Notch 1 signaling regulates peripheral T cell activation.

abstract：:The signaling pathways linked to membrane immunoglobulin (mIg) that are regulated by the coreceptors CD19 and CD22 are not known. The mitogen-activated protein (MAP) kinases ERK2, JNK, and p38 couple extracellular signals to transcriptional responses. The capacity of mIg to activate these MAP kinases is synergisticall...

journal_title：Immunity

authors： Tooze RM,Doody GM,Fearon DT

更新日期：1997-07-01 00:00:00

abstract：:We have identified RORgamma t, a novel, thymus-specific isoform of the orphan nuclear receptor RORgamma that is expressed predominantly in CD4+ CD8+ double-positive thymocytes. Ectopic expression of RORgamma t protects T cell hybridomas from activation-induced cell death by inhibiting the upregulation of Fas ligand. F...

journal_title：Immunity

authors： He YW,Deftos ML,Ojala EW,Bevan MJ

更新日期：1998-12-01 00:00:00

abstract：:What does it take to make a regulatory T (Treg) cell? In this issue of Immunity, Ohkura et al. show that Treg-cell-specific CpG hypomethylation and Foxp3 expression are independent events required for Treg cell development, stability, and full suppressive activity. ...

journal_title：Immunity

authors： Delgoffe GM,Bettini ML,Vignali DA

更新日期：2012-11-16 00:00:00

abstract：:The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinical models. Here, we examined the role of CD226 in the function of tumor-infiltrating lymphocytes (TILs) and resistance to immunotherapy. In murine tumors, a large proportion of CD8+ TILs ha...

journal_title：Immunity

authors： Braun M,Aguilera AR,Sundarrajan A,Corvino D,Stannard K,Krumeich S,Das I,Lima LG,Meza Guzman LG,Li K,Li R,Salim N,Jorge MV,Ham S,Kelly G,Vari F,Lepletier A,Raghavendra A,Pearson S,Madore J,Jacquelin S,Effern M,

更新日期：2020-10-13 00:00:00

abstract：:Using a transgenic approach, we examined distal regulatory elements located in the IL-4 locus and the role of GATA-3 at these elements. The intergenic DNase I hypersensitive sites (HSS) showed strong enhancement, and the intronic enhancer (IE) and HS5/HS5a sites showed weaker enhancement of the IL-4 promoter. Elements...

journal_title：Immunity

authors： Lee GR,Fields PE,Flavell RA

更新日期：2001-04-01 00:00:00

abstract：:The effector potential of NK cells is counterbalanced by their sensitivity to inhibition by "self" MHC class I molecules in a process called "education." In humans, interactions between inhibitory killer immunoglobulin-like receptors (KIR) and human MHC (HLA) mediate NK cell education. In HLA-B(∗)27:05(+) transgenic m...

journal_title：Immunity

authors： Boudreau JE,Liu XR,Zhao Z,Zhang A,Shultz LD,Greiner DL,Dupont B,Hsu KC

更新日期：2016-08-16 00:00:00

abstract：:Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation. ...

journal_title：Immunity

authors： Cancro MP

更新日期：2004-06-01 00:00:00

abstract：:Activation of the innate immune response in Metazoans is initiated through the recognition of microbes by host pattern-recognition receptors. In Drosophila, diaminopimelic acid (DAP)-containing peptidoglycan from Gram-negative bacteria is detected by the transmembrane receptor PGRP-LC and by the intracellular receptor...

journal_title：Immunity

authors： Iatsenko I,Kondo S,Mengin-Lecreulx D,Lemaitre B

更新日期：2016-11-15 00:00:00

abstract：:Most lineage marker-negative (Lin-)TdT+ cells from murine marrow lack CD34 but display c-kit at low density as well as IL-7Ralpha and Flk-2/Flt-3 receptors. Single cells with these characteristics generated CD45RA+CD19- as well as CD19+ lymphocytes in culture. CD45RA+CD19- marrow cells were resolved into three nonover...

journal_title：Immunity

authors： Tudor KS,Payne KJ,Yamashita Y,Kincade PW

更新日期：2000-03-01 00:00:00

abstract：:The intestinal microbiota shapes and directs immune development locally and systemically, but little is known about whether commensal microbes in the stomach can impact their immunological microenvironment. Here, we report that group 2 innate lymphoid cells (ILC2s) were the predominant ILC subset in the stomach and sh...

