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RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.

Abstract：

:We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. Following hybridoma stimulation, RORgamma t also inhibits IL-2 production but does not affect the induction of Nur-77 and Egr-3 nor the upregulation of CD69. Both the ligand-binding and DNA-binding domains of RORgamma t are required for this effect. We propose that the role of RORgamma t expression in immature thymocytes is to inhibit Fas ligand expression and cytokine secretion following engagement of their TCR during positive or negative selection.

journal_name

Immunity

journal_title

Immunity

authors

He YW,Deftos ML,Ojala EW,Bevan MJ

doi

10.1016/s1074-7613(00)80645-7

subject

Has Abstract

pub_date

1998-12-01 00:00:00

pages

797-806

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80645-7

journal_volume

9

pub_type

杂志文章

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