Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

abstract：:C57BI/6 mice infected with mouse hepatitis virus, strain JHM (MHV-JHM) develop a chronic demyelinating encephalomyelitis. Infectious virus can be isolated only from symptomatic mice. In C57BI/6 mice, two CD8+ T cell epitopes within the MHV-JHM surface glycoprotein were previously identified. Here, we show that mutatio...

journal_title：Immunity

authors： Pewe L,Wu GF,Barnett EM,Castro RF,Perlman S

更新日期：1996-09-01 00:00:00

abstract：:Circulating lymphocytes home to the mucosal lymphoid organs, Peyer's patches (PP), through high endothelial venules (HEV). In situ analyses revealed that transfused lymph node cells (LNCs) interact with PP-HEV in a series of overlapping adhesion events: L-selectin (CD62L) > alpha 4 beta 7 initiates interaction, L-sele...

journal_title：Immunity

authors： Bargatze RF,Jutila MA,Butcher EC

更新日期：1995-07-01 00:00:00

abstract：:Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

journal_title：Immunity

authors： Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

更新日期：2000-02-01 00:00:00

abstract：:NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondep...

journal_title：Immunity

authors： Ogasawara K,Hamerman JA,Ehrlich LR,Bour-Jordan H,Santamaria P,Bluestone JA,Lanier LL

更新日期：2004-06-01 00:00:00

abstract：:Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically engineered mouse model of lung adenocarcinoma and found that Treg cells suppressed ...

journal_title：Immunity

authors： Joshi NS,Akama-Garren EH,Lu Y,Lee DY,Chang GP,Li A,DuPage M,Tammela T,Kerper NR,Farago AF,Robbins R,Crowley DM,Bronson RT,Jacks T

更新日期：2015-09-15 00:00:00

abstract：:For several days after antigenic stimulation, human cytolytic T lymphocyte (CTL) clones exhibit a decrease in their effector activity and in their binding to human leukocyte antigen (HLA)-peptide tetramers. We observed that, when in this state, CTLs lose the colocalization of the T cell receptor (TCR) and CD8. Effecto...

journal_title：Immunity

authors： Demotte N,Stroobant V,Courtoy PJ,Van Der Smissen P,Colau D,Luescher IF,Hivroz C,Nicaise J,Squifflet JL,Mourad M,Godelaine D,Boon T,van der Bruggen P

更新日期：2008-03-01 00:00:00

abstract：:CD4⁺ T cell differentiation is regulated by specialized antigen-presenting cells. Dendritic cells (DCs) produce cytokines that promote naive CD4⁺ T cell differentiation into T helper 1 (Th1), Th17, and inducible T regulatory (iTreg) cells. However, the initiation of Th2 cell responses remains poorly understood, althou...

journal_title：Immunity

authors： Gao Y,Nish SA,Jiang R,Hou L,Licona-Limón P,Weinstein JS,Zhao H,Medzhitov R

更新日期：2013-10-17 00:00:00

abstract：:In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...

journal_title：Immunity

authors： Hogquist KA

更新日期：2006-07-01 00:00:00

abstract：:Depending on the tissue microenvironment, T cells can differentiate into highly diverse subsets expressing unique trafficking receptors and cytokines. Studies of human lymphocytes have primarily focused on a limited number of parameters in blood, representing an incomplete view of the human immune system. Here, we hav...

journal_title：Immunity

authors： Wong MT,Ong DE,Lim FS,Teng KW,McGovern N,Narayanan S,Ho WQ,Cerny D,Tan HK,Anicete R,Tan BK,Lim TK,Chan CY,Cheow PC,Lee SY,Takano A,Tan EH,Tam JK,Tan EY,Chan JK,Fink K,Bertoletti A,Ginhoux F,Curotto de Lafail

更新日期：2016-08-16 00:00:00

abstract：:The presence of CD4+ T cells in the healthy brain parenchyma remains controversial due to the barrier function of the glia limitans. Pasciuto, Burton, Roca et al. in Cell describe the dynamic recruitment of CD4+ T cells within the brain parenchyma, their unexpected contribution to microglial maturation, and, ultimatel...

journal_title：Immunity

authors： Locatelli G,Engelhardt B

更新日期：2020-09-15 00:00:00

abstract：:When type III interferon (IFN-λ; also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially i...