journal_title：Immunity

authors： Satoh-Takayama N,Kato T,Motomura Y,Kageyama T,Taguchi-Atarashi N,Kinoshita-Daitoku R,Kuroda E,Di Santo JP,Mimuro H,Moro K,Ohno H

更新日期：2020-04-14 00:00:00

abstract：:In this issue of Immunity, studies from Atherly et al (2006) and Broussard et al. (2006) show that mice deficient in Tec kinases support development of a population of CD8(+) T cells with "innate-immune" properties. The similarity of these cells to NKT and MHC-class-Ib-restricted T cells suggests a common developmenta...

journal_title：Immunity

authors： Hogquist KA

更新日期：2006-07-01 00:00:00

abstract：:The emerging notion of environment-induced reprogramming of Foxp3(+) regulatory T (Treg) cells into helper T (Th) cells remains controversial. By genetic fate mapping or adoptive transfers, we have identified a minor population of nonregulatory Foxp3(+) T cells exhibiting promiscuous and transient Foxp3 expression, wh...

journal_title：Immunity

authors： Miyao T,Floess S,Setoguchi R,Luche H,Fehling HJ,Waldmann H,Huehn J,Hori S

更新日期：2012-02-24 00:00:00

abstract：:Circulating lymphocytes home to the mucosal lymphoid organs, Peyer's patches (PP), through high endothelial venules (HEV). In situ analyses revealed that transfused lymph node cells (LNCs) interact with PP-HEV in a series of overlapping adhesion events: L-selectin (CD62L) > alpha 4 beta 7 initiates interaction, L-sele...

journal_title：Immunity

authors： Bargatze RF,Jutila MA,Butcher EC

更新日期：1995-07-01 00:00:00

abstract：:Co-evolution with their bacterial hosts has led to viral countermeasures against CRISPR-mediated immunity. In a recent issue of Cell, Landsberger et al. (2018) and Borges et al. (2018) report that cooperation among bacteriophages and multiple infection events are necessary to overcome CRISPR immune responses. ...

journal_title：Immunity

authors： van Gent M,Gack MU

更新日期：2018-09-18 00:00:00

abstract：:Chronic inflammatory diseases represent an increasing medical burden, yet neither tools to predict the individual disease course nor causal cures are at hand. We discuss opportunities for systems medicine to derive precise, individualized disease models and outline the European consortium SYSCID as part of the roadmap...

journal_title：Immunity

authors： Schultze JL,SYSCID consortium.,Rosenstiel P

更新日期：2018-04-17 00:00:00

abstract：:In this issue of Immunity, Chaudhry et al. (2011) and Huber et al. (2011) report that control of Th17 cell responses during colonic inflammation requires direct signaling by IL-10 in regulatory T cells and Th17 cells. ...

journal_title：Immunity

authors： Stewart CA,Trinchieri G

更新日期：2011-04-22 00:00:00

abstract：:Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ...

journal_title：Immunity

authors： Elliott EI,Sutterwala FS

更新日期：2016-04-19 00:00:00

abstract：:Mutations affecting the Tec kinases Itk and Rlk decrease T cell receptor-induced Ca(2+) mobilization and Erk kinase activation and impair both positive and negative thymic selection. Itk(-/-) and Rlk(-/-)Itk(-/-) mice also have decreased CD4:8 T cell ratios, suggestive of altered CD4:8 lineage commitment. Nonetheless,...

journal_title：Immunity

authors： Broussard C,Fleischacker C,Horai R,Chetana M,Venegas AM,Sharp LL,Hedrick SM,Fowlkes BJ,Schwartzberg PL

更新日期：2006-07-01 00:00:00

abstract：:Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. R...

journal_title：Immunity

authors： Rosser EC,Mauri C

更新日期：2015-04-21 00:00:00

abstract：:Two families of protein tyrosine kinases (PTKs), the Src and Syk/ZAP-70 families, are required for T cell development. Lck is the major Src family member required for thymopoiesis, since there is a severe deficit of CD4+CD8+ thymocytes and mature T cells in its absence. However, some peripheral T cells are evident in ...

journal_title：Immunity

authors： van Oers NS,Lowin-Kropf B,Finlay D,Connolly K,Weiss A

更新日期：1996-11-01 00:00:00

abstract：:The development, validation, and appropriate application of serological assays to detect antibodies to SARS-CoV-2 are essential to determining seroprevalence of this virus in the United States and globally and in guiding government leadership and the private sector on back-to-work policies. An interagency working grou...

