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Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.

Abstract：

:The immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted to preferentially give rise to CD8alphaalpha(+)TCRalphabeta(+) IELs, but they required exposure to self-agonist peptides. The agonist-selected TCRalphabeta(+) thymocytes are CD4 and CD8 double-negative, and their final maturation, including the induction of CD8alphaalpha expression, appeared to occur only after thymus export in the IL-15-rich environment of the gut. These developmental steps, including precommitment of immature thymocytes, TCR-mediated agonist selection, and postthymic differentiation promoted by cytokines, define a unique pathway for the generation of CD8alphaalpha(+)TCRalphabeta(+) IEL.

journal_name

Immunity

journal_title

Immunity

authors

Gangadharan D,Lambolez F,Attinger A,Wang-Zhu Y,Sullivan BA,Cheroutre H

doi

10.1016/j.immuni.2006.08.018

subject

Has Abstract

pub_date

2006-10-01 00:00:00

pages

631-41

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(06)00429-8

journal_volume

25

pub_type

杂志文章

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