Abstract:
:SARS-CoV-2, the causal agent of COVID-19, first emerged in late 2019 in China. It has since infected more than 870,000 individuals and caused more than 43,000 deaths globally. Here, we discuss therapeutic and prophylactic interventions for SARS-CoV-2 with a focus on vaccine development and its challenges. Vaccines are being rapidly developed but will likely come too late to affect the first wave of a potential pandemic. Nevertheless, critical lessons can be learned for the development of vaccines against rapidly emerging viruses. Importantly, SARS-CoV-2 vaccines will be essential to reducing morbidity and mortality if the virus establishes itself in the population.
journal_name
Immunityjournal_title
Immunityauthors
Amanat F,Krammer Fdoi
10.1016/j.immuni.2020.03.007subject
Has Abstractpub_date
2020-04-14 00:00:00pages
583-589issue
4eissn
1074-7613issn
1097-4180pii
S1074-7613(20)30120-5journal_volume
52pub_type
杂志文章,评审相关文献
IMMUNITY文献大全abstract::The death domain kinase RIP and the TNF receptor-associated factor 2 (TRAF2) are essential effectors in TNF signaling. To understand the mechanism by which RIP and TRAF2 regulate TNF-induced activation of the transcription factor NF-kappaB, we investigated their respective roles in TNF-R1-mediated IKK activation using...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80194-6
更新日期:2000-04-01 00:00:00
abstract::T cells that produce IL-17 (T helper 17 cells) are implicated in autoimmune pathogenesis. In this issue of Immunity, Yang et al. (2008) report that the closely related orphan nuclear receptors ROR alpha and ROR gamma t work together to regulate T helper (Th)17 cell differentiation. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2007.12.006
更新日期:2008-01-01 00:00:00
abstract::Lipopolysaccharide binding protein (LBP) has a well-established role in LPS-induced immune responses. Here, we report that LBP also plays an essential role in the innate immune response to Gram-positive pneumococci, specifically to their major inflammatory component, pneumococcal cell wall (PCW). LBP was present in th...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(03)00205-x
更新日期:2003-08-01 00:00:00
abstract::Gallstone formation in adults is a common, yet incompletely understood disease process. In this issue, Muñoz et al. (2019) report a pathogenic link between neutrophil extracellular traps (NETs) and the formation of gallstones. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2019.08.015
更新日期:2019-09-17 00:00:00
abstract::Neutrophils are the first immune cells recruited to sites of inflammation and infection. However, patients with allergic disorders such as atopic dermatitis show a paucity of skin neutrophils and are prone to bacterial skin infections, suggesting that allergic inflammation curtails neutrophil responses. Here we have s...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.06.025
更新日期:2016-07-19 00:00:00
abstract::Notch proteins are cell surface receptors that mediate developmental cell specification events. To explore the function of murine Notch1, an essential portion of the gene was flanked with loxP sites and inactivation induced via interferon-regulated Cre recombinase. Mice with a neonatally induced loss of Notch1 functio...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80054-0
更新日期:1999-05-01 00:00:00
abstract::In this Commentary, McKee et al. highlight the properties of extrinsic vaccine adjuvants that must be considered to achieve the most protective immune response, as occurs naturally with many intrinsic pathogen-derived adjuvants. ...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/j.immuni.2007.11.003
更新日期:2007-11-01 00:00:00
abstract::HS1, the leukocyte-specific homolog of cortactin, regulates F-actin in vitro and is phosphorylated in response to TCR ligation, but its role in lymphocyte activation has not been addressed. We demonstrate that HS1-deficient T cells fail to accumulate F-actin at the immune synapse (IS) and, upon TCR ligation, form acti...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2006.03.022
更新日期:2006-06-01 00:00:00
abstract::Adaptive immune responses by dendritic cells (DCs) are critically controlled by Toll-like receptor (TLR) function. Little is known about modulation of TLR-specific signaling by other pathogen receptors. Here, we have identified a molecular signaling pathway induced by the C-type lectin DC-SIGN that modulates TLR signa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2007.03.012
更新日期:2007-05-01 00:00:00
abstract::The recent characterization of a mutant strain of mice generated five decades ago in a program to study ionizing radiation in mammals (and, ironically, derived from a nonmutagenized control animal) is helping to dissect a now resurgent area of immunology. Despite a vast literature during the 1970s, the study of suppre...
