当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Pathogen recognition: TLRs throw us a curve.

Pathogen recognition: TLRs throw us a curve.

Abstract：

:Toll-like receptors (TLRs) are the archetypal pattern recognition receptors (PRRs) envisioned by as innate sensors of pathogen attack and host triggers of an adaptive immune response. Two recent papers (Choe et al., 2005; Bell et al., 2005) reveal the distinctive architecture of a TLR sensor domain and hint at how this structural design facilitates the recognition of a wide array of pathogen molecules.

journal_name

Immunity

journal_title

Immunity

authors

Kirk P,Bazan JF

doi

10.1016/j.immuni.2005.09.008

keywords:

subject

Has Abstract

pub_date

2005-10-01 00:00:00

pages

347-50

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(05)00303-1

journal_volume

23

pub_type

杂志文章,评审

相关文献

IMMUNITY文献大全
  • Components of a Stat recognition code: evidence for two layers of molecular selectivity.

    abstract：:Latent and activated forms of Stat1 and Stat6 have been expressed and purified, enabling biochemical experiments relating to their functional activities. Stat1 bound to a phosphotyrosine peptide derived from the IFN gamma receptor with a KD of 50 nM, whereas Stat6 bound to an IL-4 receptor peptide with a KD of 300 nM....

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/1074-7613(95)90013-6

    authors： Schindler U,Wu P,Rothe M,Brasseur M,McKnight SL

    更新日期：1995-06-01 00:00:00

  • Tipping the scales of selection with BAFF.

    abstract：:Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2004.06.001

    authors： Cancro MP

    更新日期：2004-06-01 00:00:00

  • Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells.

    abstract：:By stimulating human lymphocytes with an autologous renal carcinoma, we obtained CTL recognizing an antigen derived from a novel, ubiquitous protein. The CTL failed to lyse autologous EBV-transformed B cells, even though the latter express the protein. This is due to the presence in these cells of immunoproteasomes, w...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80163-6

    authors： Morel S,Lévy F,Burlet-Schiltz O,Brasseur F,Probst-Kepper M,Peitrequin AL,Monsarrat B,Van Velthoven R,Cerottini JC,Boon T,Gairin JE,Van den Eynde BJ

    更新日期：2000-01-01 00:00:00

  • Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events.

    abstract：:Most lineage marker-negative (Lin-)TdT+ cells from murine marrow lack CD34 but display c-kit at low density as well as IL-7Ralpha and Flk-2/Flt-3 receptors. Single cells with these characteristics generated CD45RA+CD19- as well as CD19+ lymphocytes in culture. CD45RA+CD19- marrow cells were resolved into three nonover...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80186-7

    authors： Tudor KS,Payne KJ,Yamashita Y,Kincade PW

    更新日期：2000-03-01 00:00:00

  • Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.

    abstract：:NLRP3 nucleates the inflammasome, a protein complex responsible for cleavage of prointerleukin-1beta (IL-1beta) to its active form. Mutations in the NLRP3 gene cause the autoinflammatory disease spectrum cryopyrin-associated periodic syndromes (CAPS). The central role of IL-1beta in CAPS is supported by the response t...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.05.005

    authors： Brydges SD,Mueller JL,McGeough MD,Pena CA,Misaghi A,Gandhi C,Putnam CD,Boyle DL,Firestein GS,Horner AA,Soroosh P,Watford WT,O'Shea JJ,Kastner DL,Hoffman HM

    更新日期：2009-06-19 00:00:00

  • Oxidation of cofilin mediates T cell hyporesponsiveness under oxidative stress conditions.

    abstract：:Oxidative stress leads to impaired T cell activation. A central integrator of T cell activation is the actin-remodelling protein cofilin. Cofilin is activated through dephosphorylation at Ser3. Activated cofilin enables actin dynamics through severing and depolymerization of F-actin. Binding of cofilin to actin is req...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.06.016

    authors： Klemke M,Wabnitz GH,Funke F,Funk B,Kirchgessner H,Samstag Y

    更新日期：2008-09-19 00:00:00

  • The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.

    abstract：:The thymic medulla provides a microenvironment where medullary thymic epithelial cells (mTECs) express autoimmune regulator and diverse tissue-restricted genes, contributing to launching self-tolerance. Positive selection is essential for thymic medulla formation via a previously unknown mechanism. Here we show that t...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.06.018

    authors： Hikosaka Y,Nitta T,Ohigashi I,Yano K,Ishimaru N,Hayashi Y,Matsumoto M,Matsuo K,Penninger JM,Takayanagi H,Yokota Y,Yamada H,Yoshikai Y,Inoue J,Akiyama T,Takahama Y

