"Dangerous crystals".

abstract：:Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and e...

journal_title：Immunity

authors： Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,D

更新日期：2017-11-21 00:00:00

abstract：:Combination antiretroviral therapy for HIV infection improves immune function and eliminates the risk of AIDS-related complications but does not restore full health. HIV-infected adults have excess risk of cardiovascular, liver, kidney, bone, and neurologic diseases. Many markers of inflammation are elevated in HIV di...

journal_title：Immunity

authors： Deeks SG,Tracy R,Douek DC

更新日期：2013-10-17 00:00:00

abstract：:In this issue of Immunity, it is found that the downregulation of Pax-5 during antigen-dependent-terminal differentiation results in a substantial loss of B cell identity and the transition to a plasma cell state. ...

journal_title：Immunity

authors： Singh H,Sciammas R

更新日期：2006-03-01 00:00:00

abstract：:Conserved molecular patterns derived from pathogenic microorganisms prime antigen-presenting dendritic cells (DC) to induce adaptive T cell responses. In contrast, virus-infected or tumor cells that express low levels of major histocompatibility complex (MHC) class I activate natural killer (NK) cells for direct killi...

journal_title：Immunity

authors： Mocikat R,Braumüller H,Gumy A,Egeter O,Ziegler H,Reusch U,Bubeck A,Louis J,Mailhammer R,Riethmüller G,Koszinowski U,Röcken M

更新日期：2003-10-01 00:00:00

abstract：:During signal transduction through the B cell antigen receptor (BCR), several signaling elements are brought together by the adaptor protein SLP-65. We have investigated the role of SLP-65 in B cell maturation and function in mice deficient for SLP-65. While the mice are viable, B cell development is affected at sever...

journal_title：Immunity

authors： Jumaa H,Wollscheid B,Mitterer M,Wienands J,Reth M,Nielsen PJ

更新日期：1999-11-01 00:00:00

abstract：:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c ad...

journal_title：Immunity

authors： Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

更新日期：1998-06-01 00:00:00

abstract：:Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated through dephosphorylation at Ser3. Activated cofilin enables actin dynamics through severing and depolymerization of F-actin. Binding of cofilin to actin is req...

journal_title：Immunity

authors： Klemke M,Wabnitz GH,Funke F,Funk B,Kirchgessner H,Samstag Y

更新日期：2008-09-19 00:00:00

abstract：:Adjuvants enhance immunity to vaccines and experimental antigens by a variety of mechanisms. In the past decade, many receptors and signaling pathways in the innate immune system have been defined and these innate responses strongly influence the adaptive immune response. The focus of this review is to delineate the i...

journal_title：Immunity

authors： Coffman RL,Sher A,Seder RA

更新日期：2010-10-29 00:00:00

abstract：:A major mechanism maintaining immune tolerance is the deletion of potentially autoreactive thymocytes by apoptosis during development in the thymus. Previous reports suggest that apoptosis is induced by high avidity signals transduced via the T cell receptor; however, the role of signals transduced by other cell surfa...

journal_title：Immunity

authors： Castro JE,Listman JA,Jacobson BA,Wang Y,Lopez PA,Ju S,Finn PW,Perkins DL

更新日期：1996-12-01 00:00:00

abstract：:Previously, we described AGM-derived endothelial cell lines that either inhibited or permitted the development of erythroid or B cells. We utilized a differential gene expression method to isolate a chemokine, termed WECHE, from one of these cell lines. WECHE inhibited the formation of erythroid cells but had no effec...

journal_title：Immunity

authors： Ohneda O,Ohneda K,Nomiyama H,Zheng Z,Gold SA,Arai F,Miyamoto T,Taillon BE,McIndoe RA,Shimkets RA,Lewin DA,Suda T,Lasky LA

更新日期：2000-02-01 00:00:00

abstract：:CD4(+) T cells differentiate into phenotypically distinct T helper cells upon antigenic stimulation. Regulation of plasticity between these CD4(+) T-cell lineages is critical for immune homeostasis and prevention of autoimmune disease. However, the factors that regulate lineage stability are largely unknown. Here we i...

journal_title：Immunity

authors： Brown CC,Esterhazy D,Sarde A,London M,Pullabhatla V,Osma-Garcia I,Al-Bader R,Ortiz C,Elgueta R,Arno M,de Rinaldis E,Mucida D,Lord GM,Noelle RJ

更新日期：2015-03-17 00:00:00

abstract：:Vgamma9Vdelta2 T lymphocytes, a major gammadelta T lymphocyte subset in humans, display cytolytic activity against various tumor cells upon recognition of yet uncharacterized structures. Here, we show that an entity related to the mitochondrial F1-ATPase is expressed on tumor cell surface and promotes tumor recognitio...

journal_title：Immunity

authors： Scotet E,Martinez LO,Grant E,Barbaras R,Jenö P,Guiraud M,Monsarrat B,Saulquin X,Maillet S,Estève JP,Lopez F,Perret B,Collet X,Bonneville M,Champagne E

更新日期：2005-01-01 00:00:00

abstract：:In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...

journal_title：Immunity

authors： Hogquist KA

更新日期：2006-07-01 00:00:00

abstract：:In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...

journal_title：Immunity

authors： McKee AS,Munks MW,Marrack P

更新日期：2007-11-01 00:00:00

abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

journal_title：Immunity

authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

更新日期：2003-05-01 00:00:00

abstract：:In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...

