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Aiolos regulates B cell activation and maturation to effector state.

Abstract：

:Aiolos encodes a zinc finger DNA-binding protein that is highly expressed in mature B cells and is homologous to Ikaros. In the periphery of mice homozygous for an Aiolos-null mutation, B cells exhibit an activated cell surface phenotype and undergo augmented antigen receptor (BCR)-mediated in vitro proliferative responses, even at limiting amounts of stimulant. In vivo, T cell-dependent B cell responses, including the formation of germinal centers and elevated serum IgG and IgE, are detected in Aiolos-deficient mice in the absence of immunization. Auto-antibodies and development of B cell lymphomas are frequently seen among aging Aiolos mutants. In sharp contrast to conventional B cells, B cells of the peritoneum, of the marginal zone, and the recirculating bone marrow population are greatly reduced.

journal_name

Immunity

journal_title

Immunity

authors

Wang JH,Avitahl N,Cariappa A,Friedrich C,Ikeda T,Renold A,Andrikopoulos K,Liang L,Pillai S,Morgan BA,Georgopoulos K

doi

10.1016/s1074-7613(00)80637-8

subject

Has Abstract

pub_date

1998-10-01 00:00:00

pages

543-53

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80637-8

journal_volume

9

pub_type

杂志文章

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