    更新日期：2008-09-19 00:00:00

  • Mass Cytometry of the Human Mucosal Immune System Identifies Tissue- and Disease-Associated Immune Subsets.

    abstract：:Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.04.014

    authors： van Unen V,Li N,Molendijk I,Temurhan M,Höllt T,van der Meulen-de Jong AE,Verspaget HW,Mearin ML,Mulder CJ,van Bergen J,Lelieveldt BP,Koning F

    更新日期：2016-05-17 00:00:00

  • Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

    abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.01.006

    authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

    更新日期：2005-02-01 00:00:00

  • NETched in Stone.

    abstract：:Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2019.08.015

    authors： O'Neil LJ,Kaplan MJ

    更新日期：2019-09-17 00:00:00

  • microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells.

    abstract：:microRNA-155 (miR-155) is expressed by cells of the immune system after activation and has been shown to be required for antibody production after vaccination with attenuated Salmonella. Here we show the intrinsic requirement for miR-155 in B cell responses to thymus-dependent and -independent antigens. B cells lackin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.10.009

    authors： Vigorito E,Perks KL,Abreu-Goodger C,Bunting S,Xiang Z,Kohlhaas S,Das PP,Miska EA,Rodriguez A,Bradley A,Smith KG,Rada C,Enright AJ,Toellner KM,Maclennan IC,Turner M

    更新日期：2007-12-01 00:00:00

  • Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function.

    abstract：:The intestinal mucosa promotes T cell responses that might be beneficial for effective mucosal vaccines. However, intestinal resident memory T (Trm) cell formation and function are poorly understood. We found that oral infection with Listeria monocytogenes induced a robust intestinal CD8 T cell response and blocking e...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.03.007

    authors： Sheridan BS,Pham QM,Lee YT,Cauley LS,Puddington L,Lefrançois L

    更新日期：2014-05-15 00:00:00

  • Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy.

    abstract：:The NF-κB pathway plays a crucial role in supporting tumor initiation, progression, and radioresistance of tumor cells. However, the role of the NF-κB pathway in radiation-induced anti-tumor host immunity remains unclear. Here we demonstrated that inhibiting the canonical NF-κB pathway dampened the therapeutic effect ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.07.008

    authors： Hou Y,Liang H,Rao E,Zheng W,Huang X,Deng L,Zhang Y,Yu X,Xu M,Mauceri H,Arina A,Weichselbaum RR,Fu YX

    更新日期：2018-09-18 00:00:00

  • The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.

    abstract：:The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable T cell function remains unclear. Here, we report that T cells lacking both Bax and Bak display defects in antigen-specific proliferation because of Ca(2+)-sign...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2007.05.023

    authors： Jones RG,Bui T,White C,Madesh M,Krawczyk CM,Lindsten T,Hawkins BJ,Kubek S,Frauwirth KA,Wang YL,Conway SJ,Roderick HL,Bootman MD,Shen H,Foskett JK,Thompson CB

    更新日期：2007-08-01 00:00:00

  • Dying to replicate: the orchestration of the viral life cycle, cell death pathways, and immunity.

    abstract：:Manipulation of cell death pathways has been identified as a common feature of host-microbe interactions. We examine two examples: influenza A as a representative acute infection and cytomegalovirus as an example of chronic infection. From the perspective of viral entry, replication, and transmission, we identify poin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.10.010

    authors： Yatim N,Albert ML

    更新日期：2011-10-28 00:00:00

  • T cell receptor delta gene rearrangement and T early alpha (TEA) expression in immature alpha beta lineage thymocytes: implications for alpha beta/gamma delta lineage commitment.

    abstract：:Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80296-4

    authors： Wilson A,de Villartay JP,MacDonald HR

    更新日期：1996-01-01 00:00:00

  • Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies.

    abstract：:Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.11.014

    authors： Conejo-Garcia JR,Rutkowski MR

    更新日期：2015-12-15 00:00:00

  • NLRC3 puts the brakes on STING.

    abstract：:NOD-like receptors (NLRs) are increasingly implicated in regulating pathogen-sensing pathways. In this issue of Immunity, Zhang et al. (2014) describe a role for NLRC3 in regulating STING and the inflammatory response to cytosolic DNA. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.02.007

    authors： Mangan MS,Latz E

    更新日期：2014-03-20 00:00:00

  • Priming the pump: adhesion enhances T cell antigen receptor-induced signaling.