journal_title：Immunity

authors： Greene TT,Labarta-Bajo L,Zuñiga EI

更新日期：2018-08-21 00:00:00

abstract：:PKCβ-null (Prkcb-/-) mice are severely immunodeficient. Here we show that mice whose B cells lack PKCβ failed to form germinal centers and plasma cells, which undermined affinity maturation and antibody production in response to immunization. Moreover, these mice failed to develop plasma cells in response to viral inf...

journal_title：Immunity

authors： Tsui C,Martinez-Martin N,Gaya M,Maldonado P,Llorian M,Legrave NM,Rossi M,MacRae JI,Cameron AJ,Parker PJ,Leitges M,Bruckbauer A,Batista FD

更新日期：2018-06-19 00:00:00

abstract：:After acute inflammation or infection, tissue-resident macrophages are replaced by inflammatory DCs and effector macrophages that arise from circulating monocytes. In this issue of Immunity, Goldszmid et al. (2012) demonstrate a central role for NK cell-derived IFN-γ in signaling and facilitating this transition. ...

journal_title：Immunity

authors： Yap GS,Rivera A

更新日期：2012-06-29 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been det...

journal_title：Immunity

authors： Han JH,Akira S,Calame K,Beutler B,Selsing E,Imanishi-Kari T

更新日期：2007-07-01 00:00:00

abstract：:T cell receptor (TCR)-mediated cytoskeletal reorganization is considered to be actin-related protein (Arp) 2/3 complex dependent. We therefore examined the requirement for Arp2/3- and formin-dependent F-actin nucleation during T cell activation. We demonstrated that without Arp2/3-mediated actin nucleation, stimulated...

journal_title：Immunity

authors： Gomez TS,Kumar K,Medeiros RB,Shimizu Y,Leibson PJ,Billadeau DD

更新日期：2007-02-01 00:00:00

abstract：:Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LC...

journal_title：Immunity

authors： Klechevsky E,Morita R,Liu M,Cao Y,Coquery S,Thompson-Snipes L,Briere F,Chaussabel D,Zurawski G,Palucka AK,Reiter Y,Banchereau J,Ueno H

更新日期：2008-09-19 00:00:00

abstract：:Sterile inflammation can be initiated by innate immune recognition of markers of tissue injury termed damage-associated molecular patterns (DAMPs). DAMP recognition by dendritic cells (DCs) has also been postulated to lead to T cell responses to foreign antigens in tumors or allografts. Many DAMPs represent intracellu...

journal_title：Immunity

authors： Ahrens S,Zelenay S,Sancho D,Hanč P,Kjær S,Feest C,Fletcher G,Durkin C,Postigo A,Skehel M,Batista F,Thompson B,Way M,Reis e Sousa C,Schulz O

更新日期：2012-04-20 00:00:00

abstract：:Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...

journal_title：Immunity

authors： Strober W

更新日期：2010-11-24 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...

journal_title：Immunity

authors： Oliphant CJ,Hwang YY,Walker JA,Salimi M,Wong SH,Brewer JM,Englezakis A,Barlow JL,Hams E,Scanlon ST,Ogg GS,Fallon PG,McKenzie AN

更新日期：2014-08-21 00:00:00

abstract：:An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed I...

journal_title：Immunity

authors： Pflanz S,Timans JC,Cheung J,Rosales R,Kanzler H,Gilbert J,Hibbert L,Churakova T,Travis M,Vaisberg E,Blumenschein WM,Mattson JD,Wagner JL,To W,Zurawski S,McClanahan TK,Gorman DM,Bazan JF,de Waal Malefyt R,Rennick D,

更新日期：2002-06-01 00:00:00

abstract：:Null mutations that cripple T cell receptor (TCR) signaling explain rare primary immunodeficiencies, but it is not understood why more common polymorphisms that lead to subtle TCR signaling defects are paradoxically associated with autoimmunity. Here we analyzed how a series of Zap70 variants with step-wise decreases ...

journal_title：Immunity

authors： Siggs OM,Miosge LA,Yates AL,Kucharska EM,Sheahan D,Brdicka T,Weiss A,Liston A,Goodnow CC

更新日期：2007-12-01 00:00:00

abstract：:Whereas dendritic cells (DCs) can be activated in many ways to trigger immunity, hardly anything is known about the mechanisms that counterbalance DC activation. Cyster and colleagues now demonstrate that the "self" molecule CD47 on erythrocytes critically restricts splenic DC activation. ...

journal_title：Immunity

authors： van den Berg TK,van Bruggen R

更新日期：2015-10-20 00:00:00

abstract：:Phenotypic plasticity of T helper 17 (Th17) cells suggests instability of chromatin structure of key genes of this lineage. We identified epigenetic modifications across the clustered Il17a and Il17f and the Ifng loci before and after differential IL-12 or TGF-beta cytokine signaling, which induce divergent fates of T...

journal_title：Immunity

authors： Mukasa R,Balasubramani A,Lee YK,Whitley SK,Weaver BT,Shibata Y,Crawford GE,Hatton RD,Weaver CT

更新日期：2010-05-28 00:00:00

abstract：:We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, sup...

journal_title：Immunity

authors： Veldhoen M,Hocking RJ,Atkins CJ,Locksley RM,Stockinger B

更新日期：2006-02-01 00:00:00

abstract：:The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...

journal_title：Immunity

authors： Sun M,Kee BL

更新日期：2017-09-19 00:00:00