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Functional assessment of precursors from murine bone marrow suggests a sequence of early B lineage differentiation events.

Abstract：

:Most lineage marker-negative (Lin-)TdT+ cells from murine marrow lack CD34 but display c-kit at low density as well as IL-7Ralpha and Flk-2/Flt-3 receptors. Single cells with these characteristics generated CD45RA+CD19- as well as CD19+ lymphocytes in culture. CD45RA+CD19- marrow cells were resolved into three nonoverlapping subsets. One subset, lacking DX5 and Ly-6C antigens, yielded CD19+ cells in culture. Further analysis demonstrated CD24 on most Lin-TdT+ cells and all CD45R+CD19-DX5-Ly-6C- cells. Mac-1/CD11b was absent from these two subsets of B lineage precursors, while IL-7Ralpha was retained during subsequent differentiation to a CD19+ and stromal cell-independent stage. These findings contrast with previous descriptions of B lymphocyte precursors and suggest a sequence of early differentiation events.

journal_name

Immunity

journal_title

Immunity

authors

Tudor KS,Payne KJ,Yamashita Y,Kincade PW

doi

10.1016/s1074-7613(00)80186-7

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

335-45

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80186-7

journal_volume

12

pub_type

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