当前位置： SCI文献检索 > IMMUNITY期刊下所有文献 > Monocytes Take Their Own Path to IL-1β.

Monocytes Take Their Own Path to IL-1β.

Abstract：

:Generally, two signals are required to activate the NLRP3 inflammasome. In this issue of Immunity, Hornung and colleagues (2016) describe an alternative inflammasome activation pathway in human monocytes triggering activation of the NLRP3 inflammasome in response to a single stimulus.

journal_name

Immunity

journal_title

Immunity

authors

Elliott EI,Sutterwala FS

doi

10.1016/j.immuni.2016.03.015

subject

Has Abstract

pub_date

2016-04-19 00:00:00

pages

713-5

issue

4

eissn

1074-7613

issn

1097-4180

pii

S1074-7613(16)30104-2

journal_volume

44

pub_type

评论,杂志文章

相关文献

IMMUNITY文献大全
  • Calcineurin B1 is essential for positive but not negative selection during thymocyte development.

    abstract：:During development, discrete cell fates often result from variation in the intensity of a particular signal. The mechanisms underlying these seemingly analog-to-digital switches are not understood. In developing T lymphocytes, low-intensity signals through the antigen receptor result in positive selection while more i...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(04)00052-4

    authors： Neilson JR,Winslow MM,Hur EM,Crabtree GR

    更新日期：2004-03-01 00:00:00

  • Whole-body anatomy of human T cells.

    abstract：:Knowledge of the regional tissue distribution of T cell subsets is a prerequisite for understanding protective immunity and the pathophysiology of T cell-mediated diseases. In this issue of Immunity, Sathaliyawala et al. (2012) present a comprehensive human tissue T cell analysis. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2013.01.006

    authors： Neuenhahn M,Busch DH

    更新日期：2013-01-24 00:00:00

  • Spatial separation of HLA-DM/HLA-DR interactions within MIIC and phagosome-induced immune escape.

    abstract：:Major Histocompatibility Complex (MHC) class II molecules, including Human Leukocyte Antigen (HLA)-DR, present peptide fragments from proteins degraded in the endocytic pathway. HLA-DR is targeted to late-endocytic structures named MHC class II-containing Compartments (MIIC), where it interacts with HLA-DM. This chape...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2005.01.006

    authors： Zwart W,Griekspoor A,Kuijl C,Marsman M,van Rheenen J,Janssen H,Calafat J,van Ham M,Janssen L,van Lith M,Jalink K,Neefjes J

    更新日期：2005-02-01 00:00:00

  • Targeting the function of mature dendritic cells by human cytomegalovirus: a multilayered viral defense strategy.

    abstract：:Human cytomegalovirus (HCMV) can suppress and evade the immune system. We have identified as a mechanism the ability of HCMV to infect dendritic cells (DC), which initiate the antiviral immune response. HCMV-infected DC show enhanced expression of costimulatory molecules. In contrast, MHC molecules are partially downr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00239-4

    authors： Raftery MJ,Schwab M,Eibert SM,Samstag Y,Walczak H,Schönrich G

    更新日期：2001-12-01 00:00:00

  • Unexpected steps in plasma-cell differentiation.

    abstract：:The transcriptional repressor Blimp-1 is considered the master regulator of plasma-cell differentiation. In this issue of Immunity, Kallies et al. (2007) identify a Blimp-1-independent stage of differentiation, followed by Blimp-1-dependent terminal differentiation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2007.05.005

    authors： Klein U,Dalla-Favera R

    更新日期：2007-05-01 00:00:00

  • A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex.

    abstract：:The elongated complementary-determining region (CDR) 3beta found in the unliganded KB5-C20 TCR protrudes from the antigen binding site and prevents its docking onto the peptide/MHC (pMHC) surface according to a canonical diagonal orientation. We now present the crystal structure of a complex involving the KB5-C20 TCR ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00288-1

    authors： Reiser JB,Grégoire C,Darnault C,Mosser T,Guimezanes A,Schmitt-Verhulst AM,Fontecilla-Camps JC,Mazza G,Malissen B,Housset D

