Abstract:
:Innate immune sensors that detect nucleic acids are attractive targets for therapeutic intervention because of their diverse roles in many disease processes. In detecting RNA and DNA from either self or non-self, nucleic acid sensors mediate the pathogenesis of many autoimmune and inflammatory conditions. Despite promising pre-clinical data and investigational use in the clinic, relatively few drugs targeting nucleic acid sensors are approved for therapeutic use. Nevertheless, there is growing appreciation for the untapped potential of nucleic acid sensors as therapeutic targets, driven by the need for better therapies for cancer, infectious diseases, and autoimmune disorders. This review highlights the diverse mechanisms by which nucleic acid sensors are activated and exert their biological effects in the context of various disease settings. We discuss current therapeutic strategies utilizing agonists and antagonists targeting nucleic acid sensors to treat infectious disease, cancer, and autoimmune and inflammatory disorders.
journal_name
Immunityjournal_title
Immunityauthors
McWhirter SM,Jefferies CAdoi
10.1016/j.immuni.2020.04.004subject
Has Abstractpub_date
2020-07-14 00:00:00pages
78-97issue
1eissn
1074-7613issn
1097-4180pii
S1074-7613(20)30162-Xjournal_volume
53pub_type
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