journal_title：Immunity

authors： Lazear HM,Nice TJ,Diamond MS

更新日期：2015-07-21 00:00:00

abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

journal_title：Immunity

authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

更新日期：2017-07-18 00:00:00

abstract：:Monobenzone is a pro-hapten that is exclusively metabolized by melanocytes, thereby haptenizing melanocyte-specific antigens, which results in cytotoxic autoimmunity specifically against pigmented cells. Studying monobenzone in a setting of contact hypersensitivity (CHS), we observed that monobenzone induced a long-la...

journal_title：Immunity

authors： van den Boorn JG,Jakobs C,Hagen C,Renn M,Luiten RM,Melief CJ,Tüting T,Garbi N,Hartmann G,Hornung V

更新日期：2016-06-21 00:00:00

abstract：:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...

journal_title：Immunity

authors： Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RR

更新日期：2003-08-01 00:00:00

abstract：:mel-18 is a mammalian Polycomb group gene encoding a transcriptional repressor with tumor suppressive activity. Overexpression of mel-18 in mice results in cell cycle arrest of B cells upon B cell receptor stimulation with downregulation of c-myc. This phenotype is rescued in mel-18/c-myc double-transgenic mice, sugge...

journal_title：Immunity

authors： Tetsu O,Ishihara H,Kanno R,Kamiyasu M,Inoue H,Tokuhisa T,Taniguchi M,Kanno M

更新日期：1998-10-01 00:00:00

abstract：:Previous in vitro studies defined the minimal regions of RAG1 and RAG2 essential for V(D)J recombination. In order to characterize the role of the C-terminal "dispensable" portion of RAG2, we generated core-RAG2 knock-in mice. We found that the core-RAG2-containing recombinase complex is selectively defective in catal...

journal_title：Immunity

authors： Liang HE,Hsu LY,Cado D,Cowell LG,Kelsoe G,Schlissel MS

更新日期：2002-11-01 00:00:00

abstract：:Commensal microbiota confers a goldilocks state of alertness to pathogens, yet restrains deleterious inflammation. In this issue of Immunity, Geuking et al. (2011) demonstrate that a minimal bacterial community of the Schaedler flora establishes a balance between pro- and anti-inflammatory T cells in the gut. ...

journal_title：Immunity

authors： Rudensky AY,Chervonsky AV

更新日期：2011-05-27 00:00:00

abstract：:T helper 17 (Th17) cells play major roles in autoimmunity and bacterial infections, yet how T cell receptor (TCR) signaling affects Th17 cell differentiation is relatively unknown. We demonstrate that CD4(+) T cells lacking Itk, a tyrosine kinase required for full TCR-induced phospholipase C-gamma (PLC-gamma1) activat...

journal_title：Immunity

authors： Gomez-Rodriguez J,Sahu N,Handon R,Davidson TS,Anderson SM,Kirby MR,August A,Schwartzberg PL

更新日期：2009-10-16 00:00:00

abstract：:ZAP-70 and Syk are PTKs required for TCR and BCR function, respectively. Loss of the Syk PTK results in a nonfunctional BCR. We provide evidence here that ZAP-70 and Syk are functionally homologous in antigen receptor signaling by demonstrating that expression of ZAP-70 in Syk- B cells reconstitutes BCR function. Reco...

journal_title：Immunity

authors： Kong GH,Bu JY,Kurosaki T,Shaw AS,Chan AC

更新日期：1995-05-01 00:00:00

abstract：:The mammalian gut microbiota provides essential metabolites to the host and promotes the differentiation and accumulation of extrathymically generated regulatory T (pTreg) cells. To explore the impact of these cells on intestinal microbial communities, we assessed the composition of the microbiota in pTreg cell-defici...

journal_title：Immunity

authors： Campbell C,Dikiy S,Bhattarai SK,Chinen T,Matheis F,Calafiore M,Hoyos B,Hanash A,Mucida D,Bucci V,Rudensky AY

更新日期：2018-06-19 00:00:00

abstract：:As SARS-CoV-2 infections and death counts continue to rise, it remains unclear why some individuals recover from infection, whereas others rapidly progress and die. Although the immunological mechanisms that underlie different clinical trajectories remain poorly defined, pathogen-specific antibodies often point to imm...

