub_date

2010-12-14 00:00:00

pages

905-16

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(10)00453-X

journal_volume

33

pub_type

杂志文章

相关文献

IMMUNITY文献大全
  • Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement.

    abstract：:T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we demonstrate cycling of CTLA-4 between intracellular stores and the ce...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80480-x

    authors： Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS

    更新日期：1996-06-01 00:00:00

  • Instructing B cell fates on the fringe.

    abstract：:The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2009.01.003

    authors： Allman D,Calamito M

    更新日期：2009-02-20 00:00:00

  • Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.

    abstract：:Lentiviral Nef increases T cell signaling activity, but the molecular nature of the stimulus involved is incompletely described. We explored CD4 T cell lipid raft composition in the presence and absence of Nef. Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.11.003

    authors： Simmons A,Gangadharan B,Hodges A,Sharrocks K,Prabhakar S,García A,Dwek R,Zitzmann N,McMichael A

    更新日期：2005-12-01 00:00:00

  • Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions.

    abstract：:Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.11.013

    authors： Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

    更新日期：2007-12-01 00:00:00

  • A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis.

    abstract：:T cell receptor (TCR) transgenic mice specific for hen egg lysozyme (HEL) were crossed with mice expressing HEL on the thyroid epithelium, on pancreatic islet beta cells, or systemically. Depending on the pattern of HEL expression, deletion of double-positive thymocytes ranged from minimal to complete, and peripheral ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80528-2

    authors： Akkaraju S,Ho WY,Leong D,Canaan K,Davis MM,Goodnow CC

    更新日期：1997-08-01 00:00:00

  • Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing.

    abstract：:Efficient unidirectional killing by cytotoxic T lymphocytes (CTL) requires translocation of the microtubule organizing center (MTOC) to the target cell contact site. Here we utilize modulated polarization microscopy and computerized 3D reconstruction of tubulin and LFA-1 immunofluorescence images to investigate how th...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00262-5

    authors： Kuhn JR,Poenie M

    更新日期：2002-01-01 00:00:00

  • Treg cells acquire new directions, cytokines navigate.

    abstract：:Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.09.004

    authors： Ohkura N,Sakaguchi S

    更新日期：2012-09-21 00:00:00

  • Sweet NETs, Bitter Wounds.

    abstract：:What causes slow wound healing rates in diabetes is poorly understood. Wong et al. (2015) report that an increase in the deployment of neutrophil extracellular traps associated with hyperglycemia slows down wound healing. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2015.08.002

    authors： Papayannopoulos V

    更新日期：2015-08-18 00:00:00

  • Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.

    abstract：:We analyzed the participation of a predominant B cell clonotype in the anti-arsonate immune response of mice in which Bcl-2 expression was enforced in B cells. Many of the antibodies expressed by the arsonate-induced memory compartment of these mice were "dual-reactive," displaying increased affinity acquired via V re...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80471-9

    authors： Hande S,Notidis E,Manser T

    更新日期：1998-02-01 00:00:00

  • MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion.

    abstract：:Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.06.016

    authors： Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN

    更新日期：2014-08-21 00:00:00

  • Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation.

    abstract：:Successful organ transplantation requires an optimal innate immune response to avoid tissue injury. In this issue of Immunity, Braza et al. (2018) inhibit pro-inflammatory activation of infiltrating graft macrophages using nanotechnology tools to promote immune tolerance, leading to long-term transplant acceptance in ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2018.11.005

    authors： Pascual-Gil S,Epelman S

    更新日期：2018-11-20 00:00:00

  • Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.

    abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.01.004

    authors： Nguyen HN,Noss EH,Mizoguchi F,Huppertz C,Wei KS,Watts GFM,Brenner MB

    更新日期：2017-02-21 00:00:00

  • Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

    abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.11.010

    authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

    更新日期：2016-12-20 00:00:00

  • Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.

    abstract：:Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LC...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.07.013

    authors： Klechevsky E,Morita R,Liu M,Cao Y,Coquery S,Thompson-Snipes L,Briere F,Chaussabel D,Zurawski G,Palucka AK,Reiter Y,Banchereau J,Ueno H

    更新日期：2008-09-19 00:00:00

  • IL-33 Deals with the Gray Matter.

    abstract：:The central nervous system undergoes extensive postnatal synapse remodeling that is critical for the formation of mature neural circuits. In a recent issue of Science, Vainchtein et al. (2018) describe an additional role for astrocyte-derived interleukin-33 (IL-33) in promoting synapse refinement by microglia in the d...

    journal_title：Immunity

    pub_type： 信件

    doi：10.1016/j.immuni.2018.03.005

    authors： Delmas C,Dalmas E

    更新日期：2018-03-20 00:00:00

  • CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.

    abstract：:A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80123-5

    authors： Shrikant P,Khoruts A,Mescher MF

    更新日期：1999-10-01 00:00:00

  • Deficient T cell fate specification in mice with an induced inactivation of Notch1.

    abstract：:Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre recombinase. Mice with a neonatally induced loss of Notch1 functio...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80054-0

    authors： Radtke F,Wilson A,Stark G,Bauer M,van Meerwijk J,MacDonald HR,Aguet M

    更新日期：1999-05-01 00:00:00

  • A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.