journal_title：Immunity

authors： Lerner AM,Eisinger RW,Lowy DR,Petersen LR,Humes R,Hepburn M,Cassetti MC

更新日期：2020-07-14 00:00:00

abstract：:Inflammatory intestinal diseases are characterized by abnormal immune responses and affect distinct locations of the gastrointestinal tract. Although the role of several immune subsets in driving intestinal pathology has been studied, a system-wide approach that simultaneously interrogates all major lineages on a sing...

journal_title：Immunity

authors： van Unen V,Li N,Molendijk I,Temurhan M,Höllt T,van der Meulen-de Jong AE,Verspaget HW,Mearin ML,Mulder CJ,van Bergen J,Lelieveldt BP,Koning F

更新日期：2016-05-17 00:00:00

abstract：:Elevated inflammation in the female genital tract is associated with increased HIV risk. Cervicovaginal bacteria modulate genital inflammation; however, their role in HIV susceptibility has not been elucidated. In a prospective cohort of young, healthy South African women, we found that individuals with diverse genita...

journal_title：Immunity

authors： Gosmann C,Anahtar MN,Handley SA,Farcasanu M,Abu-Ali G,Bowman BA,Padavattan N,Desai C,Droit L,Moodley A,Dong M,Chen Y,Ismail N,Ndung'u T,Ghebremichael MS,Wesemann DR,Mitchell C,Dong KL,Huttenhower C,Walker BD,Virgi

更新日期：2017-01-17 00:00:00

abstract：:Blood, lymphoid tissues, and placenta contain diverse subpopulations of natural killer (NK) cells that possess distinct immune functions. Recent studies have shown that human and mouse gut-associated lymphoid tissues harbor a unique NK cell subset that specializes in production of interleukin (IL)-22. This cytokine pl...

journal_title：Immunity

authors： Colonna M

更新日期：2009-07-17 00:00:00

abstract：:Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor mediating innate antimicrobial immunity. It catalyzes the synthesis of a noncanonical cyclic dinucleotide, 2',5' cGAMP, that binds to STING and mediates the activation of TBK1 and IRF-3. Activated IRF-3 translocates to the nucleus and initiates the transcription...

journal_title：Immunity

authors： Li X,Shu C,Yi G,Chaton CT,Shelton CL,Diao J,Zuo X,Kao CC,Herr AB,Li P

更新日期：2013-12-12 00:00:00

abstract：:Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...

journal_title：Immunity

authors： Weber JR,Freyer D,Alexander C,Schröder NW,Reiss A,Küster C,Pfeil D,Tuomanen EI,Schumann RR

更新日期：2003-08-01 00:00:00

abstract：:Contradictory to previous reports, Iatsenko et al. (2016) reveal that PGRP-SD regulates the Imd signaling pathway rather than the Toll pathway in Drosophila and shed light on a decade-old mystery of conflicting structural and phenotypic data. ...

journal_title：Immunity

authors： Monahan A,Kleino A,Silverman N

更新日期：2016-11-15 00:00:00

abstract：:TNF clearly contributes to immunity to intracellular pathogens, but how it does so is incompletely understood. In this issue of Immunity, Clay et al. (2008) provide unique insights, using intravital microscopy and the zebrafish-embryo model of tuberculosis. ...

journal_title：Immunity

authors： Miller EA,Ernst JD

更新日期：2008-08-15 00:00:00

abstract：:Murine natural killer cells selectively express members of the Ly49 family of class I MHC receptors; however, the molecular mechanism controlling probabilistic expression of Ly49 proteins has not been defined. A pair of overlapping, divergent promoters discovered in the Ly49g gene functions as a molecular switch that ...

journal_title：Immunity

authors： Saleh A,Davies GE,Pascal V,Wright PW,Hodge DL,Cho EH,Lockett SJ,Abshari M,Anderson SK

更新日期：2004-07-01 00:00:00

abstract：:Viral infection triggers host innate immune responses that result in the production of various cytokines including type I interferons (IFN), activation of inflammasomes, and programmed cell death of the infected cells. Tight control of inflammatory cytokine production is crucial for the triggering of an effective immu...

journal_title：Immunity

authors： Wang Y,Ning X,Gao P,Wu S,Sha M,Lv M,Zhou X,Gao J,Fang R,Meng G,Su X,Jiang Z

更新日期：2017-03-21 00:00:00