Abstract:
:TCR transgenic mice that express a peptide antigen in keratinocytes develop a lethal CD8 T cell-dependent autoimmune disease. We employed an adoptive transfer system to understand this disease and show that transfer of low numbers of naive CD8 T cells into peptide transgenic mice caused chronic skin disease. The antigen-presenting cell that initiated this response was the epidermal Langerhans cell. Naive CD8 T cells proliferated extensively, migrated to tissues, developed effector function, and were capable of making a recall response. These features are very different from the abortive activation of CD8 T cells that occurred in response to the same antigen presented by APC from other tissues. Furthermore, tolerance was dominant when the antigen was presented by both Langerhans cells and other APC. These data suggest that Langerhans cells do not have tolerogenic properties in the steady state.
journal_name
Immunityjournal_title
Immunityauthors
Mayerova D,Parke EA,Bursch LS,Odumade OA,Hogquist KAdoi
10.1016/j.immuni.2004.07.019keywords:
subject
Has Abstractpub_date
2004-09-01 00:00:00pages
391-400issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(04)00215-8journal_volume
21pub_type
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