journal_title:Immunity
pub_type: 杂志文章,评审
doi:10.1016/s1074-7613(03)00207-3
更新日期:2003-08-01 00:00:00
abstract::Caspases are intracellular proteases that mediate mammalian cell apoptosis. Caspase-1 (Casp-1) is a unique caspase because it activates the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Shigella flexneri, the etiological agent of bacillary dysentery, induces macrophage apoptosis, which requires Casp-1 an...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80209-5
更新日期:2000-05-01 00:00:00
abstract::Reactive oxygen species (ROS) are generated during T cell activation and serve a signaling function but can also be damaging. In this issue of Immunity, Zhang et al. (2016) show that miR-23a prevents ROS-elicited necrosis by suppressing cyclophilin D (PPIF), a regulator of ROS escape from mitochondria. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2016.02.027
更新日期:2016-03-15 00:00:00
abstract::Lymphoid tissue inducer (LTi) cells are key components of the machinery required for the construction of the lymphoid structures underlying immune responses. In this issue of Immunity, Vonarbourg et. al. (2010) describe how these cells assume several different guises, each associated with different LTi functions. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2010.11.016
更新日期:2010-11-24 00:00:00
abstract::Multipotential naive CD4(+) T cells differentiate into distinct lineages including T helper 1 (Th1), Th2, Th17, and inducible T regulatory (iTreg) cells. The remarkable diversity of CD4(+) T cells begs the question whether the observed changes reflect terminal differentiation with heritable epigenetic modifications or...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2008.12.009
更新日期:2009-01-16 00:00:00
abstract::Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target of the IL-2 signal was identified as the Pax5 transcription factor, BSAP, which recognizes a negative regulatory motif in the J chain promoter. Functional assa...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80263-0
更新日期:1996-10-01 00:00:00
abstract::Mycobacterium tuberculosis infection in humans triggers formation of granulomas, which are tightly organized immune cell aggregates that are the central structure of tuberculosis. Infected and uninfected macrophages interdigitate, assuming an altered, flattened appearance. Although pathologists have described these ch...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2016.09.014
更新日期:2016-10-18 00:00:00
abstract::To investigate the specificity of cytokine signals in hematopoietic differentiation, we generated mice with a targeted mutation of their G-CSF receptor (G-CSFR) such that the cytoplasmic (signaling) domain of the G-CSFR is replaced with the cytoplasmic domain of the erythropoietin receptor. In homozygous mutant mice, ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80090-4
更新日期:1999-08-01 00:00:00
abstract::Glycolysis is linked to the rapid response of memory CD8+ T cells, but the molecular and subcellular structural elements enabling enhanced glucose metabolism in nascent activated memory CD8+ T cells are unknown. We found that rapid activation of protein kinase B (PKB or AKT) by mammalian target of rapamycin complex 2 ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.02.012
更新日期:2018-03-20 00:00:00
abstract::Immunotherapy, especially therapeutic vaccination, has a great deal of potential in the treatment of cancer and certain infectious diseases such as HIV (Allison et al., 2006; Fauci et al., 2008; Feldmann and Steinman, 2005). Numerous vaccine candidates have been tested in patients with a variety of tumor types and chr...
journal_title:Immunity
pub_type: 信件
doi:10.1016/j.immuni.2009.09.007
更新日期:2009-10-16 00:00:00
abstract::In this issue of Immunity, Schweighoffer et al. (2013) report that full BAFF responsiveness in B cells requires the tyrosine kinase Syk and that BAFF may co-opt components of the B cell receptor in transmitting its survival signal. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2013.03.001
更新日期:2013-03-21 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1)-infected corneas can develop a blinding immunoinflammatory condition called herpes stromal keratitis (HSK), which involves the loss of corneal sensitivity due to retraction of sensory nerves and subsequent hyperinnervation with sympathetic nerves. Increased concentrations of the cyt...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.10.013
更新日期:2020-11-17 00:00:00
abstract::Interleukin-1 (IL-1) signaling is important for multiple potentially pathogenic processes in the central nervous system (CNS), but the cell-type-specific roles of IL-1 signaling are unclear. We used a genetic knockin reporter system in mice to track and reciprocally delete or express IL-1 receptor 1 (IL-1R1) in specif...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.12.012
更新日期:2019-02-19 00:00:00
abstract::Metabolic engagement is intrinsic to immune cell function. Prostaglandin E2 (PGE2) has been shown to modulate macrophage activation, yet how PGE2 might affect metabolism is unclear. Here, we show that PGE2 caused mitochondrial membrane potential (Δψm) to dissipate in interleukin-4-activated (M(IL-4)) macrophages. Effe...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2018.10.011
更新日期:2018-12-18 00:00:00
abstract::EBF1 is a pioneer transcription factor involved in B lymphocyte specification. In this issue of Immunity, Wang et al. localize EBF1's pioneering activity to a prion-like domain that mediates recruitment of the nucleosome remodeler Brg1 and FUS-assisted liquid-liquid phase separation. ...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2020.11.013
更新日期:2020-12-15 00:00:00
abstract::Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1). Here we found that the nucleotide-binding, leucine-rich-repeat-containing protein, NLRC3, reduced STING-dependent innate immune...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2014.01.010
更新日期:2014-03-20 00:00:00
abstract::An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed I...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(02)00324-2
更新日期:2002-06-01 00:00:00
abstract::The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebra...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)00017-0
更新日期:2000-08-01 00:00:00
abstract::It is unclear how an effective T cell repertoire is built from a limited array of T cell receptor (TCR) genes. In this issue of Immunity, Stadinski et al. (2011) demonstrate that TCR variable (V) α chains can indirectly affect Vβ-mediated recognition of the major histocompatibility complex (MHC) molecule. ...
journal_title:Immunity
pub_type: 评论,杂志文章
doi:10.1016/j.immuni.2011.11.002
更新日期:2011-11-23 00:00:00
abstract::Mature T cells comprise two mutually exclusive lineages expressing heterodimeric alpha beta or gamma delta antigen receptors. During development, beta, gamma, and delta genes rearrange before alpha, and mature gamma delta cells arise in the thymus prior to alpha beta cells. The mechanism underlying commitment of immat...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/s1074-7613(00)80296-4
更新日期:1996-01-01 00:00:00
abstract::La Crosse virus (LACV), a zoonotic Bunyavirus, is a major cause of pediatric viral encephalitis in the United States. A hallmark of neurological diseases caused by LACV and other encephalitic viruses is the induction of neuronal cell death. Innate immune responses have been implicated in neuronal damage, but no mechan...
journal_title:Immunity
pub_type: 杂志文章
doi:10.1016/j.immuni.2013.02.013
更新日期:2013-04-18 00:00:00