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Induction of rapid T cell activation and tolerance by systemic presentation of an orally administered antigen.

Abstract：

:To understand how orally introduced antigen regulates peripheral immune responses, we fed cytochrome c protein to mice transgenic for the beta chain of a cytochrome c-specific TCR and followed the antigen-specific T cell responses with a cyt c/I-Ek tetramer staining reagent. We find that within 6 hr of cytochrome c administration, antigen-specific systemic T cell activation is induced, and spleen cells gain the ability to stimulate cytochrome c-specific T cell responses. Feeding multiple low doses of cytochrome c down-regulates the systemic immune response, which can be correlated with a reduction of antigen-specific T cells and not with immune deviation. These results suggest that systemic distribution of antigen contributes significantly to oral tolerance induction.

journal_name

Immunity

journal_title

Immunity

authors

Gütgemann I,Fahrer AM,Altman JD,Davis MM,Chien YH

doi

10.1016/s1074-7613(00)80571-3

subject

Has Abstract

pub_date

1998-06-01 00:00:00

pages

667-73

issue

6

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80571-3

journal_volume

8

pub_type

杂志文章

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