Abstract:
:Kupffer cells (KCs) are liver-resident macrophages that self-renew by proliferation in the adult independently from monocytes. However, how they are maintained during non-alcoholic steatohepatitis (NASH) remains ill defined. We found that a fraction of KCs derived from Ly-6C+ monocytes during NASH, underlying impaired KC self-renewal. Monocyte-derived KCs (MoKCs) gradually seeded the KC pool as disease progressed in a response to embryo-derived KC (EmKC) death. Those MoKCs were partly immature and exhibited a pro-inflammatory status compared to EmKCs. Yet, they engrafted the KC pool for the long term as they remained following disease regression while acquiring mature EmKC markers. While KCs as a whole favored hepatic triglyceride storage during NASH, EmKCs promoted it more efficiently than MoKCs, and the latter exacerbated liver damage, highlighting functional differences among KCs with different origins. Overall, our data reveal that KC homeostasis is impaired during NASH, altering the liver response to lipids, as well as KC ontogeny.
journal_name
Immunityjournal_title
Immunityauthors
Tran S,Baba I,Poupel L,Dussaud S,Moreau M,Gélineau A,Marcelin G,Magréau-Davy E,Ouhachi M,Lesnik P,Boissonnas A,Le Goff W,Clausen BE,Yvan-Charvet L,Sennlaub F,Huby T,Gautier ELdoi
10.1016/j.immuni.2020.06.003subject
Has Abstractpub_date
2020-09-15 00:00:00pages
627-640.e5issue
3eissn
1074-7613issn
1097-4180pii
S1074-7613(20)30233-8journal_volume
53pub_type
杂志文章相关文献
IMMUNITY文献大全abstract::We examined the relationship between cell death and tolerance induction following antigen injection into the anterior chamber of the eye. Our data show that when inflammatory cells undergo apoptosis following infection with HSV-1, tolerance to the virus was observed. In contrast, when cell death was absent due to defe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80305-2
更新日期:1996-07-01 00:00:00
abstract::Genetic studies and other experimental data have linked inflammatory bowel diseases with inflammasome activation. In this issue of Immunity, Zaki et al. (2010) and Dupaul-Chicoine et al. (2010) provide a detailed characterization of the regulatory task of the inflammasome in intestinal epithelial cells. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2010.03.010
更新日期:2010-03-26 00:00:00
abstract::Clonal selection theories postulate that lymphocyte fate is regulated by antigen receptor specificity. However, lymphocyte apoptosis is induced through nonantigen-specific receptors such as Fas (CD95/APO-1) or TNFR. We define a selective TCR that controls apoptosis by Fas or TNFR stimulation. Variant ligands can deliv...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80613-5
更新日期:1998-09-01 00:00:00
abstract::Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were an...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90100-7
更新日期:1994-06-01 00:00:00
abstract::Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.02.011
更新日期:2017-03-21 00:00:00
abstract::In a recent issue of Nature, Borges da Silva et al. (2018) reveal that P2RX7, a receptor for extracellular ATP, promotes CD8 T cell memory by enhancing metabolic fitness. This work links an ancient "danger" signal with long-term immunity. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.08.009
更新日期:2018-08-21 00:00:00
abstract::The Toll-like receptor 3 (TLR3) and TLR4-signaling pathway that involves the adaptor protein TRIF activates type I interferon (IFN) and proinflammatory cytokine expression. Little is known about how TRIF pathway-dependent gene expression is regulated. SH2-containing protein tyrosine phosphatase 2 (SHP-2) is a widely e...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.10.014
更新日期:2006-12-01 00:00:00
abstract::SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2020.03.007
更新日期:2020-04-14 00:00:00
abstract::We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising 33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we identified six immune subtypes-wound healing, IFN-γ dominant, inflammatory, lymphocyte depleted, immunologically quiet, and TGF-β dominant-character...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.03.023
更新日期:2018-04-17 00:00:00
abstract::CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00116-x
更新日期:2003-05-01 00:00:00
abstract::Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteri...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.12.020
更新日期:2015-01-20 00:00:00
abstract::Human cytomegalovirus inhibits peptide import into the endoplasmic reticulum (ER) by the MHC-encoded TAP peptide transporter. We identified the open reading frame US6 to mediate this effect. Expression of the 21 kDa US6 glycoprotein in human cytomegalovirus-infected cells correlates with the inhibition of peptide tran...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80350-7
更新日期:1997-05-01 00:00:00
abstract::Fever, an evolutionarily conserved physiological response to infection, is also commonly associated with many autoimmune diseases, but its role in T cell differentiation and autoimmunity remains largely unclear. T helper 17 (Th17) cells are critical in host defense and autoinflammatory diseases, with distinct phenotyp...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.01.006
更新日期:2020-02-18 00:00:00
abstract::Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(95)90013-6
更新日期:1995-06-01 00:00:00
