Abstract:
:B cells diversify and affinity mature their antigen receptor repertoire in germinal centers (GCs). GC B cells receive help signals during transient interaction with T cells, yet it remains unknown how these transient T-B interactions in the light zone sustain the subsequent proliferative program of selected B cells that occurs in the anatomically distant dark zone. Here, we show that the transcription factor AP4 was required for sustained GC B cell proliferation and subsequent establishment of a diverse and protective antibody repertoire. AP4 was induced by c-MYC during the T-B interactions, was maintained by T-cell-derived interleukin-21 (IL-21), and promoted repeated rounds of divisions of selected GC B cells. B-cell-specific deletion of AP4 resulted in reduced GC sizes and reduced somatic hypermutation coupled with a failure to control chronic viral infection. These results indicate that AP4 integrates T-cell-mediated selection and sustained expansion of GC B cells for humoral immunity.
journal_name
Immunityjournal_title
Immunityauthors
Chou C,Verbaro DJ,Tonc E,Holmgren M,Cella M,Colonna M,Bhattacharya D,Egawa Tdoi
10.1016/j.immuni.2016.07.023subject
Has Abstractpub_date
2016-09-20 00:00:00pages
570-582issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(16)30296-5journal_volume
45pub_type
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