Targeting Immune Cell Wiring in Ulcerative Colitis.

Abstract:

:The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. Two clinical trials published in The New England Journal of Medicine now challenge this paradigm and suggest new avenues for research.

journal_name

Immunity

journal_title

Immunity

authors

Neurath MF,Chiriac MT

doi

10.1016/j.immuni.2019.10.011

subject

Has Abstract

pub_date

2019-11-19 00:00:00

pages

791-793

issue

5

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(19)30455-8

journal_volume

51

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Interleukin-23 drives intestinal inflammation through direct activity on T cells.

    abstract::Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, w...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.08.010

    authors: Ahern PP,Schiering C,Buonocore S,McGeachy MJ,Cua DJ,Maloy KJ,Powrie F

    更新日期:2010-08-27 00:00:00

  • Ending Ebola.

    abstract::Promising vaccines and results from recent clinical trials of therapeutic antibodies against Ebola virus offer hope for an end to this devastating disease. We asked three investigators in the field to share their views on the remaining challenges and important future research directions as we work toward controlling E...

    journal_title:Immunity

    pub_type: 社论

    doi:10.1016/j.immuni.2019.11.010

    authors:

    更新日期:2019-12-17 00:00:00

  • Caspase-1 activation of IL-1beta and IL-18 are essential for Shigella flexneri-induced inflammation.

    abstract::Caspases are intracellular proteases that mediate mammalian cell apoptosis. Caspase-1 (Casp-1) is a unique caspase because it activates the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Shigella flexneri, the etiological agent of bacillary dysentery, induces macrophage apoptosis, which requires Casp-1 an...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80209-5

    authors: Sansonetti PJ,Phalipon A,Arondel J,Thirumalai K,Banerjee S,Akira S,Takeda K,Zychlinsky A

    更新日期:2000-05-01 00:00:00

  • Toll-like receptor 9, what o'clock is it?

    abstract::In this issue of Immunity, Silver et al. (2012) provide evidence that murine Toll-like receptor 9 (TLR9) expression and function in innate and adaptive immunity is controlled by the circadian cycle. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2012.02.003

    authors: Obermann HL,Bauer S

    更新日期:2012-02-24 00:00:00

  • NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

    abstract::The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2011.03.026

    authors: Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

    更新日期:2011-06-24 00:00:00

  • Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing.

    abstract::We have generated a site-directed transgenic (sd-tg) mouse model in which the JH locus has been replaced with a rearranged VDJ coding for the heavy chain of an anti-DNA antibody. In these mice, B cells expressing the anti-dsDNA specificity are negatively regulated. We observe a novel mechanism for B cell tolerance, re...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90064-0

    authors: Chen C,Nagy Z,Prak EL,Weigert M

    更新日期:1995-12-01 00:00:00

  • T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate.

    abstract::Higher- or lower-affinity germinal center (GC) B cells are directed either to plasma cell or GC recycling, respectively; however, how commitment to the plasma cell fate takes place is unclear. We found that a population of light zone (LZ) GC cells, Bcl6loCD69hi expressing a transcription factor IRF4 and higher-affinit...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.03.027

    authors: Ise W,Fujii K,Shiroguchi K,Ito A,Kometani K,Takeda K,Kawakami E,Yamashita K,Suzuki K,Okada T,Kurosaki T

    更新日期:2018-04-17 00:00:00

  • Bruton's tyrosine kinase and phospholipase Cgamma2 mediate chemokine-controlled B cell migration and homing.

    abstract::Control of integrin-mediated adhesion and migration by chemokines plays a critical role in B cell development, differentiation, and function; however, the underlying signaling mechanisms are poorly defined. Here we show that the chemokine SDF-1 induced activation of Bruton's tyrosine kinase (Btk) and that integrin-med...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2006.11.012

    authors: de Gorter DJ,Beuling EA,Kersseboom R,Middendorp S,van Gils JM,Hendriks RW,Pals ST,Spaargaren M

    更新日期:2007-01-01 00:00:00

  • CD40, but not CD40L, is required for the optimal priming of T cells and control of aerosol M. tuberculosis infection.

    abstract::CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T cell responses. In contrast, CD40L(-/-) mice were resistant to M. tuberculosis. This asymmetry in outcome of infection between the two knockout strains is likely due ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(03)00324-8

    authors: Lazarevic V,Myers AJ,Scanga CA,Flynn JL

    更新日期:2003-12-01 00:00:00

  • What doesn't kill you makes you stronger: the anti-inflammatory effect of neutrophil respiratory burst.

