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NKG2D blockade prevents autoimmune diabetes in NOD mice.

Abstract：

:NKG2D is an activating receptor on CD8(+) T cells and NK cells that has been implicated in immunity against tumors and microbial pathogens. Here we show that RAE-1 is present in prediabetic pancreas islets of NOD mice and that autoreactive CD8(+) T cells infiltrating the pancreas express NKG2D. Treatment with a nondepleting anti-NKG2D monoclonal antibody (mAb) during the prediabetic stage completely prevented disease by impairing the expansion and function of autoreactive CD8(+) T cells. These findings demonstrate that NKG2D is essential for disease progression and suggest a new therapeutic target for autoimmune type I diabetes.

journal_name

Immunity

journal_title

Immunity

authors

Ogasawara K,Hamerman JA,Ehrlich LR,Bour-Jordan H,Santamaria P,Bluestone JA,Lanier LL

doi

10.1016/j.immuni.2004.05.008

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

757-67

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(04)00140-2

journal_volume

20

pub_type

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