    abstract：:In this issue of Immunity, Conche et al. (2009) define an antigen-independent signaling pathway that is dependent on cyclic adenosine monophosphate and extracellular signal-regulated kinase and T cells for subsequent T cell antigen receptor signaling. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2008.12.007

    authors： Kortum RL,Samelson LE

    更新日期：2009-01-16 00:00:00

  • Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus.

    abstract：:The immune system preserves and makes use of autoreactive lymphocytes with specialized functions. Here we showed that one of these populations, CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique subset of double-positive thymocytes. This subset of cells was precommitted ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2006.08.018

    authors： Gangadharan D,Lambolez F,Attinger A,Wang-Zhu Y,Sullivan BA,Cheroutre H

    更新日期：2006-10-01 00:00:00

  • Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function.

    abstract：:Epithelial cells orchestrate pulmonary homeostasis and pathogen defense and play a crucial role in the initiation of allergic immune responses. Maintaining the balance between homeostasis and inappropriate immune activation and associated pathology is particularly complex at mucosal sites that are exposed to billions ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2015.10.012

    authors： Denney L,Byrne AJ,Shea TJ,Buckley JS,Pease JE,Herledan GM,Walker SA,Gregory LG,Lloyd CM

    更新日期：2015-11-17 00:00:00

  • Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.

    abstract：:La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.02.013

    authors： Mukherjee P,Woods TA,Moore RA,Peterson KE

    更新日期：2013-04-18 00:00:00

  • Feeling a little SYK after mixing BAFF with BCR.

    abstract：:In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.03.001

    authors： Infantino S,Tarlinton DM

    更新日期：2013-03-21 00:00:00

  • Notch 1 signaling regulates peripheral T cell activation.

    abstract：:Notch signaling has been identified as an important regulator of leukocyte differentiation and thymic maturation. Less is known about the role of Notch signaling in regulating mature T cells. We examined the role of Notch 1 in regulating peripheral T cell activity in vitro and in vivo. Coligation of Notch 1 together w...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(04)00081-0

    authors： Eagar TN,Tang Q,Wolfe M,He Y,Pear WS,Bluestone JA

    更新日期：2004-04-01 00:00:00

  • IL-2: Change Structure … Change Function.

    abstract：:In this issue of Immunity, Spangler et al. and Mitra et al. demonstrate how structural changes in the IL-2 molecule alter interactions with the IL-2 receptor, leading to differential cellular targeting and biochemical responses and selective immune consequences. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2015.05.002

    authors： Bluestone JA,Crellin N,Trotta E

    更新日期：2015-05-19 00:00:00

  • NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.

    abstract：:The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, O...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2011.03.026

    authors： Allen IC,Moore CB,Schneider M,Lei Y,Davis BK,Scull MA,Gris D,Roney KE,Zimmermann AG,Bowzard JB,Ranjan P,Monroe KM,Pickles RJ,Sambhara S,Ting JP

    更新日期：2011-06-24 00:00:00

  • A RHIM with a View: FLYing with Functional Amyloids.

    abstract：:Recognition of bacterial peptidoglycan by the Drosophila IMD pathway triggers NF-κB activation and an associated immune response. In this issue of Immunity, Kleino et al. (2017) show that proteins in the IMD pathway form functional amyloids via a cryptic motif resembling the RHIM motif found in mammalian RIPK proteins...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.10.001

    authors： Shin S,Cherry S

    更新日期：2017-10-17 00:00:00

  • IgM Memory Cells: First Responders in Malaria.

    abstract：:Following the fate of antigen-specific memory B cells has been difficult. In this issue of Immunity, Krishnamurty et al. (2016) use a novel B cell tetramer to define Plasmodium-specific memory B cells in parasite-infected mice and demonstrate that after re-infection, somatically mutated IgM(+) memory B cells function ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2016.08.005

    authors： Stone SL,Lund FE

    更新日期：2016-08-16 00:00:00

  • A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation.

    abstract：:Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.04.024

    authors： Ouchida R,Yamasaki S,Hikida M,Masuda K,Kawamura K,Wada A,Mochizuki S,Tagawa M,Sakamoto A,Hatano M,Tokuhisa T,Koseki H,Saito T,Kurosaki T,Wang JY

    更新日期：2008-07-18 00:00:00

  • Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.

    abstract：:Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alve...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2016.11.010

    authors： Kuroda E,Ozasa K,Temizoz B,Ohata K,Koo CX,Kanuma T,Kusakabe T,Kobari S,Horie M,Morimoto Y,Nakajima S,Kabashima K,Ziegler SF,Iwakura Y,Ise W,Kurosaki T,Nagatake T,Kunisawa J,Takemura N,Uematsu S,Hayashi M,Aoshi T

    更新日期：2016-12-20 00:00:00