    abstract::In this issue of Immunity, Campbell et al. (2014) demonstrate that hypoxia caused by the respiratory burst of infiltrating neutrophils activates hypoxia inducible factor (HIF) in epithelial cells and protects the mucosa cells in an experimental model of inflammatory bowel disease. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2013.12.003

    authors: Borregaard N

    更新日期:2014-01-16 00:00:00

  • The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.

    abstract::The role of the center of the immunological synapse (the central supramolecular activation cluster or cSMAC) is controversial. One model suggests that the role of the cSMAC depends on antigen quality and can both enhance signaling and receptor downregulation, whereas a second model proposes that the sole function of t...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.06.014

    authors: Cemerski S,Das J,Giurisato E,Markiewicz MA,Allen PM,Chakraborty AK,Shaw AS

    更新日期:2008-09-19 00:00:00

  • Interleukin-22-producing natural killer cells and lymphoid tissue inducer-like cells in mucosal immunity.

    abstract::Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell subset that specializes in production of interleukin (IL)-22. This cytokine pl...

    journal_title:Immunity

    pub_type: 杂志文章,评审

    doi:10.1016/j.immuni.2009.06.008

    authors: Colonna M

    更新日期:2009-07-17 00:00:00

  • CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity.

    abstract::Memory B cells (MBCs) and plasma cells (PCs) constitute the two cellular outputs of germinal center (GC) responses that together facilitate long-term humoral immunity. Although expression of the transcription factor BLIMP-1 identifies cells undergoing PC differentiation, no such marker exists for cells committed to th...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2017.11.022

    authors: Suan D,Kräutler NJ,Maag JLV,Butt D,Bourne K,Hermes JR,Avery DT,Young C,Statham A,Elliott M,Dinger ME,Basten A,Tangye SG,Brink R

    更新日期:2017-12-19 00:00:00

  • Illuminating the black box of TNF action in tuberculous granulomas.

    abstract::TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2008.07.003

    authors: Miller EA,Ernst JD

    更新日期:2008-08-15 00:00:00

  • The bug in MyD88 dependency.

    abstract::The contribution of MyD88 adaptor-mediated signaling in immune responses to fungi is largely unexplored. In this issue of Immunity, show that MyD88 is dispensable in several aspects of dendritic-cell trafficking and T cell differentiation in response to a respiratory fungus. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2006.09.004

    authors: van Lier RA,Lutter R

    更新日期:2006-10-01 00:00:00

  • A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses.

    abstract::Recruitment of immune cells with antimicrobial activities is essential to fight local infections but has the potential to trigger immunopathology. Whether the immune system has the ability to sense inflammation intensity and self-adjust accordingly to limit tissue damage remains to be fully established. During local i...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2018.07.014

    authors: Postat J,Olekhnovitch R,Lemaître F,Bousso P

    更新日期:2018-10-16 00:00:00

  • Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.

    abstract::To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(02)00480-6

    authors: Spiotto MT,Yu P,Rowley DA,Nishimura MI,Meredith SC,Gajewski TF,Fu YX,Schreiber H

    更新日期:2002-12-01 00:00:00

  • T cell receptor delta gene rearrangement and T early alpha (TEA) expression in immature alpha beta lineage thymocytes: implications for alpha beta/gamma delta lineage commitment.

    abstract::Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80296-4

    authors: Wilson A,de Villartay JP,MacDonald HR

    更新日期:1996-01-01 00:00:00

  • Notch signaling regulates antigen sensitivity of naive CD4+ T cells by tuning co-stimulation.

    abstract::Adaptive immune responses begin when naive CD4(+) T cells engage peptide+major histocompatibility complex class II and co-stimulatory molecules on antigen-presenting cells (APCs). Notch signaling can influence effector functions in differentiated CD4(+) T helper and T regulatory cells. Whether and how ligand-induced N...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2014.12.027

    authors: Laky K,Evans S,Perez-Diez A,Fowlkes BJ

    更新日期:2015-01-20 00:00:00

  • Caspase-8: clipping off RIG-I signaling.

    abstract::Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2011.03.011

    authors: Roth S,Ruland J

    更新日期:2011-03-25 00:00:00

  • Dendritic cells in vivo: a key target for a new vaccine science.

