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Polygenic control of susceptibility to murine systemic lupus erythematosus.

Abstract：

:Susceptibility to glomerulonephritis (GN) and anti-dsDNA autoantibody production was analyzed in crosses with a newly developed systemic lupus erythematosus-susceptible inbred strain, NZM/Aeg2410. The mode of inheritance and the number and location of systemic lupus erythematosus-associated susceptibility loci were analyzed by interval mapping in a backcross with C57BL/6. Three chromosomal intervals containing strong recessive GN susceptibility alleles were identified on chromosomes 1, 4, and 7, each containing several potentially interesting candidate genes. Heterozygosity at H-2 was also found to correlate strongly with GN susceptibility, consistent with previous findings in the NZB/NZW parental strain model. Logistic regression analysis indicated that each of these susceptibility alleles independently accounted for a component of GN susceptibility, and that susceptibility was inherited as a threshold genetic liability in this model system.

journal_name

Immunity

journal_title

Immunity

authors

Morel L,Rudofsky UH,Longmate JA,Schiffenbauer J,Wakeland EK

doi

10.1016/1074-7613(94)90100-7

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

219-29

issue

3

eissn

1074-7613

issn

1097-4180

pii

1074-7613(94)90100-7

journal_volume

1

pub_type

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