Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy.

Abstract:

:Human cytomegalovirus (HCMV) can suppress and evade the immune system. We have identified as a mechanism the ability of HCMV to infect dendritic cells (DC), which initiate the antiviral immune response. HCMV-infected DC show enhanced expression of costimulatory molecules. In contrast, MHC molecules are partially downregulated, leading to a reduced antigen-presenting capacity. Moreover, the apoptosis-inducing ligands CD95L (FasL) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) are upregulated, thereby enabling HCMV-infected DC to delete activated T lymphocytes. This additional layer of viral defense is complemented by nondeletional mechanisms, which suppress surviving T cells. Thus, infection of DC allows the virus to blunt the antiviral T cell response by a multilayered defense strategy and could play a pivotal role in HCMV-triggered immunosuppression.

journal_name

Immunity

journal_title

Immunity

authors

Raftery MJ,Schwab M,Eibert SM,Samstag Y,Walczak H,Schönrich G

doi

10.1016/s1074-7613(01)00239-4

keywords:

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

997-1009

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00239-4

journal_volume

15

pub_type

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