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Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

Abstract：

:Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

journal_name

Immunity

journal_title

Immunity

authors

Brakebusch C,Fillatreau S,Potocnik AJ,Bungartz G,Wilhelm P,Svensson M,Kearney P,Körner H,Gray D,Fässler R

doi

10.1016/s1074-7613(02)00281-9

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

465-77

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(02)00281-9

journal_volume

16

pub_type

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