Abstract:
:Follicular helper T (Tfh) cells are specialized providers of T cell help to B cells, and are essential for germinal center formation, affinity maturation, and the development of most high-affinity antibodies and memory B cells. Tfh cell differentiation is a multistage, multifactorial process involving B cell lymphoma 6 (Bcl6) and other transcription factors. This article reviews understanding of Tfh cell biology, including their differentiation, migration, transcriptional regulation, and B cell help functions. Tfh cells are critical components of many protective immune responses against pathogens. As such, there is strong interest in harnessing Tfh cells to improve vaccination strategies. Tfh cells also have roles in a range of other diseases, particularly autoimmune diseases. Overall, there have been dramatic advances in this young field, but there is much to be learned about Tfh cell biology in the interest of applying that knowledge to biomedical needs.
journal_name
Immunityjournal_title
Immunityauthors
Crotty Sdoi
10.1016/j.immuni.2014.10.004subject
Has Abstractpub_date
2014-10-16 00:00:00pages
529-42issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(14)00360-4journal_volume
41pub_type
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