Abstract:
:Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. Recent work has shown that different inflammatory environments induce distinct Breg cell populations. Although these findings highlight the relevance of inflammatory signals in the differentiation of Breg cells, they also raise other questions about Breg cell biology and phenotype. For example, what are the functional properties and phenotype of Breg cells? Can a Breg cell arise at every stage in B cell development? Is inflammation the primary requisite for Breg cell differentiation? Here, we use these questions to discuss the advances in understanding Breg cell biology, with a particular emphasis on their ontogeny; we propose that multiple Breg cell subsets can be induced in response to inflammation at different stages in development.
journal_name
Immunityjournal_title
Immunityauthors
Rosser EC,Mauri Cdoi
10.1016/j.immuni.2015.04.005subject
Has Abstractpub_date
2015-04-21 00:00:00pages
607-12issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(15)00134-Xjournal_volume
42pub_type
杂志文章,评审相关文献
IMMUNITY文献大全abstract::Destruction of li by proteolysis is required for MHC class II molecules to bind antigenic peptides, and for transport of the resulting complexes to the cell surface. The cysteine protease cathepsin S is highly expressed in spleen, lymphocytes, monocytes, and other class II-positive cells, and is inducible with interfe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80249-6
更新日期:1996-04-01 00:00:00
abstract::Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specif...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.012
更新日期:2019-02-19 00:00:00
abstract::After antigen-driven expansion, the majority of T cells involved in an immune response die rapidly by apoptosis dependent on the Bcl-2 related proteins, Bim and Bax or Bak. The details of how these proteins are activated and interact are still unclear. The crystal structure of mouse Bcl-x(L) bound to a long helical fr...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00234-6
更新日期:2003-09-01 00:00:00
abstract::Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.03.015
更新日期:2016-04-19 00:00:00
abstract::Cyclophilin A (CypA/Ppia) is a peptidyl-prolyl isomerase (PPIase) that binds the immunosuppressive drug cyclosporine. The resulting complex blocks T cell function by inhibiting the calcium-dependent phosphatase calcineurin. To identify the native function of CypA, long suspected of regulating signal transduction, we g...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2004.07.005
更新日期:2004-08-01 00:00:00
abstract::Shigella pathogenesis has confounded researchers for years because of its narrow host selectivity and extraordinary infectious capability. In this issue of Immunity, Xu et al. (2018) identify a cunning mechanism whereby Shigella hijacks human α-defensin 5 to enhance its adhesion and subsequent invasion. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.05.015
更新日期:2018-06-19 00:00:00
abstract::CXCR5, the receptor for B lymphocyte chemoattractant (BLC), is required for normal development of Peyer's patches, inguinal lymph nodes, and splenic follicles. To test the in vivo activity of BLC in isolation of other lymphoid organizers, transgenic mice were generated expressing BLC in the pancreatic islets. In addit...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80199-5
更新日期:2000-05-01 00:00:00
abstract::Mutant RAS is a major oncoprotein in human cancer and PD-L1 is a key driver of cancer immune evasion. In this issue of Immunity, Coelho et al. (2017) demonstrate that oncogenic RAS signaling promotes tumor immune escape by stabilizing PD-L1 mRNA. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2017.12.001
更新日期:2017-12-19 00:00:00
abstract::B-lymphoid and myeloid development are markedly perturbed in a unique transgenic mouse strain, max 41. Pro-B, pre-B, and B lymphocytes were severely reduced but granulocytes were greatly elevated. This phenotype could be adoptively transferred with bone marrow cells. It was not alleviated by bcl-2 or myc transgenes th...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/1074-7613(94)90094-9
更新日期:1994-09-01 00:00:00
abstract::La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.02.013
更新日期:2013-04-18 00:00:00
abstract::Foxp3(+) Treg cells express transcription factors normally expressed by specific T helper cells at sites of inflammation. In this issue of Immunity, Koch et al. (2012) and Hall et al. (2012) demonstrate that IFN-γ and IL-27 distinctly induces T-bet(+) Treg cells via STAT-1 transcription factor activation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2012.09.004
更新日期:2012-09-21 00:00:00
abstract::Monocytes and macrophages are important effectors and regulators of inflammation, and both can be divided into distinct subsets based on their phenotypes. The developmental and functional relationship between individual subsets of monocytes and those of macrophages has not been fully elucidated, although Ly6C(+)CCR2(+...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.11.014
更新日期:2013-03-21 00:00:00
abstract::Upon TCR engagement, naive CD4 T cells differentiate toward the Th1 or Th2 phenotype. IL-4, acting through Stat6, plays a major role in Th2 differentiation; IL-2 has also been reported to be essential. Here, we report that retroviral (RV)-mediated expression of a constitutively active Stat5A mutant (STAT5A1*6) can ful...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00292-9
更新日期:2003-11-01 00:00:00
abstract::In this issue of Immunity, Mrdjen et al. (2018) use high-dimensional single-cell proteomics and high parametric mass cytometry to provide insight into the long-lasting issue of how to identify and characterize both resident and recruited leukocyte populations in healthy, aged, and diseased CNS. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2018.02.009
更新日期:2018-02-20 00:00:00
abstract::Antigenic peptides are translocated by the TAP peptide transporter from the cytosol into the endoplasmic reticulum (ER) for loading onto MHC class I molecules. Peptides that fail to bind need to be removed from the ER. Here we provide evidence that peptide export utilizes the Sec61p translocon as demonstrated by block...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00013-3
更新日期:2000-07-01 00:00:00
abstract::The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefo...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.04.023
更新日期:2020-06-16 00:00:00
abstract::Reorganization of the actin cytoskeleton requires nucleating factors, which initiate actin fiber formation. In this issue of Immunity, the functions of two classes of actin nucleators are examined in T lymphocytes, giving insight into the regulation of T cell polarity (Gomez et al., 2007). ...
