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Germinal Center B Cell Dynamics.

Abstract：

:Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.

journal_name

Immunity

journal_title

Immunity

authors

Mesin L,Ersching J,Victora GD

doi

10.1016/j.immuni.2016.09.001

subject

Has Abstract

pub_date

2016-09-20 00:00:00

pages

471-482

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(16)30345-4

journal_volume

45

pub_type

杂志文章,评审

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