    abstract：:Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.04.024

    authors： Ouchida R,Yamasaki S,Hikida M,Masuda K,Kawamura K,Wada A,Mochizuki S,Tagawa M,Sakamoto A,Hatano M,Tokuhisa T,Koseki H,Saito T,Kurosaki T,Wang JY

    更新日期：2008-07-18 00:00:00

  • The HVEM-BTLA Axis Restrains T Cell Help to Germinal Center B Cells and Functions as a Cell-Extrinsic Suppressor in Lymphomagenesis.

    abstract：:The tumor necrosis factor receptor superfamily member HVEM is one of the most frequently mutated surface proteins in germinal center (GC)-derived B cell lymphomas. We found that HVEM deficiency increased B cell competitiveness during pre-GC and GC responses. The immunoglobulin (Ig) superfamily protein BTLA regulated H...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.05.022

    authors： Mintz MA,Felce JH,Chou MY,Mayya V,Xu Y,Shui JW,An J,Li Z,Marson A,Okada T,Ware CF,Kronenberg M,Dustin ML,Cyster JG

    更新日期：2019-08-20 00:00:00

  • The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.

    abstract：:The peptidoglycan sensor Nod2 and the autophagy protein ATG16L1 have been linked to Crohn's disease (CD). Although Nod2 and the related sensor, Nod1, direct ATG16L1 to initiate anti-bacterial autophagy, whether ATG16L1 affects Nod-driven inflammation has not been examined. Here, we uncover an unanticipated autophagy-i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.10.013

    authors： Sorbara MT,Ellison LK,Ramjeet M,Travassos LH,Jones NL,Girardin SE,Philpott DJ

    更新日期：2013-11-14 00:00:00

  • TIM-1 glycoprotein binds the adhesion receptor P-selectin and mediates T cell trafficking during inflammation and autoimmunity.

    abstract：:Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.03.004

    authors： Angiari S,Donnarumma T,Rossi B,Dusi S,Pietronigro E,Zenaro E,Della Bianca V,Toffali L,Piacentino G,Budui S,Rennert P,Xiao S,Laudanna C,Casasnovas JM,Kuchroo VK,Constantin G

    更新日期：2014-04-17 00:00:00

  • Intracellular NOD-like receptors in host defense and disease.

    abstract：:The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2007.10.002

    authors： Kanneganti TD,Lamkanfi M,Núñez G

    更新日期：2007-10-01 00:00:00

  • Feeling a little SYK after mixing BAFF with BCR.

    abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.03.001

    authors： Infantino S,Tarlinton DM

    更新日期：2013-03-21 00:00:00

  • Inhibition of IFN-gamma signaling by an Epstein-Barr virus immediate-early protein.

    abstract：:Viruses have evolved elaborate mechanisms to target many aspects of the host's immune response. The cytokine IFN-gamma plays a central role in resistance of the host to infection via direct antiviral effects as well as modulation of the immune response. In this study, we demonstrate that the Epstein-Barr virus (EBV) i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00226-6

    authors： Morrison TE,Mauser A,Wong A,Ting JP,Kenney SC

    更新日期：2001-11-01 00:00:00

  • A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells.

    abstract：:Crosspresentation of exogenous antigens (Ags) to CD8(+) T cells by dendritic cells generally requires their entry into the cytosol. Here we show that both soluble and phagocytosed extracellular Ags accessed the cytosol via molecular components required for endoplasmic reticulum (ER)-associated degradation (ERAD). Exog...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.08.017

    authors： Ackerman AL,Giodini A,Cresswell P

    更新日期：2006-10-01 00:00:00

  • PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.

    abstract：:Precise intrathymic cell migration is important for thymocyte maturation and organ architecture. The orchestration of thymocyte trafficking, however, is not well understood at a molecular level. Here, we described highly regulated plexinD1 expression on CD4+CD8+ double positive (DP) thymocytes. PlexinD1 expression was...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.10.008

    authors： Choi YI,Duke-Cohan JS,Ahmed WB,Handley MA,Mann F,Epstein JA,Clayton LK,Reinherz EL

    更新日期：2008-12-19 00:00:00

  • ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation.

    abstract：:T follicular helper (Tfh) cells are essential in the induction of high-affinity, class-switched antibodies. The differentiation of Tfh cells is a multi-step process that depends upon the co-receptor ICOS and the activation of phosphoinositide-3 kinase leading to the expression of key Tfh cell genes. We report that ICO...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.01.017

    authors： Stone EL,Pepper M,Katayama CD,Kerdiles YM,Lai CY,Emslie E,Lin YC,Yang E,Goldrath AW,Li MO,Cantrell DA,Hedrick SM

    更新日期：2015-02-17 00:00:00

  • A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.

    abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00288-1

    authors： Reiser JB,Grégoire C,Darnault C,Mosser T,Guimezanes A,Schmitt-Verhulst AM,Fontecilla-Camps JC,Mazza G,Malissen B,Housset D

    更新日期：2002-03-01 00:00:00

  • The structure of a Bcl-xL/Bim fragment complex: implications for Bim function.

    abstract：:After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00234-6

    authors： Liu X,Dai S,Zhu Y,Marrack P,Kappler JW

    更新日期：2003-09-01 00:00:00

  • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells.

    abstract：:The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, wh...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.12.012

    authors： Miyao T,Floess S,Setoguchi R,Luche H,Fehling HJ,Waldmann H,Huehn J,Hori S

    更新日期：2012-02-24 00:00:00