Abstract:
:Human cytomegalovirus (HCMV) can suppress and evade the immune system. We have identified as a mechanism the ability of HCMV to infect dendritic cells (DC), which initiate the antiviral immune response. HCMV-infected DC show enhanced expression of costimulatory molecules. In contrast, MHC molecules are partially downregulated, leading to a reduced antigen-presenting capacity. Moreover, the apoptosis-inducing ligands CD95L (FasL) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) are upregulated, thereby enabling HCMV-infected DC to delete activated T lymphocytes. This additional layer of viral defense is complemented by nondeletional mechanisms, which suppress surviving T cells. Thus, infection of DC allows the virus to blunt the antiviral T cell response by a multilayered defense strategy and could play a pivotal role in HCMV-triggered immunosuppression.
journal_name
Immunityjournal_title
Immunityauthors
Raftery MJ,Schwab M,Eibert SM,Samstag Y,Walczak H,Schönrich Gdoi
10.1016/s1074-7613(01)00239-4keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
997-1009issue
6eissn
1074-7613issn
1097-4180pii
S1074-7613(01)00239-4journal_volume
15pub_type
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