journal_title：Immunity

authors： Atyeo C,Fischinger S,Zohar T,Slein MD,Burke J,Loos C,McCulloch DJ,Newman KL,Wolf C,Yu J,Shuey K,Feldman J,Hauser BM,Caradonna T,Schmidt AG,Suscovich TJ,Linde C,Cai Y,Barouch D,Ryan ET,Charles RC,Lauffenburger D

更新日期：2020-09-15 00:00:00

abstract：:Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 fam...

journal_title：Immunity

authors： Afonina IS,Müller C,Martin SJ,Beyaert R

更新日期：2015-06-16 00:00:00

abstract：:In this issue of Immunity, Pérez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. ...

journal_title：Immunity

authors： Bowie AG

更新日期：2010-09-24 00:00:00

abstract：:Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...

journal_title：Immunity

authors： Woytschak J,Keller N,Krieg C,Impellizzieri D,Thompson RW,Wynn TA,Zinkernagel AS,Boyman O

更新日期：2016-07-19 00:00:00

abstract：:The role of the center of the immunological synapse (the central supramolecular activation cluster or cSMAC) is controversial. One model suggests that the role of the cSMAC depends on antigen quality and can both enhance signaling and receptor downregulation, whereas a second model proposes that the sole function of t...

journal_title：Immunity

authors： Cemerski S,Das J,Giurisato E,Markiewicz MA,Allen PM,Chakraborty AK,Shaw AS

更新日期：2008-09-19 00:00:00

abstract：:Interleukin 9 (IL-9) is a pleiotropic cytokine that can regulate autoimmune responses by enhancing regulatory CD4(+)FoxP3(+) T regulatory (Treg) cell survival and T helper 17 (Th17) cell proliferation. Here, we analyzed the costimulatory requirements for the induction of Th9 cells, and demonstrated that Notch pathway ...

journal_title：Immunity

authors： Elyaman W,Bassil R,Bradshaw EM,Orent W,Lahoud Y,Zhu B,Radtke F,Yagita H,Khoury SJ

更新日期：2012-04-20 00:00:00

abstract：:The molecular basis of T cell anergy is not completely understood. We show that in antigen-primed anergic murine CD4(+) T cells the linker for activation of T cells (LAT) is hypophosphorylated upon CD3/CD28 restimulation. Signaling events downstream of LAT (PLCgamma1 phosphorylation and p85 [PI3-K] association) were i...

journal_title：Immunity

authors： Hundt M,Tabata H,Jeon MS,Hayashi K,Tanaka Y,Krishna R,De Giorgio L,Liu YC,Fukata M,Altman A

更新日期：2006-05-01 00:00:00

abstract：:Radiotherapy induces DNA damage and cell death, but recent data suggest that concomitant immune stimulation is an integral part of the therapeutic action of ionizing radiation. It is poorly understood how radiotherapy supports tumor-specific immunity. Here we report that radiotherapy induced tumor cell death and trans...

journal_title：Immunity

authors： Surace L,Lysenko V,Fontana AO,Cecconi V,Janssen H,Bicvic A,Okoniewski M,Pruschy M,Dummer R,Neefjes J,Knuth A,Gupta A,van den Broek M

更新日期：2015-04-21 00:00:00

abstract：:Dendritic cell (DC) activation is essential for the induction of immune defense against pathogens, yet needs to be tightly controlled to avoid chronic inflammation and exaggerated immune responses. Here, we identify a mechanism of immune homeostasis by which adaptive immunity, once triggered, tempers DC activation and...

journal_title：Immunity

authors： Carrera Silva EA,Chan PY,Joannas L,Errasti AE,Gagliani N,Bosurgi L,Jabbour M,Perry A,Smith-Chakmakova F,Mucida D,Cheroutre H,Burstyn-Cohen T,Leighton JA,Lemke G,Ghosh S,Rothlin CV

更新日期：2013-07-25 00:00:00

abstract：:The humoral immune response to protein antigens is composed of a rapid low-affinity IgM antibody response followed by an IgG response exhibiting higher affinity. Here, we demonstrate that Lsc, a protein that regulates G protein-coupled-receptor signaling and RhoA activation, is required by B lymphocytes for the antige...

journal_title：Immunity

authors： Rubtsov A,Strauch P,Digiacomo A,Hu J,Pelanda R,Torres RM

更新日期：2005-11-01 00:00:00