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Frequencies of multiple IgL chain gene rearrangements in single normal or kappaL chain-deficient B lineage cells.

Abstract：

:PCR analyses of the kappaL chain locus in single B-lineage cells of wild-type, Ckappa-, or JCkappa-deficient homozygous or heterozygous mice often detect multiple in- and out-of-frame rearrangements at the kappaL and lambdaL loci. They are most frequent in small pre-BII cells and equally so in wild-type and kappaL chain-deficient cells. Hence, kappaL chain production appears not to inhibit secondary rearrangements. Around 20% of all small preBII cells express IgL chains in their cytoplasm. Cells with a first productive rearrangement on one allele are favored to enter the immature B cell compartment. Thus, allelic exclusion might be secured by control of accessibility of IgL chain loci for rearrangement and by rapid selection of cells with a fitting over those with a nonfitting IgL chain.

journal_name

Immunity

journal_title

Immunity

authors

Yamagami T,ten Boekel E,Andersson J,Rolink A,Melchers F

doi

10.1016/s1074-7613(00)80107-7

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

317-27

issue

3

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(00)80107-7

journal_volume

11

pub_type

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