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Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.

Abstract：

:T cell activation induces functional changes in cell shape and cytoskeletal architecture. To facilitate the collection of dynamic, high-resolution images of activated T cells, we plated T cells on coverslips coated with antibodies to the T cell receptor (TCR). Using these images, we were able to quantitate the morphological responses of individual cells over time. Here, we show that TCR engagement triggers the formation and expansion of contacts bounded by continuously remodeled actin-rich rings. These processes are associated with the extension of lamellipodia and require actin polymerization, tyrosine kinase activation, cytoplasmic calcium increases, and LAT, an important hematopoietic adaptor. In addition, the maintenance of the resulting contact requires sustained calcium influxes, an intact microtubule cytoskeleton, and functional LAT.

journal_name

Immunity

journal_title

Immunity

authors

Bunnell SC,Kapoor V,Trible RP,Zhang W,Samelson LE

doi

10.1016/s1074-7613(01)00112-1

keywords:

subject

Has Abstract

pub_date

2001-03-01 00:00:00

pages

315-29

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(01)00112-1

journal_volume

14

pub_type

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