journal_title:Immunity
pub_type: 评论,杂志文章,评审
doi:10.1016/j.immuni.2007.02.007
更新日期:2007-02-01 00:00:00
abstract::Transcriptional regulation of the Nos2 gene encoding inducible nitric oxide synthase (iNOS) requires type I interferon (IFN-I) signaling and additional signals emanating from pattern recognition receptors. Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2010.07.001
更新日期:2010-07-23 00:00:00
abstract::To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80090-4
更新日期:1999-08-01 00:00:00
abstract::Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...
journal_title:Immunity
pub_type: 信件
doi:10.1016/j.immuni.2009.09.007
更新日期:2009-10-16 00:00:00
abstract::The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expression is insufficient for establishing the Treg cell lineage. Here we showed that Treg cell development was achieved by the combination of two independent processes, i.e., the expression of Foxp3 and the establis...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.09.010
更新日期:2012-11-16 00:00:00
abstract::T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2007.12.006
更新日期:2008-01-01 00:00:00
abstract::T helper 17 (Th17) cells play an important role in mucosal host defense through production of the signature cytokines IL-17 and IL-22. Prostaglandin E2 (PGE2) has been shown to enhance IL-17 production by mature Th17 cells. However, when present during Th17 cell differentiation, we found that PGE2 inhibited the transc...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2012.02.013
更新日期:2012-04-20 00:00:00
abstract::The mitochondrial antiviral signaling protein (MAVS) mediates the activation of NFkappaB and IRFs and the induction of interferons in response to viral infection. In vitro studies have also suggested that MAVS is required for interferon induction by cytosolic DNA, but the in vivo evidence is lacking. By generating MAV...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.04.004
更新日期:2006-05-01 00:00:00
abstract::Caspases are an evolutionary conserved family of cysteine proteases that are centrally involved in cell death and inflammation responses. A wealth of foundational insight into the molecular mechanisms that control caspase activation has emerged in recent years. Important advancements include the identification of addi...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2019.05.020
更新日期:2019-06-18 00:00:00
abstract::PCR analyses of the kappaL chain locus in single B-lineage cells of wild-type, Ckappa-, or JCkappa-deficient homozygous or heterozygous mice often detect multiple in- and out-of-frame rearrangements at the kappaL and lambdaL loci. They are most frequent in small pre-BII cells and equally so in wild-type and kappaL cha...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80107-7
更新日期:1999-09-01 00:00:00
abstract::Cytokines can provide survival and proliferation signals to cancer cells, thus promoting tumor progression. In this issue of Immunity, Kryczek et al. (2014) reveal that interleukin-22 can also promote "stemness" in human colorectal cancer via transcription factor STAT3-mediated epigenetic regulation of stem cell genes...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2014.04.014
更新日期:2014-05-15 00:00:00
abstract::Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. The TCR is rapidly internalized after antigen stimulation and then degraded in lysosomes. However, few of the molecules involved...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.04.024
更新日期:2008-07-18 00:00:00
abstract::Inflammation can activate self-reactive CD8(+) T cells and induce autoimmunity. Here we show in a CD8(+) T cell-mediated model of type 1 diabetes that CD4(+)CD25(+) Treg cells prevent beta cell destruction following localized inflammation in the islets of Langerhans. These Treg cells accumulate preferentially in the p...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00279-0
更新日期:2002-02-01 00:00:00
abstract::Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response ac...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2011.08.015
更新日期:2011-10-28 00:00:00