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Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease.

Abstract：

:Expression of B cell-activating factor (BAFF), a critical B cell survival factor, is elevated in autoimmune and lymphoproliferative disorders. Mice overproducing BAFF develop systemic lupus erythematosus (SLE)-like disease and exhibit B cell activation of classical and alternative NF-kappaB-signaling pathways. We used a genetic approach and found that both NF-kappaB-signaling pathways contributed to disease development but act through distinct mechanisms. Whereas BAFF enhanced long-term B cell survival primarily through the alternative, but not the classical, NF-kappaB pathway, it promoted immunoglobulin class switching and generation of pathogenic antibodies through the classical pathway. Activation of the alternative NF-kappaB pathway resulted in integrin upregulation, thereby retaining autoreactive B cells in the splenic marginal zone, a compartment that contributes to their survival. Thus, both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction. The same mechanisms may be involved in the pathogenesis of human SLE.

journal_name

Immunity

journal_title

Immunity

authors

Enzler T,Bonizzi G,Silverman GJ,Otero DC,Widhopf GF,Anzelon-Mills A,Rickert RC,Karin M

doi

10.1016/j.immuni.2006.07.010

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

403-15

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(06)00386-4

journal_volume

25

pub_type

杂志文章

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