abstract::Memory CD8+ T cell quantity and quality determine protective efficacy against reinfection. Heterologous prime boost vaccination minimizes contraction of anamnestic effectors and maximizes memory CD8+ T cell quantity but reportedly erodes proliferative potential and protective efficacy. This study exploited heterologou...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.07.003
更新日期:2013-07-25 00:00:00
abstract::Monocytes are circulating, short-lived mononuclear phagocytes, which in mice and man comprise two main subpopulations. Murine Ly6C+ monocytes display developmental plasticity and are recruited to complement tissue-resident macrophages and dendritic cells on demand. Murine vascular Ly6C- monocytes patrol the endotheliu...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.04.018
更新日期:2017-05-16 00:00:00
abstract::Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2019.07.001
更新日期:2019-08-20 00:00:00
abstract::Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2005.07.005
更新日期:2005-08-01 00:00:00
abstract::Selectins play a central role in leukocyte trafficking by mediating tethering and rolling on vascular surfaces. Here we have reported that T cell immunoglobulin and mucin domain 1 (TIM-1) is a P-selectin ligand. We have shown that human and murine TIM-1 binds to P-selectin, and that TIM-1 mediates tethering and rollin...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.03.004
更新日期:2014-04-17 00:00:00
abstract::The p38 and JNK stress-activated MAPK signal transduction pathways are activated by T cell receptor (TCR) signaling and are required for IFN-gamma production by TH1 effector cells. Here, we show that the expression of GADD45gamma is induced during T cell activation and that the level of expression is higher in TH1 cel...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00141-8
更新日期:2001-05-01 00:00:00
abstract::The innate immune system comprises several classes of pattern recognition receptors, including Toll-like receptors (TLRs), NOD-like receptors (NLRs), and RIG-1-like receptors (RLRs). TLRs recognize microbes on the cell surface and in endosomes, whereas NLRs and RLRs detect microbial components in the cytosol. Here we ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2007.10.002
更新日期:2007-10-01 00:00:00
abstract::Vgamma2Vdelta2 T cells comprise 2%-5% of human peripheral blood T cells, recognize ubiquitous nonpeptide antigens, and expand up to 50-fold during microbial infection. It is not clear why these Vgamma2Vdelta2 T cells expand only after microbial infection. We show here that the stress-inducible molecule, MICA, is induc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00168-6
更新日期:2001-07-01 00:00:00
abstract::Activated CD8(+) T cells can differentiate into transient effector cells or long-lived memory cells. In this issue of Immunity, Joshi et al. (2007) suggest that inflammatory cytokines dictate this balance by regulating the expression of the transcription factor T-bet. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2007.08.003
更新日期:2007-08-01 00:00:00
abstract::CD4 T cells are pivotal for effective immunity, yet their initial differentiation into effector subsets after infection remains poorly defined. We examined CD4 T cells specific for the immunodominant Leishmania major LACK antigen using MHC/peptide tetramers and IL-4 reporter mice. Comprising approximately 15 cells/lym...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00363-1
更新日期:2002-08-01 00:00:00
abstract::The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential effectors in TNF signaling. To understand the mechanism by which RIP and TRAF2 regulate TNF-induced activation of the transcription factor NF-kappaB, we investigated their respective roles in TNF-R1-mediated IKK activation using...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80194-6
更新日期:2000-04-01 00:00:00
abstract::To establish whether the widely expressed regulator of Src family kinases Csk contributes to the control of acute inflammation in vivo, we inactivated csk in granulocytes by conditional mutagenesis (Cre/loxP). Mutant mice (Csk-GEcre) developed acute multifocal inflammation in skin and lung. Animals were protected from...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(04)00023-8
更新日期:2004-02-01 00:00:00
abstract::Why HIV-specific CD8(+) T cells ultimately fail to clear or control HIV infection is not known. We show here that HIV-specific CD8(+) T cells exhibit increased sensitivity to CD95/Fas-induced apoptosis. This apoptosis is 3-fold higher compared to CMV-specific CD8(+) T cells from the same patients. HIV-specific CD8(+) ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(01)00246-1
更新日期:2001-12-01 00:00:00
abstract::Antibodies against the NANP repeat of circumsporozoite protein (CSP), the major surface antigen of Plasmodium falciparum (Pf) sporozoites, can protect from malaria in animal models but protective humoral immunity is difficult to induce in humans. Here we cloned and characterized rare affinity-matured human NANP-reacti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2017.11.007
更新日期:2017-12-19 00:00:00
abstract::Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2012.09.004
更新日期:2012-09-21 00:00:00
abstract::In this issue of Immunity, Curotto de Lafaille et al. (2008) show that adaptive T regulatory cells control airway inflammation and that it is when they are generated that determines whether they function during acute or chronic inflammation. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.07.001
更新日期:2008-07-18 00:00:00