    更新日期：2002-03-01 00:00:00

  • Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators.

    abstract：:Fibroblasts are major contributors to and regulators of inflammation and dominant producers of interleukin-6 (IL-6) in inflammatory diseases like rheumatoid arthritis. Yet, compared to leukocytes, the regulation of inflammatory pathways in fibroblasts is largely unknown. Here, we report that analyses of genes coordina...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.01.004

    authors： Nguyen HN,Noss EH,Mizoguchi F,Huppertz C,Wei KS,Watts GFM,Brenner MB

    更新日期：2017-02-21 00:00:00

  • SARS-CoV-2 Vaccines: Status Report.

    abstract：:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2020.03.007

    authors： Amanat F,Krammer F

    更新日期：2020-04-14 00:00:00

  • Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.

    abstract：:To explain why solid cancers grow or are rejected, we examined how the tumor stroma affected the level of antigen expression necessary to induce an immune response. We applied a tamoxifen-regulated Cre-loxP system to induce a model SIYRYYGL antigen recognized by the 2C T cell receptor. Solid tumors expressing the anti...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(02)00480-6

    authors： Spiotto MT,Yu P,Rowley DA,Nishimura MI,Meredith SC,Gajewski TF,Fu YX,Schreiber H

    更新日期：2002-12-01 00:00:00

  • Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire.

    abstract：:In T cell-dependent immune responses, high-affinity B cells are selected and differentiate into memory cells; however, the mechanism behind this process remains largely unknown. Here, we report that the selection of high-affinity B cells within germinal centers (GCs) is impaired in Fas-deficient lpr mice in the primar...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(01)00100-5

    authors： Takahashi Y,Ohta H,Takemori T

    更新日期：2001-02-01 00:00:00

  • Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

    abstract：:Despite the importance of Th17 cells in autoimmune diseases, it remains unclear how they control other inflammatory cells in autoimmune tissue damage. Using a model of spontaneous autoimmune arthritis, we showed that arthritogenic Th17 cells stimulated fibroblast-like synoviocytes via interleukin-17 (IL-17) to secrete...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2018.04.009

    authors： Hirota K,Hashimoto M,Ito Y,Matsuura M,Ito H,Tanaka M,Watanabe H,Kondoh G,Tanaka A,Yasuda K,Kopf M,Potocnik AJ,Stockinger B,Sakaguchi N,Sakaguchi S

    更新日期：2018-06-19 00:00:00

  • Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.

    abstract：:The stromal scaffold of the lymph node (LN) paracortex is built by fibroblastic reticular cells (FRCs). Conditional ablation of lymphotoxin-β receptor (LTβR) expression in LN FRCs and their mesenchymal progenitors in developing LNs revealed that LTβR-signaling in these cells was not essential for the formation of LNs....

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2013.03.012

    authors： Chai Q,Onder L,Scandella E,Gil-Cruz C,Perez-Shibayama C,Cupovic J,Danuser R,Sparwasser T,Luther SA,Thiel V,Rülicke T,Stein JV,Hehlgans T,Ludewig B

    更新日期：2013-05-23 00:00:00

  • Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

    abstract：:Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(04)00107-4

    authors： Herbert DR,Hölscher C,Mohrs M,Arendse B,Schwegmann A,Radwanska M,Leeto M,Kirsch R,Hall P,Mossmann H,Claussen B,Förster I,Brombacher F

    更新日期：2004-05-01 00:00:00

  • Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

    abstract：:Regulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that the c-Rel transcription factor controlled development of Treg...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2009.10.006

    authors： Ruan Q,Kameswaran V,Tone Y,Li L,Liou HC,Greene MI,Tone M,Chen YH

    更新日期：2009-12-18 00:00:00

  • Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer.

    abstract：:Numerous regulatory programs have been identified that contribute to the restoration of homeostasis at the conclusion of immune responses and to safeguarding against the detrimental effects of chronic inflammation and autoimmune pathology. Malignant cells may usurp these pathways to create immunosuppressive networks t...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2012.03.004

    authors： Rabinovich GA,Croci DO

    更新日期：2012-03-23 00:00:00

  • Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.

