Abstract:
:In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling.
journal_name
Immunityjournal_title
Immunityauthors
Kortum RL,Samelson LEdoi
10.1016/j.immuni.2008.12.007subject
Has Abstractpub_date
2009-01-16 00:00:00pages
3-5issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(08)00552-9journal_volume
30pub_type
评论,杂志文章相关文献
IMMUNITY文献大全abstract::The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.06.018
更新日期:2008-09-19 00:00:00
abstract::Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCI...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.06.016
更新日期:2014-08-21 00:00:00
abstract::In this issue of Immunity, Trompette et al. (2018) show that dietary fiber and short chain fatty acids reduce influenza A virus-associated immunopathology by enhancing CD8+ T cell effector function and by promoting the differentiation of alternatively activated macrophages. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.05.001
更新日期:2018-05-15 00:00:00
abstract::Distinct metabolic programs support the differentiation of CD4(+) T cells into separate functional subsets. In this study, we investigated metabolic mechanisms underlying the differentiation of IL-9-producing CD4(+) T cells (Th9) in allergic airway inflammation and cancerous tumors. We found that histone deacetylase S...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.05.009
更新日期:2016-06-21 00:00:00
abstract::Assembly of inflammasomes after infection or injury leads to the release of interleukin-1β (IL-1β) and to pyroptosis. After inflammasome activation, cells either pyroptose or enter a hyperactivated state defined by IL-1β secretion without cell death, but what controls these different outcomes is unknown. Here, we show...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.04.005
更新日期:2019-06-18 00:00:00
abstract::Human memory B cells that carry mutated IgV region genes were isolated from tonsils by negative selection of IgD+ naive B cells and CD38+ germinal center B cells and plasma cells. They were mainly found within the intraepithelial areas, but not in the B cell follicles of human tonsils. Memory B cells but not naive B c...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90048-9
更新日期:1995-03-01 00:00:00
abstract::To determine the potential roles of c-jun in lymphocyte development, we generated somatic chimeric mice by injecting homozygous c-jun mutant embryonic stem (ES) cells into blastocysts from recombination activating gene-2 (RAG-2)-deficient mice. Chimeric mice had poor restoration of thymocytes, but contained substantia...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90010-8
更新日期:1994-04-01 00:00:00
abstract::Polyreactivity is the ability of a single antibody to bind to multiple molecularly distinct antigens and is a common feature of antibodies induced upon pathogen exposure. However, little is known about the role of polyreactivity during anti-influenza virus antibody responses. By analyzing more than 500 monoclonal anti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.10.005
更新日期:2020-12-15 00:00:00
abstract::De Libero et al. (2005) demonstrate in this issue of Immunity that bacterial infection leads to increased synthesis of autologous glycolipids that are recognized by CD1-restricted human T cells, indicating that recognition of inducible self-glycolipids could be a mechanism for microbial detection. This mechanism also ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2005.06.001
更新日期:2005-06-01 00:00:00
abstract::A large and diverse array of chemoattractants control leukocyte trafficking, but how these apparently redundant signals collaborate in vivo is still largely unknown. We previously demonstrated an absolute requirement for the lipid chemoattractant leukotriene B(4) (LTB(4)) and its receptor BLT1 for neutrophil recruitme...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.07.018
更新日期:2010-08-27 00:00:00
abstract::Mouse blood monocytes include two main subsets usually discriminated by the expression of the Ly6C surface marker. The study by Mildner et al. (2017) in this issue of Immunity clarifies the transcriptional circuits controlling the generation of Ly6C- cells from their obligate precursors, the Ly6C+ monocytes. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.04.010
更新日期:2017-05-16 00:00:00
abstract::Reciprocal interactions between the metabolic system and immune cells play pivotal roles in diverse inflammatory diseases, but the underlying mechanisms remain elusive. The activation of bile acid-mediated signaling has been linked to improvement in metabolic syndromes and enhanced control of inflammation. Here, we de...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.09.008
更新日期:2016-10-18 00:00:00
abstract::Diet-induced obesity can induce low-level inflammation and insulin resistance. Interleukin-1β (IL-1β) is one of the key proinflammatory cytokines that contributes to the generation of insulin resistance and diabetes, but the mechanisms that regulate obesity-driven inflammation are ill defined. Here we found reduced ex...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.11.013