    abstract::Dendritic cells (DCs) are the antigen presenting cells that initiate and regulate immunity. By studying these cells in vivo, we will be able to move beyond standard approaches and design vaccines that directly harness the elaborate properties of DCs to control immunity. ...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2008.08.001

    authors: Steinman RM

    更新日期:2008-09-19 00:00:00

  • Integrating genomic signatures for immunologic discovery.

    abstract::Understanding heterogeneity in adaptive immune responses is essential to dissect pathways of memory B and T cell differentiation and to define correlates of protective immunity. Traditionally, immunologists have deconvoluted this heterogeneity with flow cytometry--with combinations of markers to define signatures that...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.02.001

    authors: Haining WN,Wherry EJ

    更新日期:2010-02-26 00:00:00

  • "Nuts and bolts" of disease tolerance.

    abstract::Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice. ...

    journal_title:Immunity

    pub_type: 评论,杂志文章

    doi:10.1016/j.immuni.2014.07.011

    authors: Soares MP

    更新日期:2014-08-21 00:00:00

  • CTLA-4 blockade reverses CD8+ T cell tolerance to tumor by a CD4+ T cell- and IL-2-dependent mechanism.

    abstract::A tumor-specific CD8+ T cell response was studied using adoptive transfer of OT-I TCR transgenic cells. Upon i.p. challenge with E.G7 tumor, OT-I cells undergo CD4+ T cell-independent expansion at the tumor site and develop lytic function. Before tumor elimination, however, they leave the peritoneal cavity (PC) and ap...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/s1074-7613(00)80123-5

    authors: Shrikant P,Khoruts A,Mescher MF

    更新日期:1999-10-01 00:00:00

  • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development.

    abstract::The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establis...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.09.010

    authors: Ohkura N,Hamaguchi M,Morikawa H,Sugimura K,Tanaka A,Ito Y,Osaki M,Tanaka Y,Yamashita R,Nakano N,Huehn J,Fehling HJ,Sparwasser T,Nakai K,Sakaguchi S

    更新日期:2012-11-16 00:00:00

  • Macrophage Epithelial Reprogramming Underlies Mycobacterial Granuloma Formation and Promotes Infection.

    abstract::Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2016.09.014

    authors: Cronan MR,Beerman RW,Rosenberg AF,Saelens JW,Johnson MG,Oehlers SH,Sisk DM,Jurcic Smith KL,Medvitz NA,Miller SE,Trinh LA,Fraser SE,Madden JF,Turner J,Stout JE,Lee S,Tobin DM

    更新日期:2016-10-18 00:00:00

  • Asymmetric processing of coding ends and the effect of coding end nucleotide composition on V(D)J recombination.

    abstract::The products of V(D)J recombination are coding and signal joints. We show that the nucleotide composition of the coding ends affects V(D)J recombination. The presence of Ts at the 5' end of either the 12 mer or the 23 mer recombination signal sequence (RSS) greatly decreases coding and signal joint formation, and Ts a...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/1074-7613(95)90146-9

    authors: Ezekiel UR,Engler P,Stern D,Storb U

    更新日期:1995-04-01 00:00:00

  • Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.

    abstract::Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2017.04.018

    authors: Mildner A,Schönheit J,Giladi A,David E,Lara-Astiaso D,Lorenzo-Vivas E,Paul F,Chappell-Maor L,Priller J,Leutz A,Amit I,Jung S

    更新日期:2017-05-16 00:00:00

  • The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.

    abstract::T cell activation is tightly regulated to avoid autoimmunity. Gene related to anergy in lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell tolerance. Here, we generated and analyzed GRAIL-deficient mice and found they were resistant to immune tolerance induction and exhibited great...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2010.05.002

    authors: Nurieva RI,Zheng S,Jin W,Chung Y,Zhang Y,Martinez GJ,Reynolds JM,Wang SL,Lin X,Sun SC,Lozano G,Dong C

    更新日期:2010-05-28 00:00:00

  • Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

    abstract::Secondary diversification of the B cell repertoire by immunoglobulin gene somatic hypermutation in the germinal center (GC) is essential for providing the high-affinity antibody specificities required for long-term humoral immunity. While the risk to self-tolerance posed by inadvertent generation of self-reactive GC B...

    journal_title:Immunity

    pub_type: 杂志文章

    doi:10.1016/j.immuni.2012.07.017

    authors: Chan TD,Wood K,Hermes JR,Butt D,Jolly CJ,Basten A,Brink R

    更新日期:2012-11-16 00:00:00