    abstract：:Differentiation of memory cells involves DNA-sequence changes in B lymphocytes but is less clearly defined in T cells. RNA rearrangement is identified here as a key event in memory T cell differentiation by analysis of a mouse mutation that altered the proportions of naive and memory T cells and crippled the process o...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2008.11.004

    authors： Wu Z,Jia X,de la Cruz L,Su XC,Marzolf B,Troisch P,Zak D,Hamilton A,Whittle B,Yu D,Sheahan D,Bertram E,Aderem A,Otting G,Goodnow CC,Hoyne GF

    更新日期：2008-12-19 00:00:00

  • Tipping the scales of selection with BAFF.

    abstract：:Two recent Immunity papers link peripheral tolerance with the ability of developing B cells to capture BAFF. These findings suggest that an increase in effective BAFF levels leads to autoreactive B cell maturation. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2004.06.001

    authors： Cancro MP

    更新日期：2004-06-01 00:00:00

  • Why aging T cells fail: implications for vaccination.

    abstract：:The decline in CD4+ T cell function with aging contributes to reduced vaccine efficacy. In this commentary, we discuss the factors leading to age-related changes in T cell function and propose how they may be overcome to enhance vaccine efficacy for the elderly. ...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2006.06.003

    authors： Haynes L,Swain SL

    更新日期：2006-06-01 00:00:00

  • MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota.

    abstract：:Graft-versus-host disease (GVHD) in the gastrointestinal (GI) tract is the principal determinant of lethality following allogeneic bone marrow transplantation (BMT). Here, we examined the mechanisms that initiate GVHD, including the relevant antigen-presenting cells. MHC class II was expressed on intestinal epithelial...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.08.011

    authors： Koyama M,Mukhopadhyay P,Schuster IS,Henden AS,Hülsdünker J,Varelias A,Vetizou M,Kuns RD,Robb RJ,Zhang P,Blazar BR,Thomas R,Begun J,Waddell N,Trinchieri G,Zeiser R,Clouston AD,Degli-Esposti MA,Hill GR

    更新日期：2019-11-19 00:00:00

  • Toll-like receptor 9, what o'clock is it?

    abstract：:In this issue of Immunity, Silver et al. (2012) provide evidence that murine Toll-like receptor 9 (TLR9) expression and function in innate and adaptive immunity is controlled by the circadian cycle. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2012.02.003

    authors： Obermann HL,Bauer S

    更新日期：2012-02-24 00:00:00

  • Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function.

    abstract：:Tissue macrophages arise during embryogenesis from yolk-sac (YS) progenitors that give rise to primitive YS macrophages. Until recently, it has been impossible to isolate or derive sufficient numbers of YS-derived macrophages for further study, but data now suggest that induced pluripotent stem cells (iPSCs) can be dr...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2017.06.017

    authors： Takata K,Kozaki T,Lee CZW,Thion MS,Otsuka M,Lim S,Utami KH,Fidan K,Park DS,Malleret B,Chakarov S,See P,Low D,Low G,Garcia-Miralles M,Zeng R,Zhang J,Goh CC,Gul A,Hubert S,Lee B,Chen J,Low I,Shadan NB,Lum J

    更新日期：2017-07-18 00:00:00

  • Virus-specific CD8 T cells in peripheral tissues are more resistant to apoptosis than those in lymphoid organs.

    abstract：:CD8 T cells persist at high frequencies in peripheral organs after resolution of an immune response, and their presence in the periphery is important for resistance to secondary challenge. We show here that LCMV-specific T cells in peripheral tissue (peritoneal cavity, lung, fat pads) reacted much less with the apopto...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(03)00116-x

    authors： Wang XZ,Stepp SE,Brehm MA,Chen HD,Selin LK,Welsh RM

    更新日期：2003-05-01 00:00:00

  • Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors.

