Abstract:
:Activation-induced cytidine deaminase (AID) is required for immunoglobulin (Ig) gene class switch recombination (CSR), somatic hypermutation (SHM), and somatic hyperconversion. In general, high AID expression is found in mature B cells that are responding to antigens. However, AID expression and SHM have also been detected in developing B cells from transgenic mice that have a limited Ig repertoire. Here we demonstrate that AID expression, ongoing CSR, and active SHM occur in developing B cells from wild-type mice. Further, our results suggest that somatic variants arising from developing B cells in the bone marrow further diversify in the spleen of unimmunized mice. AID expression in developing B cells is T cell independent but involves engagement of B cell receptors and Toll-like receptors. Early AID expression can increase the preimmune repertoire of developing B cells, may provide an innate population of IgG- and IgA-expressing cells, and could be involved in receptor editing of self-reactive immature B cells.
journal_name
Immunityjournal_title
Immunityauthors
Han JH,Akira S,Calame K,Beutler B,Selsing E,Imanishi-Kari Tdoi
10.1016/j.immuni.2007.05.018subject
Has Abstractpub_date
2007-07-01 00:00:00pages
64-75issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(07)00330-5journal_volume
27pub_type
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