更新日期:2014-12-18 00:00:00
abstract::Among 631 substitutions present in 90 nurse shark immunoglobulin light chain somatic mutants, 338 constitute 2-4 bp stretches of adjacent changes. An absence of mutations in perinatal sequences and the bias for one mutating V gene in adults suggest that the diversification is antigen dependent. The substitutions share...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00300-x
更新日期:2002-04-01 00:00:00
abstract::Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs. We showed that CD14(+) DCs primed CD4(+) T cells into cells that induce naive B cells to switch isotype and become plasma cells. In contrast, LC...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.07.013
更新日期:2008-09-19 00:00:00
abstract::Why patients with chronic kidney disease have elevated cardiovascular risk remains elusive. In this issue of Immunity, Speer et al. (2013) show that natural modification of high density lipoprotein promotes hypertension through a Toll-like receptor-dependent mechanism. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2013.03.006
更新日期:2013-04-18 00:00:00
abstract::We have characterized the CD1b-mediated presentation pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-presenting cells. The macrophage mannose receptor (MR) was responsible for uptake of LAM. Antagonism of MR function inhibited both the internalization of LAM and the present...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80425-2
更新日期:1997-02-01 00:00:00
abstract::Checkpoint-blocking antibodies can generate potent anti-tumor responses by encouraging the immune system to seek and destroy cancer cells. At this time, the United States Food and Drug Administration has approved three checkpoint-blocking antibodies in three disease indications, and additional approvals are expected t...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2016.04.023
更新日期:2016-05-17 00:00:00
abstract::Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...
journal_title:Immunity
pub_type: 评论,杂志文章,评审
doi:10.1016/j.immuni.2007.02.007
更新日期:2007-02-01 00:00:00
abstract::Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.07.005
更新日期:2005-08-01 00:00:00
abstract::We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, sup...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.01.001
更新日期:2006-02-01 00:00:00
abstract::Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The developmental and functional relationship between individual subsets of monocytes and those of macrophages has not been fully elucidated, although Ly6C(+)CCR2(+...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.11.014
更新日期:2013-03-21 00:00:00
abstract::Immunological functions of mast cells are currently considered to be much broader than the original role of mast cells in IgE-driven allergic disease. The spectrum of proposed mast cell functions includes areas as diverse as the regulation of innate and adaptive immune responses, protective immunity against viral, mic...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2012.07.007
更新日期:2012-07-27 00:00:00
abstract::Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.06.003
更新日期:2020-09-15 00:00:00
abstract::Recent work has identified a new subset of effector T cells that produces interleukin (IL)-17 known as T helper 17 (Th17) cells, which is involved in the pathophysiology of inflammatory diseases and is thought to be developmentally related to regulatory T (Treg) cells. Because of its importance for Treg cells, we exam...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.02.009
更新日期:2007-03-01 00:00:00
abstract::Intraepithelial T lymphocytes possess a (TGF beta)-inducible integrin complex that consists of the beta 7 integrin chain in association with a novel alpha chain, murine alpha M290. Using antibodies directed against the murine alpha M290 chain, IL-3-dependent murine bone marrow-derived mast cells demonstrated positive ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90070-1
更新日期:1994-08-01 00:00:00
abstract::In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.02.009
更新日期:2018-02-20 00:00:00
abstract::While the majority of purified pluripotential hematopoietic stem cells (PHSC) express c-Kit, the receptor for steel factor, we have phenotypically and functionally separated a distinct class of PHSC that does not express c-Kit. In contrast to c-Kit-positive (c-Kit(pos)) PHSC, the c-Kit-negative (c-Kit(neg)) PHSC do no...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80018-7
更新日期:1999-02-01 00:00:00
abstract::Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2006.10.007
更新日期:2006-11-01 00:00:00
abstract::Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cel...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80666-4
更新日期:1998-11-01 00:00:00