    abstract：:The expression of KIR and CD94:NKG2 receptors was determined for more than 100 natural killer (NK) cell clones obtained from two blood donors who differ in their HLA class I and KIR genes. More than 98% of the clones were inhibited by individual autologous class I allotypes, and every clone was inhibited by the combin...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80393-3

    authors： Valiante NM,Uhrberg M,Shilling HG,Lienert-Weidenbach K,Arnett KL,D'Andrea A,Phillips JH,Lanier LL,Parham P

    更新日期：1997-12-01 00:00:00

  • Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.

    abstract：:Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas. A screen based on cytokine expression in the fibrotic lung revealed that the chemokine ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2020.02.007

    authors： Fukushima K,Satoh T,Sugihara F,Sato Y,Okamoto T,Mitsui Y,Yoshio S,Li S,Nojima S,Motooka D,Nakamura S,Kida H,Standley DM,Morii E,Kanto T,Yanagita M,Matsuura Y,Nagasawa T,Kumanogoh A,Akira S

    更新日期：2020-03-17 00:00:00

  • Lnc'ing Id2 to ILC1.

    abstract：:The transcriptional repressor Id2 is constitutively expressed in all innate lymphoid cells (ILCs) and is required for their development. In this issue of Immunity, Mowel et al. (2017) demonstrate that Id2 expression is regulated by a cell type-specific cis-regulatory element in group 1 ILCs that is demarcated by a lon...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2017.08.019

    authors： Sun M,Kee BL

    更新日期：2017-09-19 00:00:00

  • "Nuts and bolts" of disease tolerance.

    abstract：:Disease tolerance describes the ability of an infected host to limit disease severity without negatively impacting the causative pathogen. Bessede et al. (2014) show that the aryl hydrocarbon receptor is an essential component of disease tolerance during bacterial infection in mice. ...

    journal_title：Immunity

    pub_type： 评论,杂志文章

    doi：10.1016/j.immuni.2014.07.011

    authors： Soares MP

    更新日期：2014-08-21 00:00:00

  • Neonatal injection of an ovarian peptide induces autoimmune ovarian disease in female mice: requirement of endogenous neonatal ovaries.

    abstract：:Neonatal female mice injected with the self ZP3 peptide are not tolerant to the peptide; they develop autoimmune ovarian disease (AOD) and autoantibody response 5 weeks later. ZP3 challenge leads to severe AOD and ZP3-specific T cell and antibody responses. In contrast, neonatal tolerance to foreign ZP3 peptide is est...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/s1074-7613(00)80245-9

    authors： Garza KM,Griggs ND,Tung KS

    更新日期：1997-01-01 00:00:00

  • Nucleic Acid Sensors as Therapeutic Targets for Human Disease.

    abstract：:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite prom...

    journal_title：Immunity

    pub_type： 杂志文章,评审

    doi：10.1016/j.immuni.2020.04.004

    authors： McWhirter SM,Jefferies CA

    更新日期：2020-07-14 00:00:00

  • NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING.

    abstract：:Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2014.01.010

    authors： Zhang L,Mo J,Swanson KV,Wen H,Petrucelli A,Gregory SM,Zhang Z,Schneider M,Jiang Y,Fitzgerald KA,Ouyang S,Liu ZJ,Damania B,Shu HB,Duncan JA,Ting JP

    更新日期：2014-03-20 00:00:00

  • Class-Switch Recombination Occurs Infrequently in Germinal Centers.

    abstract：:Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. ...

    journal_title：Immunity

    pub_type： 杂志文章

    doi：10.1016/j.immuni.2019.07.001

    authors： Roco JA,Mesin L,Binder SC,Nefzger C,Gonzalez-Figueroa P,Canete PF,Ellyard J,Shen Q,Robert PA,Cappello J,Vohra H,Zhang Y,Nowosad CR,Schiepers A,Corcoran LM,Toellner KM,Polo JM,Meyer-Hermann M,Victora GD,Vinuesa CG

    更新日期：2019-08-20 00:00:00